Microstructure and impact toughness of high-strength low-alloy steel after tempforming

The effects of temperature and degree of tempforming deformation on the microstructure and impact toughness of high-strength low-alloy 25KhGMT steel have been considered. Tempforming forms a lamellar microstructure composed of grains and subgrains that are strongly elongated along the rolling directio

Клеточно-молекулярные механизмы развития остеопороза: современные концепции и будущее направление терапии

The article presents review of literature dedicated to the contemporary view on the cellular-molecular mechanisms of the bone remodeling and pathogenesis of the osteoporosis. The discovery of the cytokine RANKL-RANK-OPG system and significant role of the cathepsin K in process bone remodeling has made progress in understanding the mechanisms development disease and possible to development drugs of the new generation – denosumab, a fully human RANKL monoclonal antibody and inhibitor cathepsin K odanacatib that inhibits of the bone resorption.В обзоре литературы представлены современные взгляды на клеточно-молекулярные механизмы развития ремоделирования кости и патогенез остеопороза. Открытие цитокиновой системы RANKL-RANK-OPG и значительной роли катепсина К в процессе ремоделирования костной ткани способствовало значительному прогрессу в понимание механизмов развития остеопороза и позволило разработать препараты нового поколения – деносумаб, полностью человеческое моноклональное антитело к RANKL (receptor activator nucleus factor kappa B ligand), и ингибитор катепсина К оданакатиб, угнетающие процесс резорбции костной ткани

Effect of thermomechanical treatment on the microstructure and mechanical properties of a low-carbon low-alloy steel

The effect of thermomechanical treatment on the microstructure, tensile strength and impact toughness of low-carbon low-alloy steel is considered. The developed microstructure is characterized by grain elongation along the rolling direction. Both the yield strength and the ultimate tensile strength increase with a decrease in test temperature. The ultimate strength at room temperature is 797 MPa, and at 77 K the ultimate strength increases to 1198 MPa. The steel samples subjected to tempforming exhibit impact toughness of KCV = 410 J/cm2 at room temperatur

Методика повышения организационной эффективности предприятия

Purpose: of the study is to present and study the results of the implementation of the methodology for improving organizational efficiency, which was tested at an industrial enterprise in the Sverdlovsk region.Methods: traditional general scientific methods were used in the study: analysis, synthesis, generalization, literature review, case study analysis on the materials of an industrial enterprise, in the practice of which the use of methods for improving organizational efficiency was introduced.Results: improving the organizational efficiency and labor productivity of industrial enterprises is an important direction in the development of the economy and production since these companies make a significant contribution to the welfare of the country and the quality of life of the population. Some domestic companies are developing and implementing tools to improve organizational efficiency, and it is important to understand what results the business achieves after implementing such changes. Such a tool can be the author's methodology for improving organizational efficiency. Approbation of the methodology showed that as a result of its use at an industrial enterprise for a production volume of 500 thousand tons, an organizational effect was obtained in the form of the release of 718 staff positions at the initial values of 5 463 staff positions, which amounted to 13.14%. According to calculations, within 12 months from the start of the implementation of the initiatives, 132.6 million rubles, or 30.9% of the target economic effect, will be received. Additional investments of 94 million rubles can bring 13% of the identified potential, or 93 staff positions with the effect of 56.9 million rubles.Conclusions and Relevance: the approbation of the methodology for improving organizational efficiency showed that it can be implemented at industrial enterprises of the country, taking into account adaptation to different industries and the specifics of the company's activities. The application of the methodology can provide companies with an increase in the economic effect by 10-15%. However, for full implementation and scaling, comprehensive work should be carried out to train personnel, optimize processes, and introduce methods to improve organizational efficiency in the daily practice of employees.Цель статьи - представить результаты внедрения методики повышения организационной эффективности, апробация которой была проведена на одном из промышленных предприятий Свердловской области.Методы. В работе были использованы традиционные общенаучные методы: анализ, синтез, обобщение, обзор литературы, анализ случая (case-study) на материалах промышленного предприятия, в практику которого было внедрено использование методики повышения организационной эффективности.Результаты работы. Повышение организационной эффективности и производительности труда промышленных предприятий является важным направлением развития экономики и производства, поскольку эти компании вносят значительный вклад в благосостояние страны и качество жизни населения. Некоторые отечественные компании разрабатывают и внедряют инструменты повышения организационной эффективности, и важно понимать, каких результатов добивается бизнес после реализации подобных изменений. Таким инструментом может быть авторская методика повышения организационной эффективности. В результате ее использования на промышленном предприятии на объем производства в 500 тыс. тонн был получен организационный эффект в виде высвобождения 718-ти штатных единиц при изначальных значениях в 5463 штатные единицы, что составило 13,14%. По расчетам, в течение 12-ти месяцев с начала реализации инициатив будет получено 132,6 млн руб., или 30,9% целевого экономического эффекта. Дополнительные инвестиции в 94 млн руб. способны принести 13% от выявленного потенциала, или 93 штатные единицы с эффектом 56,9 млн руб.Выводы. Апробация методики повышения организационной эффективности показала, что она может быть внедрена на промышленных предприятиях страны, с учетом адаптации под разные отрасли и специфику деятельности компании. Применение методики может обеспечить для компаний прирост экономического эффекта на 10-15%. Однако для полноценного внедрения и масштабирования должна быть проведена комплексная работа по обучению персонала, оптимизации процессов, внедрению методов повышения организационной эффективности в каждодневную практику работников

Microstructure and strengthening mechanisms in an HSLA steel subjected to tempforming

An effect of tempforming on the microstructure, the carbide precipitation, and the strengthening mechanisms of high strength lowalloyed steel has been analyze

Impact toughness of an S700MC-type steel: Tempforming vs ausforming

The effect of different thermomechanical treatments, i.e., ausforming and tempforming, on the microstructure and mechanical properties including impact fracture behavior of high-strength low-carbon S700MC-type steel was investigate

SURFACE HARDENING OF AUTOMOBILES AND TRACTORS PARTS BY METHOD OF LOW-TEMPERATURE CARBONITRIDING IN POWDER MEDIUM

Performed is strengthening of the surface layer of steel method of low-temperature carbonitriding in macrodispersed carbo - and nitrogen-bearing powder mixture. Chosen and justified the optimal technological parameters of process developed chemical-thermal processing. The diffusion coefficient of nitrogen alloyed steel 40X for the proposed treatment

Effects of combination antihypertensive therapy on intracardiac hemodynamics and blood vessels in patients with coronary heart disease, post-infarction cardiosclerosis and arterial hypertension

The aim of the work is to assess the effectiveness of prescribing a fixed-dose combination of amlodipine with the ACE inhibitor lisinopril or with the angiotensin 2 receptor blocker valsartan in patients with coronary artery disease, acute coronary syndrome with hypertensive disease regarding the impact on the structural and functional parameters of the heart and extracranial branches of the brachiocephalic arteries. Materials and methods. General clinical examination of 108 patients with postinfarction cardiosclerosis and hypertension was done within 12 months. The patients were allocated to two groups. Patients in the first group (n = 50) were assigned a fixed-dose combination of lisinopril and amlodipine (20 mg and 5 mg, respectively), and patients in the second group (n = 58) received a fixed-dose combination of valsartan with amlodipine (160 mg and 5 mg, respectively). The patients were monitored for 12 months, including general clinical examinations, measurements of office blood pressure (BP), 24-hour BP monitoring, echo-dopplerographic examination of the heart and brachiocephalic arteries, determination of the composite endpoint. Statistical analysis of the obtained data was performed using Microsoft Excel, IBM SPSS Statistics v.23. Results. A significant difference in echocardiographic data has been proved (p 0.05) have been found in the first group. When analyzing the indicators of diastolic function in the second group, a highly significant (p < 0.05) decrease in E/A, E/E’, IO of the LA has been revealed; data analysis on the morphofunctional state indicators of the extracranial arteries has shown a CIM reduction and a decrease in PSV and RI. Conclusions. Prescriptions of the fixed-dose combination of amlodipine with the ACE inhibitor lisinopril was more effective in terms of the LV measurements (p < 0.05) and LV diastolic function as evidenced by decreased E/A, E/E’ and IO of the LA (p < 0.05) as compared to the data in the group of amlodipine with the angiotensin 2 receptor blocker valsartan. Both fixed-dose combinations were effective in reducing the CIM thickness, decreasing PSV and RI when analyzing the morphofunctional state findings of the extracranial arteries

Effect of friction stir welding and tempering on the microstructure and strength of a tempformed low-alloy steel

The microstructure developed in a low-alloy steel during friction stir welding and post-weld tempering was studied. The quenched steel samples were subjected to tempering at 650 ◦C for 1 h, followed by warm rolling to a total strain of 1.5 at the same temperatur

National cultural characteristics of the Khanty’s communicative behavior in stimulating speech acts

The scientific article for the first time presents a study of the ways of expressing motives on the material of the Khanty language. These methods are comprehensively analyzed in specific communicative situations used by the speaker and addressed to the listener. The imperative paradigm in speech constructs includes word forms of the verbal lexeme, expressing an imperative meaning addressed to the listener. As a result of linguistic analysis of such speech acts, it is revealed that the speaker’s will regarding the execution of the called action is expressed regardless of who performs the action: the listener, the speaker, the person not participating in the speech act, or any combination of the listed persons. The main (nuclear) way of expressing an impulse is an imperative construct