GODAE systems in operation

During the last 15 years, operational oceanography systems have emerged in several countries around the world. This emergence has been largely fostered by the GODAE experiment, during which each nation engaged in this activity have organised partnership and constructive competition. This trans-national coordination was very beneficial for the development of operational oceanography, leading to economies of scales and more targeted actions. Today, several systems provide routine real-time ocean analysis and forecast and/or reanalysis products. They are all based on (i) state-of-the-art primitive equation baroclinic Ocean General Circulation Model (OGCM) configurations, either global or regional (basin-scale), with resolutions that range from coarse to eddy resolving and (ii) data assimilation techniques whose complexity ranges from simple analysis correction to advanced 4D variational schemes. They assimilate altimeter sea level anomalies, remotely sensed SST such as GHRSST products and in situ profiles of T and S, including ARGO. Some systems have implemented downscaling capacities in specific regions of interest including shelf/coastal seas. Some also have implemented coupling with the atmosphere and/or the prognostic sea ice in polar regions. They are the GODAE system in operation. They are reviewed in this paper. The GODAE system discussed here include: (1) BLUElink OceanMAPS, (2) C-NOOFS, , (3) ECCO, (4) FOAM, (5) HYCOM/NCODA, (6) MERCATOR, (7) MFS, (8) MOVE/MRI.COM, (9) NLOM/NCOM, (10) NMEFC, (11) RTOFS and (12) TOPAZ.SubmittedNice, France3.11. Oceanografia Operativaope

GODAE systems in operation

During the last 15 years, operational oceanography systems have been developed in several countries around the world. These developments have been fostered primarily by the Global Ocean Data Assimilation Experiment (GODAE), which coordinated these activities, encouraged partnerships, and facilitated constructive competition. This multinational coordination has been very beneficial for the development of operational oceanography. Today, several systems provide routine, real-time ocean analysis, forecast, and reanalysis products. These systems are based on (1) state-of-the-art Ocean General Circulation Model (OGCM) configurations, either global or regional (basin-scale), with resolutions that range from coarse to eddy-resolving, and (2) data assimilation techniques ranging from analysis correction to advanced three- or four-dimensional variational schemes. These systems assimilate altimeter sea level anomalies, sea surface temperature data, and in situ profiles of temperature and salinity, including Argo data. Some systems have implemented downscaling capacities, which consist of embedding higher-resolution local systems in global and basin-scale models (through open boundary exchange of data), especially in coastal regions, where small scale-phenomena are important, and also increasing the spatial resolution for these regional/coastal systems to be able to resolve smaller scales (so-called downscaling). Others have implemented coupling with the atmosphere and/or sea ice. This paper provides a short review of these operational GODAE systems.Published76-914.6. Oceanografia operativa per la valutazione dei rischi in aree marineN/A or not JCRope

GODAE systems in operation

During the last 15 years, operational oceanography systems have emerged in several countries around the world. This emergence has been largely fostered by the GODAE experiment, during which each nation engaged in this activity have organised partnership and constructive competition. This trans-national coordination was very beneficial for the development of operational oceanography, leading to economies of scales and more targeted actions. Today, several systems provide routine real-time ocean analysis and forecast and/or reanalysis products. They are all based on (i) state-of-the-art primitive equation baroclinic Ocean General Circulation Model (OGCM) configurations, either global or regional (basin-scale), with resolutions that range from coarse to eddy resolving and (ii) data assimilation techniques whose complexity ranges from simple analysis correction to advanced 4D variational schemes. They assimilate altimeter sea level anomalies, remotely sensed SST such as GHRSST products and in situ profiles of T and S, including ARGO. Some systems have implemented downscaling capacities in specific regions of interest including shelf/coastal seas. Some also have implemented coupling with the atmosphere and/or the prognostic sea ice in polar regions. They are the GODAE system in operation. They are reviewed in this paper. The GODAE system discussed here include: (1) BLUElink OceanMAPS, (2) C-NOOFS, , (3) ECCO, (4) FOAM, (5) HYCOM/NCODA, (6) MERCATOR, (7) MFS, (8) MOVE/MRI.COM, (9) NLOM/NCOM, (10) NMEFC, (11) RTOFS and (12) TOPAZ

GODAE systems in operation

During the last 15 years, operational oceanography systems have been developed in several countries around the world. These developments have been fostered primarily by the Global Ocean Data Assimilation Experiment (GODAE), which coordinated these activities, encouraged partnerships, and facilitated constructive competition. This multinational coordination has been very beneficial for the development of operational oceanography. Today, several systems provide routine, real-time ocean analysis, forecast, and reanalysis products. These systems are based on (1) state-of-the-art Ocean General Circulation Model (OGCM) configurations, either global or regional (basin-scale), with resolutions that range from coarse to eddy-resolving, and (2) data assimilation techniques ranging from analysis correction to advanced three- or four-dimensional variational schemes. These systems assimilate altimeter sea level anomalies, sea surface temperature data, and in situ profiles of temperature and salinity, including Argo data. Some systems have implemented downscaling capacities, which consist of embedding higher-resolution local systems in global and basin-scale models (through open boundary exchange of data), especially in coastal regions, where small scale-phenomena are important, and also increasing the spatial resolution for these regional/coastal systems to be able to resolve smaller scales (so-called downscaling). Others have implemented coupling with the atmosphere and/or sea ice. This paper provides a short review of these operational GODAE systems

The role of valuation and bargaining in optimising transboundary watercourse treaty regimes

In the face of water scarcity, growing water demands, population increase, ecosystem degradation, climate change, and so on transboundary watercourse states inevitably have to make difficult decisions on how finite quantities of water are distributed. Such waters, and their associated ecosystem services, offer multiple benefits. Valuation and bargaining can play a key role in the sharing of these ecosystems services and their associated benefits across sovereign borders. Ecosystem services in transboundary watercourses essentially constitute a portfolio of assets. Whilst challenging, their commodification, which creates property rights, supports trading. Such trading offers a means by which to resolve conflicts over competing uses and allows states to optimise their ‘portfolios’. However, despite this potential, adoption of appropriate treaty frameworks that might facilitate a market-based approach to the discovery and allocation of water-related ecosystem services at the transboundary level remains both a challenge, and a topic worthy of further study. Drawing upon concepts in law and economics, this paper therefore seeks to advance the study of how treaty frameworks might be developed in a way that supports such a market-based approach to ecosystem services and transboundary waters

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Congenital Heart Disease (CHD) affects approximately 7-9 children per 1000 live births. Numerous genetic studies have established a role for rare genomic variants at the copy number variation (CNV) and single nucleotide variant level. In particular, the role of de novo mutations (DNM) has been highlighted in syndromic and non-syndromic CHD. To identify novel haploinsufficient CHD disease genes we performed an integrative analysis of CNVs and DNMs identified in probands with CHD including cases with sporadic thoracic aortic aneurysm (TAA). We assembled CNV data from 7,958 cases and 14,082 controls and performed a gene-wise analysis of the burden of rare genomic deletions in cases versus controls. In addition, we performed mutation rate testing for DNMs identified in 2,489 parent-offspring trios. Our combined analysis revealed 21 genes which were significantly affected by rare genomic deletions and/or constrained non-synonymous de novo mutations in probands. Fourteen of these genes have previously been associated with CHD while the remaining genes (FEZ1, MYO16, ARID1B, NALCN, WAC, KDM5B and WHSC1) have only been associated in singletons and small cases series, or show new associations with CHD. In addition, a systems level analysis revealed shared contribution of CNV deletions and DNMs in CHD probands, affecting protein-protein interaction networks involved in Notch signaling pathway, heart morphogenesis, DNA repair and cilia/centrosome function. Taken together, this approach highlights the importance of re-analyzing existing datasets to strengthen disease association and identify novel disease genes

Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot

Purpose Rare genetic variants in KDR, encoding the vascular endothelial growth factor receptor 2 (VEGFR2), have been reported in patients with tetralogy of Fallot (TOF). However, their role in disease causality and pathogenesis remains unclear. Methods We conducted exome sequencing in a familial case of TOF and large-scale genetic studies, including burden testing, in >1,500 patients with TOF. We studied gene-targeted mice and conducted cell-based assays to explore the role of KDR genetic variation in the etiology of TOF. Results Exome sequencing in a family with two siblings affected by TOF revealed biallelic missense variants in KDR. Studies in knock-in mice and in HEK 293T cells identified embryonic lethality for one variant when occurring in the homozygous state, and a significantly reduced VEGFR2 phosphorylation for both variants. Rare variant burden analysis conducted in a set of 1,569 patients of European descent with TOF identified a 46-fold enrichment of protein-truncating variants (PTVs) in TOF cases compared to controls (P = 7 x 10(-11)). Conclusion Rare KDR variants, in particular PTVs, strongly associate with TOF, likely in the setting of different inheritance patterns. Supported by genetic and in vivo and in vitro functional analysis, we propose loss-of-function of VEGFR2 as one of the mechanisms involved in the pathogenesis of TOF.Developmen