Planar Laser Induced Fluorescence Mapping of a Carbon Laser Produced Plasma

We present measurements of ion velocity distribution profiles obtained by laser induced fluorescence (LIF) on an explosive laser produced plasma (LPP). The spatio-temporal evolution of the resulting carbon ion velocity distribution was mapped by scanning through the Doppler-shifted absorption wavelengths using a tunable, diode-pumped laser. The acquisition of this data was facilitated by the high repetition rate capability of the ablation laser (1 Hz) which allowed the accumulation of thousand of laser shots in short experimental times. By varying the intensity of the LIF beam, we were able to explore the effects of fluorescence power against laser irradiance in the context of evaluating the saturation versus the non-saturation regime. The small beam size of the LIF beam led to high spatial resolution of the measurement compared to other ion velocity distribution measurement techniques, while the fast-gated operation mode of the camera detector enabled the measurement of the relevant electron transitions

Lightlike infinity in GCA models of Spacetime

This paper discusses a 7 dimensional conformal geometric algebra model for spacetime based on the notion that spacelike and timelike infinities are distinct. I show how naturally of the dimensions represents the lightlike infinity and appears redundant in computations, yet usefull in interpretationComment: 12 page

A holistic multi-methodology for sustainable renovation

A review of the barriers for building renovation has revealed a lack of methodologies, which can promote sustainability objectives and assist various stakeholders during the design stage of building renovation/retrofitting projects. The purpose of this paper is to develop a Holistic Multi-methodology for Sustainable Renovation, which aims to deal with complexity of renovation projects. It provides a framework through which to involve the different stakeholders in the design process to improve group learning and group decision-making, and hence make the building renovation design process more robust and efficient. Therefore, the paper discusses the essence of multifaceted barriers in building renovation regarding cultural changes and technological/physical changes. The outcome is a proposal for a multi-methodology framework, which is developed by introducing, evaluating and mixing methods from Soft Systems Methodologies (SSM) with Multiple Criteria Decision Making (MCDM). The potential of applying the proposed methodology in renovation projects is demonstrated through a case study

Analyzing three-player quantum games in an EPR type setup

We use the formalism of Clifford Geometric Algebra (GA) to develop an analysis of quantum versions of three-player non-cooperative games. The quantum games we explore are played in an Einstein-Podolsky-Rosen (EPR) type setting. In this setting, the players' strategy sets remain identical to the ones in the mixed-strategy version of the classical game that is obtained as a proper subset of the corresponding quantum game. Using GA we investigate the outcome of a realization of the game by players sharing GHZ state, W state, and a mixture of GHZ and W states. As a specific example, we study the game of three-player Prisoners' Dilemma.Comment: 21 pages, 3 figure

Design by taking perspectives: How engineers explore problems

Background: Problem exploration includes identifying, framing, and defining design problems and bounding problem spaces. Intentional and unintentional changes in problem understanding naturally occur as designers explore design problems to create solutions. Through problem exploration, new perspectives on the problem can emerge along with new and diverse ideas for solutions. By considering multiple problem perspectives varying in scope and focus, designers position themselves to increase their understandings of the “real” problem and engage in more diverse idea generation processes leading to an increasing variety of potential solutions. Purpose/Hypothesis: The purpose of this study was to investigate systematic patterns in problem exploration in the early design phases of mechanical engineers. Design/Method: Thirty-five senior undergraduate students and experienced designers with mechanical engineering backgrounds worked individually following a think-aloud protocol. They explored problems and generated solutions for two of four randomly assigned design problems. After generating solutions, participants framed and rewrote problem statements to reflect their perspectives on the design problem their solutions addressed. Thematic analysis and a priori codes guided the identification of problem exploration patterns within and across problems. Results: The set of patterns in engineers\u27 problem exploration that emerged from the analysis documents alternative strategies in exploring problems to arrive at solutions. The results provide evidence that engineering designers, working individually, apply both problem-specific and more general strategies to explore design problems. Conclusions: Our study identified common patterns in the explorations of presented problems by individual engineering designers. The observed patterns, described as Problem Exploration Perspectives, capture alternative approaches to discovering problems and taking multiple problem perspectives during design. Learning about Problem Exploration Perspectives may be helpful in creating alternative perspectives on a design problem, potentially leading to more varied and innovative solutions. This paper concludes with an extended example illustrating the process of applying Problem Exploration Perspectives to move between problem perspectives to generate varied design outcomes

Identifying divergent design thinking through the observable behavior of service design novices

© 2018, Springer Nature B.V. Design thinking holds the key to innovation processes, but is often difficult to detect because of its implicit nature. We undertook a study of novice designers engaged in team-based design exercises in order to explore the correlation between design thinking and designers’ physical (observable) behavior and to identify new, objective, design thinking identification methods. Our study addresses the topic by using data collection method of “think aloud” and data analysis method of “protocol analysis” along with the unconstrained concept generation environment. Collected data from the participants without service design experience were analyzed by open and selective coding. Through the research, we found correlations between physical activity and divergent thinking, and also identified physical behaviors that predict a designer’s transition to divergent thinking. We conclude that there are significant relations between designers’ design thinking and the behavioral features of their body and face. This approach opens possible new ways to undertake design process research and also design capability evaluation

Cost Effectiveness of a CYP2C19 Genotype-Guided Strategy in Patients with Acute Myocardial Infarction:Results from the POPular Genetics Trial

INTRODUCTION: The POPular Genetics trial demonstrated that a CYP2C19 genotype-guided P2Y12 inhibitor strategy reduced bleeding rates compared with standard treatment with ticagrelor or prasugrel without increasing thrombotic event rates after primary percutaneous coronary intervention (PCI). OBJECTIVE: In this analysis, we aimed to evaluate the cost effectiveness of a genotype-guided strategy compared with standard treatment with ticagrelor or prasugrel. METHODS: A 1-year decision tree based on the POPular Genetics trial in combination with a lifelong Markov model was developed to compare costs and quality-adjusted life-years (QALYs) between a genotype-guided and a standard P2Y12 inhibitor strategy in patients with myocardial infarction undergoing primary PCI. The cost-effectiveness analysis was conducted from a Dutch healthcare system perspective. Within-trial survival and utility data were combined with lifetime projections to evaluate lifetime cost effectiveness for a cohort of 1000 patients. Costs and utilities were discounted at 4 and 1.5%, respectively, according to Dutch guidelines for health economic studies. Besides deterministic and probabilistic sensitivity analyses, several scenario analyses were also conducted (different time horizons, different discount rates, equal prices for P2Y12 inhibitors, and equal distribution of thrombotic events between the two strategies). RESULTS: Base-case analysis with a hypothetical cohort of 1000 subjects demonstrated 8.98 QALYs gained and €725,550.69 in cost savings for the genotype-guided strategy (dominant). The deterministic and probabilistic sensitivity analysis confirmed the robustness of the model and the cost-effectiveness results. In scenario analyses, the genotype-guided strategy remained dominant. CONCLUSION: In patients undergoing primary PCI, a CYP2C19 genotype-guided strategy compared with standard treatment with ticagrelor or prasugrel resulted in QALYs gained and cost savings. TRIAL REGISTRATION: Clinicaltrials.gov number: NCT01761786, Netherlands trial register number: NL2872