Experimental Animal Decompressions to a Near-Vacuum Environment

Rapid decompression of dogs to near vacuum environment to estimate times of consciousness, collapse, and surviva

Aerodynamic preliminary analysis system 2. Part 1: Theory

An aerodynamic analysis system based on potential theory at subsonic and/or supersonic speeds and impact type finite element solutions at hypersonic conditions is described. Three dimensional configurations having multiple nonplanar surfaces of arbitrary planform and bodies of noncircular contour may be analyzed. Static, rotary, and control longitudinal and lateral directional characteristics may be generated. The analysis was implemented on a time sharing system in conjunction with an input tablet digitizer and an interactive graphics input/output display and editing terminal to maximize its responsiveness to the preliminary analysis problem. The program provides an efficient analysis for systematically performing various aerodynamic configuration tradeoff and evaluation studies

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition

The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile. Inhibition of BSEP is considered a susceptibility factor for drug-induced liver injury that often goes undetected during nonclinical testing. Although in vitro assays exist for screening BSEP inhibition, a reliable and specific method for confirming Bsep inhibition in vivo would be a valuable follow up to a BSEP screening strategy, helping to put a translatable context around in vitro inhibition data, incorporating processes such as metabolism, protein binding, and other exposure properties that are lacking in most in vitro BSEP models. Here, we describe studies in which methods of quantitative intravital microscopy were used to identify dose-dependent effects of two known BSEP/Bsep inhibitors, 2-[4-[4-(butylcarbamoyl)-2-[(2,4-dichlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid (AMG-009) and bosentan, on hepatocellular transport of the fluorescent bile salts cholylglycyl amidofluorescein and cholyl-lysyl-fluorescein in rats. Results of these studies demonstrate that the intravital microscopy approach is capable of detecting Bsep inhibition at drug doses well below those found to increase serum bile acid levels, and also indicate that basolateral efflux transporters play a significant role in preventing cytosolic accumulation of bile acids under conditions of Bsep inhibition in rats. Studies of this kind can both improve our understanding of exposures needed to inhibit Bsep in vivo and provide unique insights into drug effects in ways that can improve our ability interpret animal studies for the prediction of human drug hepatotoxicity

Policy Reform Impact on Food Manufacturing

The impact of agricultural policies and their reform is of major concern when addressing issues of growth, innovation and consolidation in the food manufacturing sector. Growth is one of the forces fueling the globalization of food manufacturing activities. Market- and policy-driven forces present a myriad of opportunities to influence growth and reorientation of patterns at the nexus where food manufacturing links the food system. The productivity and international competitiveness of the food manufacturing sector must be evaluated in the context of governmental incentives, international standards and the emerging supply- and value-chains.total factor productivity growth, intercountry impacts, dairy products, meat products, sugar, Agribusiness, Agricultural and Food Policy,

Long-duration exercise at moderate work loads

Metabolic effects of long duration exercise at moderate work loads including tables of heart rate, rectal temperature, minute volume, water balance, and respiratory quotien

Dynamic techniques for studies of secular variations in position from ranging to satellites

Satellite laser range measurements were applied to the study of latitude variation arising from polar motion, and the solid-earth and ocean tidal distortion of the earth's gravity field. Experiments involving two laser tracking stations were conducted. The relative location of one station with respect to the other was determined by performing simultaneous range measurements to a satellite from two stations several hundred kilometers apart. The application of this technique to the San Andreas Fault Experiment in California is discussed. Future capabilities of spacecraft equipped with laser retroreflectors include: (1) determination of the product of the earth's mass and gravitational constant; (2) measurement of crustal and tectonic motions; (3) determination of the elastic response of the solid-earth tidal forces; (4) measurement of the amplitudes and phase of certain components of the ocean tides; and (5) self-monitoring of the latitude and height variations of the tracking station

Estimates of nonequilibrium ionization phenomena in the inviscid Apollo plasma sheath

Nonequilibrium ionization in asymmetric plasma sheath determined for Apollo spacecraft at superorbital velocity reentr

A Critical Review of Research on Formative Assessments: The Limited Scientific Evidence of the Impact of Formative Assessments in Education

The existence of a plethora of empirical evidence documenting the improvement of educational outcomes through the use of formative assessment is conventional wisdom within education. In reality, a limited body of scientifically based empirical evidence exists to support that formative assessment directly contributes to positive educational outcomes. The use of formative assessments, or other diagnostic efforts within classrooms, provides information that should help facilitate improved pedagogical practices and instructional outcomes. However, a review of the formative assessment literature revealed that there is no agreed upon lexicon with regard to formative assessment and suspect methodological approaches in the efforts to demonstrate positive effects that could be attributed to formative assessments. Thus, the purpose of this article was two-fold. First, the authors set out to clarify the terminology related to formative assessment and its usage. Finally, the article provides a critical analysis of the seminal literature on formative assessment, beginning with Black and Wiliam (1998), and extending through current published materials. Accessed 61,395 times on https://pareonline.net from March 20, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right

Feshbach Resonance Cooling of Trapped Atom Pairs

Spectroscopic studies of few-body systems at ultracold temperatures provide valuable information that often cannot be extracted in a hot environment. Considering a pair of atoms, we propose a cooling mechanism that makes use of a scattering Feshbach resonance. Application of a series of time-dependent magnetic field ramps results in the situation in which either zero, one, or two atoms remain trapped. If two atoms remain in the trap after the field ramps are completed, then they have been cooled. Application of the proposed cooling mechanism to optical traps or lattices is considered.Comment: 5 pages, 3 figures; v.2: major conceptual change

On the Use of Group Theoretical and Graphical Techniques toward the Solution of the General N-body Problem

Group theoretic and graphical techniques are used to derive the N-body wave function for a system of identical bosons with general interactions through first-order in a perturbation approach. This method is based on the maximal symmetry present at lowest order in a perturbation series in inverse spatial dimensions. The symmetric structure at lowest order has a point group isomorphic with the S_N group, the symmetric group of N particles, and the resulting perturbation expansion of the Hamiltonian is order-by-order invariant under the permutations of the S_N group. This invariance under S_N imposes severe symmetry requirements on the tensor blocks needed at each order in the perturbation series. We show here that these blocks can be decomposed into a basis of binary tensors invariant under S_N. This basis is small (25 terms at first order in the wave function), independent of N, and is derived using graphical techniques. This checks the N^6 scaling of these terms at first order by effectively separating the N scaling problem away from the rest of the physics. The transformation of each binary tensor to the final normal coordinate basis requires the derivation of Clebsch-Gordon coefficients of S_N for arbitrary N. This has been accomplished using the group theory of the symmetric group. This achievement results in an analytic solution for the wave function, exact through first order, that scales as N^0, effectively circumventing intensive numerical work. This solution can be systematically improved with further analytic work by going to yet higher orders in the perturbation series.Comment: This paper was submitted to the Journal of Mathematical physics, and is under revie