Proven and Robust Ground Support Systems - GSFC Success and Lessons Learned

Over the past fifteen years, Goddard Space Flight Center has developed several successful science missions in-house: the Wilkinson Microwave Anisotropy Probe (WMAP), the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE), the Earth Observing 1 (EO-1) [1], and the Space Technology 5 (ST-5)[2] missions, several Small Explorers, and several balloon missions. Currently in development are the Solar Dynamics Observatory (SDO) [3] and the Lunar Reconnaissance Orbiter (LRO)[4]. What is not well known is that these missions have been supported during spacecraft and/or instrument integration and test, flight software development, and mission operations by two in house satellite Telemetry and Command (T & C) Systems, the Integrated Test and Operations System (ITOS) and the Advanced Spacecraft Integration and System Test (ASIST). The advantages of an in-house satellite Telemetry and Command system are primarily in the flexibility of management and maintenance - the developers are considered a part of the mission team, get involved early in the development process of the spacecraft and mission operations-control center, and provide on-site, on-call support that goes beyond Help Desk and simple software fixes. On the other hand, care must be taken to ensure that the system remains generic enough for cost effective re-use from one mission to the next. The software is designed such that many features are user-configurable. Where user-configurable options were impractical, features were designed so as to be easy for the development team to modify. Adding support for a new ground message header, for example, is a one-day effort because of the software framework on which that code rests. This paper will discuss the many features of the Goddard satellite Telemetry and Command systems that have contributed to the success of the missions listed above. These features include flexible user interfaces, distributed parallel commanding and telemetry decommutation, a procedure language, the interfaces and tools needed for a high degree of automation, and instantly accessible archives of spacecraft telemetry. It will discuss some of the problems overcome during development, including secure commanding over networks or the Internet, constellation support for the three satellites that comprise the ST-5 mission, and geographically distributed telemetry end users

Prospectus, January 18, 1974

VOTE ENDS IN TIE: SPARKS, WYLIE IN SPECIAL RUNOFF; Both Amendments Passed By Voters; Bob Waldon Wins Vice-Presidency; Sparks Defeats Wylie For StuGo President; SARP Awards Worth $1350; Energy Crisis Discussion Held At Parkland; Gwendolyn Brooks to Appear On Woman\u27s Day; Musical Coming; The Short Circuit; Cruisin\u27 \u2774: The Energy Crisis, Inflation; Prospectus In Perspectice; Letter To Editor; HEW Financial Aids Available; Inclement Weather Policies And Procedures; SIU\u27s Transfer Day To Be Feb. 2; Authorization To Issue Parking Tickets Granted; A Column By And For Women; Growing Up Female ; Nursing School Accredited For Four More Years; \u27Women\u27s Work, Women\u27s Way\u27 To Be Theme Of Jan. 22 Woman\u27s Day; Behind the Books; 50 Hour Documentary The History of Rock & Roll To Be Broadcasted On WLRW; Education: How Practical?; Oregon High School Students Earn Credit In National Guard; Mutt and Mortie; Bio 210 Relates To Earth Day ; Con Men Abound In \u27The Sting\u27; Rules For Safe Winter Driving; MTD Seeks To Serve P/C Better; Fuel Saver Of The State Of Illinois; Bus Survey; Classified Ads; Variety of Tests Available at Parkland Testing Center; Snow Days To Be Made Up In Feb.; Monday\u27s Coach; \u27Super Sunday\u27 Belongs To Miami; Bowling Bulletin Board; Pep Buses; Basketball and Volleyball Are IM Winter Sports; Snowfall Cancels Wrestling Meets; Attention Vets!; Bouncing Bob\u27s Basketball Bonanza; Cobras Even Conference Record At 1-1; Cobra Cager Profiles; Spring Pre-Registration Open January 22 Thru 31; Callboard; Parkland Events; Gardening Class Offered Spring Quarter at P/C; Attention Winter Quarter Graduateshttps://spark.parkland.edu/prospectus_1974/1022/thumbnail.jp

Prospectus, May 13, 1974

CLASS OF \u2774 COMMENCEMENT; Openhouse Set For May 19; 648 Parkland Students Eligible To Participate; Dr. Winters To Speak At Graduation; Parkland Groups Win Awards At Jazz Fest; StuGo President Offers Welcome; Dental Students Capped At Banquet; The Short Circuit; Letters To The Editor; New Stu-Go Officer; President\u27s Report; Crosswords; Parkland College Student Life; Instructional Programs; Admission: Who may Enroll?; Tuition & Fees; Financial Aid; Counseling; Placement; Veterans; Student Life; Summer Session 1974; Academic Calendar 1974-1975; Semester System Fall 1975; In Campus Design, Parkland: Not Just Another School; No Golden Quill This Quarter; Petitioned and Qualified Candidates Spring Quarter 1973-1974; One-Punch Leads To Death Of UI Student; Movie Projector Reported Missing; A Column By and For Women; A Column By and For Men; Self-Help Clinic Set For Women; Vet\u27s Corner; Field Trip Meeting Set; Pig Guards Pot Plot From Police Raid; Blood Drive; Summer Field Course In American Southwest; P/C Student Wins Distinguished Award; Allerton Day Shows Ecological Benefits Of Park; Debate Team Finishes Best Year Ever; Monday\u27s Coach; Thank You; High-Scoring Henrichs Opts For Parkland Cage Team; Parkland Coaches Review Year; Cobras Bat Way Over .500; P/C Players Thrill Audience; Bartow On His Way; Pritchett Not To Be Outdone; On The Way Out; Classified Ads; End-Of-Year Gala Planned By Phys Ed. Dept.; Social, Religious Traditions Expressed In Roots Afrikana; Jones Cites Improvements In Prospectus; Prospectus Staff Positions Open For New School Year; Business Student Wins Award; Krannert Art Schedule; Many Financial Awards Open To Incoming Parkland Students; Parkland Vets Info Center On Wheelshttps://spark.parkland.edu/prospectus_1974/1012/thumbnail.jp

Innovative Solutions for State Medicaid Programs to Leverage Their Data, Build Their Analytic Capacity, and Create Evidence-Based Policy

As states have embraced additional flexibility to change coverage of and payment for Medicaid services, they have also faced heightened expectations for delivering high-value care. Efforts to meet these new expectations have increased the need for rigorous, evidence-based policy, but states may face challenges finding the resources, capacity, and expertise to meet this need. By describing state-university partnerships in more than 20 states, this commentary describes innovative solutions for states that want to leverage their own data, build their analytic capacity, and create evidence-based policy. From an integrated web-based system to improve long-term care to evaluating the impact of permanent supportive housing placements on Medicaid utilization and spending, these state partnerships provide significant support to their state Medicaid programs. In 2017, these partnerships came together to create a distributed research network that supports multi-state analyses. The Medicaid Outcomes Distributed Research Network (MODRN) uses a common data model to examine Medicaid data across states, thereby increasing the analytic rigor of policy evaluations in Medicaid, and contributing to the development of a fully functioning Medicaid innovation laboratory

Prospectus, October 12, 1973

AGNEW RESIGNS VICE-PRESIDENCY; Small Turnout For Election; Prospectus Editors Announced; Walk Attracts Over 600; All Amendments Pass; Prospectus In Perspective: Excellent Bike Path Choice, Letters From Our Readers, New Magazine Coming, At this point in time.....; The Short Circuit; Drama Department Introduces New Lounge Theatre; United Way Campaign Begins; Announces $19,290 Bog Award; Ieardi Headlines Talent Program; Road Rally Club; New Breed of Businessman: Young College Graduate; Student Appointed As Board Member; New Concept For P/C Typing Classes; New Name, Faces For Magazine; Parkland Team To Debate At Bradley Oct. 20; Parkland Instructor Hospitalized at Mercy; PCA Appoints Student Affairs Committee Members; C-U Politics To Be Discussed At Forum; Walk For Mankind; Parkland Announces Bike Rules; Student Senate Reviews Charters, Future Plans; Gayle Wright Chosen To Advise Capstone; Vet\u27s Outreach Aids Readjustment; Prospectus Gains Two Campus Cartoonists; Seminar Planned On \u27Volunteering\u27; P/C Biologists At IACCB Convention; \u27Siege\u27 Shocking, Relevant Film; Faculty Members To Hold Offices; Winter Registration Information; Parkland Student Wins Santa Fe Scholarship; Birthday Wishes; Pre-Registration Benefits All; Target Program To Sponsor Open House; Women Voters Begin Sale Of ERA Bracelet; Ferlinghetti Sues San Francisco Police; Applications Must Be Filed; A Column By And For Women: Born To Be A Woman, The Way It Used To Be, The Lib, I Am Woman; Mutt and Mortie; Fast Freddy\u27s Football Forecast; Fall Intramural; Bowling Bulletin Board; Football Results; Dennis Bailen Wins Fast Freddy; Monday\u27s Coach; Rugby Play Not Football; Harriers Slump To Third, Fourth; Hiser Receives Babe Ruth Award; Graduation; TARGET Sets Sights On Juveniles; Classified Ads; Johnson Calls For Truth, Integrity; Gammon: \u27Everyone Born With Ability\u27; Student President\u27s Report; Lives Changed By Jesus Christ; Cruisin\u27 \u2773; Candidates Learn Voting Procedure; Speleunkers Travel Virgin Paths; Krannert Art Center Schedule; Illini Student Union Movies; Lab Develops Self-Study Habits; Callboard; Race To Fund Town With Doctor; Council Member Proposes Later Bar Hourshttps://spark.parkland.edu/prospectus_1973/1004/thumbnail.jp

Prospectus, April 29, 1974

STUDENTS SEEK GOVERNMENT POSTS; 14 Candidates Run For Major Stu-Go Positions; College Construction Nearing Completion; I.O.C. Sponsors Spring Carnival; Cruisin\u27 \u2774; President\u27s Report; Raines To Speak On Education; Parkland\u27s New School Fight Song; P/C Sponsors Festival Of Foreign Films; A Film For The Times; Doobie\u27s Latest Disappointing; A Column By and For Women; Going Back To Work; Hypertension Screening Tests May 6; Candidates\u27 Platforms; Let\u27s Go To The Bars; Fire Destroys Campus Building; Monday\u27s Coach; IM Department Still Scheduling Sports Events; Give The Girls A Break; Parkland College Baseball (Tentative 1974 Scehdule); Bowling Bulletin Board; Cobra Statistics Reveal Good Odds; Classified Ads; Prepare For Graduation; Graduation Calendar Events; Cobra Tracksters Run To Second At Harper Meet; Crosswords; Parkland Events; Krannert Art Schedule; P/C Jazz Band To Perform In J/C Competition; Committee Announced Special Day; SCI Plans Symposium; Attention E. I. U. Transfer Students; Mime Group Performs Visual Composition; Blood Bank I.D. Cards; Summer Field Course In American Southwesthttps://spark.parkland.edu/prospectus_1974/1014/thumbnail.jp

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better cognition than the canonical group. Groups susceptible to T had more hypometabolism than expected given T and exhibited worse cognitive decline, with imaging and clinical measures concordant with non-AD copathologies. Together, T/NM mismatch reveals distinct imaging signatures with pathobiological and prognostic implications for AD

High-throughput gene discovery in the rat

The rat is an important animal model for human diseases and is widely used in physiology. In this article we present a new strategy for gene discovery based on the production of ESTs from serially subtracted and normalized cDNA libraries, and we describe its application for the development of a comprehensive nonredundant collection of rat ESTs. Our new strategy appears to yield substantially more EST clusters per ESTs sequenced than do previous approaches that did not use serial subtraction. However, multiple rounds of library subtraction resulted in high frequencies of otherwise rare internally primed cDNAs, defining the limits of this powerful approach. To date, we have generated >200,000 3′ ESTs from >100 cDNA libraries representing a wide range of tissues and developmental stages of the laboratory rat. Most importantly, we have contributed to ∼50,000 rat UniGene clusters. We have identified, arrayed, and derived 5′ ESTs from >30,000 unique rat cDNA clones. Complete information, including radiation hybrid mapping data, is also maintained locally at http://genome.uiowa.edu/clcg.html. All of the sequences described in this article have been submitted to the dbEST division of the NCBI

The Alzheimer's Disease Prediction Of Longitudinal Evolution (TADPOLE) Challenge: Results after 1 Year Follow-up

We present the findings of "The Alzheimer's Disease Prediction Of Longitudinal Evolution" (TADPOLE) Challenge, which compared the performance of 92 algorithms from 33 international teams at predicting the future trajectory of 219 individuals at risk of Alzheimer's disease. Challenge participants were required to make a prediction, for each month of a 5-year future time period, of three key outcomes: clinical diagnosis, Alzheimer's Disease Assessment Scale Cognitive Subdomain (ADAS-Cog13), and total volume of the ventricles. No single submission was best at predicting all three outcomes. For clinical diagnosis and ventricle volume prediction, the best algorithms strongly outperform simple baselines in predictive ability. However, for ADAS-Cog13 no single submitted prediction method was significantly better than random guessing. Two ensemble methods based on taking the mean and median over all predictions, obtained top scores on almost all tasks. Better than average performance at diagnosis prediction was generally associated with the additional inclusion of features from cerebrospinal fluid (CSF) samples and diffusion tensor imaging (DTI). On the other hand, better performance at ventricle volume prediction was associated with inclusion of summary statistics, such as patient-specific biomarker trends. The submission system remains open via the website https://tadpole.grand-challenge.org, while code for submissions is being collated by TADPOLE SHARE: https://tadpole-share.github.io/. Our work suggests that current prediction algorithms are accurate for biomarkers related to clinical diagnosis and ventricle volume, opening up the possibility of cohort refinement in clinical trials for Alzheimer's disease