123 research outputs found
Inferring relationships between pairs of individuals from locus heterozygosities
BACKGROUND: The traditional exact method for inferring relationships between individuals from genetic data is not easily applicable in all situations that may be encountered in several fields of applied genetics. This study describes an approach that gives affordable results and is easily applicable; it is based on the probabilities that two individuals share 0, 1 or both alleles at a locus identical by state. RESULTS: We show that these probabilities (z(i)) depend on locus heterozygosity (H), and are scarcely affected by variation of the distribution of allele frequencies. This allows us to obtain empirical curves relating z(i)'s to H for a series of common relationships, so that the likelihood ratio of a pair of relationships between any two individuals, given their genotypes at a locus, is a function of a single parameter, H. Application to large samples of mother-child and full-sib pairs shows that the statistical power of this method to infer the correct relationship is not much lower than the exact method. Analysis of a large database of STR data proves that locus heterozygosity does not vary significantly among Caucasian populations, apart from special cases, so that the likelihood ratio of the more common relationships between pairs of individuals may be obtained by looking at tabulated z(i )values. CONCLUSIONS: A simple method is provided, which may be used by any scientist with the help of a calculator or a spreadsheet to compute the likelihood ratios of common alternative relationships between pairs of individuals
Status of the Cylindical-GEM project for the KLOE-2 Inner Tracker
The status of the R&D on the Cylindrical-GEM (CGEM) detector foreseen as
Inner Tracker for KLOE-2, the upgrade of the KLOE experiment at the DAFNE
phi-factory, will be presented. The R&D includes several activities: i) the
construction and complete characterization of the full-size CGEM prototype,
equipped with 650 microns pitch 1-D longitudinal strips; ii) the study of the
2-D readout with XV patterned strips and operation in magnetic field (up to
1.5T), performed with small planar prototypes in a dedicated test at the H4-SPS
beam facility; iii) the characterization of the single-mask GEM technology for
the realization of large-area GEM foils.Comment: 4 pages, 10 figures, Presented at Vienna Conference on
Instrumentation (Feb 15-20, 2010, Vienna, Austria). Submitted to the
Proceeding
Limit on the production of a new vector boson in , U with the KLOE experiment
The recent interest in a light gauge boson in the framework of an extra U(1)
symmetry motivates searches in the mass range below 1 GeV.
We present a search for such a particle, the dark photon, in , U based on 28 million
events collected at DANE
by the KLOE experiment. The production by initial-state radiation
compensates for a loss of sensitivity of previous KLOE , searches due to the small branching ratios in
the resonance region. We found no evidence for a signal and set a
limit at 90\% CL on the mixing strength between the photon and the dark photon,
, in the U mass range between and ~MeV. Above 700 MeV
this new limit is more stringent than previous ones.Comment: 6 pages, 9 figures, 1 table, submitted to Phys. Lett.
Search for dark Higgsstrahlung in e+ e- -> mu+ mu- and missing energy events with the KLOE experiment
We searched for evidence of a Higgsstrahlung process in a secluded sector,
leading to a final state with a dark photon U and a dark Higgs boson h', with
the KLOE detector at DAFNE. We investigated the case of h' lighter than U, with
U decaying into a muon pair and h' producing a missing energy signature. We
found no evidence of the process and set upper limits to its parameters in the
range 2m_mu<m_U<1000 MeV, m_h'<m_U.Comment: 16 pages, 7 figures, submitted to Physics Letters
Measurement of the transition form factor with the KLOE detector
A measurement of the vector to pseudoscalar conversion decay with the KLOE experiment is presented. A sample of signal
events was selected from a data set of 1.7 fb of collisions at
collected at the DANE collider. These
events were used to obtain the first measurement of the transition form factor
and a new measurement of the branching ratio of the
decay: . The result improves
significantly on previous measurements and is in agreement with theoretical
predictions.Comment: 13 pages, 4 figures; matches published versio
Development of CGEM technology for ultra-light tracking detectors : the KLOE-2 Inner Tracker
KLOE-2 at the -factory DA\Phi NE of INFN Laboratori Nazionali di Frascati (LNF), is the first experiment using the GEM technology with a cylindrical geometry (CGEM), developed at the LNF by the Inner Tracker group and within the RD51 Collaboration. Four layers with 26 41 cm diameters and L = 70 cm, each realized as a Triple-GEM detector, compose this new detector. To produce GEM foils of unprecedented size, the novel single-mask manufacturing procedure has been developed with the TE-MPE-EM CERN group, together with the realization of a novel XV readout pattern. The adopted solutions allowed the total material budget to be kept below 2% of the radiation length . The final assembly of the Inner Tracker has been completed on March 14, 2014. The production procedure will be reported together with the validation test results
Precision measurement of and determination of the contribution to the muon anomaly with the KLOE detector
We have measured the ratio
, with the KLOE detector at DANE for a total integrated
luminosity of 240 pb. From this ratio we obtain the cross section
. From the cross section we determine the
pion form factor and the two-pion contribution to the muon anomaly
for GeV, = . This result confirms the
current discrepancy between the Standard Model calculation and the experimental
measurement of the muon anomaly.Comment: 18 pages, 8 figures, minor text corrections, one table added, version
to appear on Physics Letters
Measurement of {\eta} meson production in {\gamma}{\gamma} interactions and {\Gamma}({\eta}-->{\gamma}{\gamma}) with the KLOE detector
We present a measurement of {\eta} meson production in photon-photon
interactions produced by electron-positron beams colliding with \sqrt{s}=1 GeV.
The measurement is done with the KLOE detector at the \phi-factory DA{\Phi}NE
with an integrated luminosity of 0.24 fb^{-1}. The e^+e^- --> e^+e^-{\eta}
cross section is measured without detecting the outgoing electron and positron,
selecting the decays {\eta}-->{\pi}^+{\pi}^-{\pi}^0 and
{\eta}-->{\pi}^0{\pi}^0{\pi}^0. The most relevant background is due to e^+e^-
--> {\eta}{\gamma} when the monochromatic photon escapes detection. The cross
section for this process is measured as {\sigma}(e^+e^- -->{\eta}{\gamma}) =
(856 \pm 8_{stat} \pm 16_{syst}) pb. The combined result for the e^+e^-
-->e^+e^-{\eta} cross section is {\sigma}(e^+e^- -->e^+e^-{\eta}) = (32.72 \pm
1.27_{stat} \pm 0.70_{syst}) pb. From this we derive the partial width
{\Gamma}({\eta}-->{\gamma}{\gamma}) = (520 \pm 20_{stat} \pm 13_{syst}) eV.
This is in agreement with the world average and is the most precise measurement
to date.Comment: Version accepted by JHE
Precision measurement of the Dalitz plot distribution with the KLOE detector
Using fb of data collected with
the KLOE detector at DANE, the Dalitz plot distribution for the decay is studied with the world's largest sample of events. The Dalitz plot density is parametrized as a polynomial
expansion up to cubic terms in the normalized dimensionless variables and
. The experiment is sensitive to all charge conjugation conserving terms of
the expansion, including a term. The statistical uncertainty of all
parameters is improved by a factor two with respect to earlier measurements.Comment: 11 pages, 9 figures, supplement: an ascii tabl
A new limit on the CP violating decay KS -> 3pi0 with the KLOE experiment
We have carried out a new direct search for the CP violating decay KS -> 3pi0
with 1.7 fb^-1 of e+e- collisions collected by the KLOE detector at the
phi-factory DAFNE. We have searched for this decay in a sample of about 5.9 x
10^8 KS KL events tagging the KS by means of the KL interaction in the
calorimeter and requiring six prompt photons. With respect to our previous
search, the analysis has been improved by increasing of a factor four the
tagged sample and by a more effective background rejection of fake KS tags and
spurious clusters. We find no candidates in data and simulated background
samples, while we expect 0.12 standard model events. Normalizing to the number
of KS -> 2pi0 events in the same sample, we set the upper limit on BR(KS ->
3pi0 < 2.6 x 10^-8 at 90% C.L., five times lower than the previous limit. We
also set the upper limit on the eta_000 parameter, |eta_000 | < 0.0088 at 90%
C.L., improving by a factor two the latest direct measurement.Comment: Accepted for publication in Physics Letters B (15 pages, 13 figures
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