Design and Synthesis of Thiamine Analogs as Anti-Cancer Therapeutics

Cancer is one of the leading causes of death. There have been many investigations into therapeutic ways to prevent and reverse cancerous growth. We report a new approach in this thesis, which is to investigate the functions of Vitamin B1 (thiamine) in cancerous cells and their regulation. A number of thiamine analogs were synthesized to carry out the structure-activity relationship (SAR) studies with two transporters THTR1 and THTR2. Initial results show that the modifications of thiazole reduced the uptake of thiamine

Synthesis of Small Molecules for Diagnostics and Therapeutics of Influenza Virus

Influenza infection remains a constant threat to human health and results in huge financial loss annually. Rapid and accurate detection of influenza can aid health officials to monitor influenza activity and take measurements when necessary. In addition, influenza detection in a timely manner can help doctors make diagnosis and provide effective treatment. Additionally, novel inhibitors of influenza virus are in high demand because circulating strains have started to develop resistance to currently available anti-viral drugs. Influenza virus has two surface glycoproteins: hemagglutinin (HA) and neuraminidase (NA), which play important roles in the influenza infection. The binding of HA to sialic acid-containing carbohydrates on cell surface initiates virus internalization, while cleavage of terminal sialic acid by NA facilitates viral particle release. In this dissertation, we focus on the development of a glycan microarray that is comprised of a panel of NA resistant sialosides, and demonstrate the application of the microarray to capture influenza virus at ambient temperature without the addition of NA inhibitors. We also describe a novel electrochemical assay for the detection of influenza virus. In addition, we have developed a new class of bivalent NA inhibitors that show promising inhibitory activities against influenza viruses

Emerging Technologies for 6G Non-Terrestrial-Networks: From Academia to Industrial Applications

Terrestrial networks form the fundamental infrastructure of modern communication systems, serving more than 4 billion users globally. However, terrestrial networks are facing a wide range of challenges, from coverage and reliability to interference and congestion. As the demands of the 6G era are expected to be much higher, it is crucial to address these challenges to ensure a robust and efficient communication infrastructure for the future. To address these problems, Non-terrestrial Network (NTN) has emerged to be a promising solution. NTNs are communication networks that leverage airborne (e.g., unmanned aerial vehicles) and spaceborne vehicles (e.g., satellites) to facilitate ultra-reliable communications and connectivity with high data rates and low latency over expansive regions. This article aims to provide a comprehensive survey on the utilization of network slicing, Artificial Intelligence/Machine Learning (AI/ML), and Open Radio Access Network (ORAN) to address diverse challenges of NTNs from the perspectives of both academia and industry. Particularly, we first provide an in-depth tutorial on NTN and the key enabling technologies including network slicing, AI/ML, and ORAN. Then, we provide a comprehensive survey on how network slicing and AI/ML have been leveraged to overcome the challenges that NTNs are facing. Moreover, we present how ORAN can be utilized for NTNs. Finally, we highlight important challenges, open issues, and future research directions of NTN in the 6G era

Carbon dioxide reforming of methane over modified iron-cobalt alumina catalyst : Role of promoter

Cobalt-based catalysts are widely employed in methane dry reforming but tend to deactivate quickly due to coke deposits and metal sintering. To enhance the performance, iron, a cost-effective promoter, is added, improving cobalt's metal dispersibility, reducibility, and basicity on the support. This addition accelerates carbon gasification, effectively inhibiting coke deposition. Methods: A series of iron-doped cobalt alumina MFe-5Co/Al2O3 (M= 0, 0.4, 0.8, 1, 2 wt.%) were prepared via simple incipient-wetness impregnation. The catalysts were thoroughly characterized via modern techniques including BET, XRD, H2-TPR, CO2-TPD. Significant findings: The addition of iron had a minimal impact on the properties of γ-Al2O3, but it significantly affected the dispersibility of cobalt. At an optimal dosage of 0.8 wt.%, there was a notable decrease of 29.44% in Co3O4 particle size. However, excessive iron loading induced agglomeration of Co3O4, which was reversible. The presence of iron also resulted in a decrease in the reduction temperature of Co3O4. The material's basicity was primarily influenced by the loading of iron, reaching its highest value of 705.7 μmol CO2 g−1 in the 2Fe-5Co/Al2O3. The correlation between catalytic activity and the physicochemical properties of the material was established. The 0.8Fe-5Co/Al2O3 sample exhibited excellent performance due to the favorable dispersibility of cobalt, its reducibility, and its affordable basicity

A hidden HIV epidemic among women in Vietnam

<p>Abstract</p> <p>Background</p> <p>The HIV epidemic in Vietnam is still concentrated among high risk populations, including IDU and FSW. The response of the government has focused on the recognized high risk populations, mainly young male drug users. This concentration on one high risk population may leave other populations under-protected or unprepared for the risk and the consequences of HIV infection. In particular, attention to women's risks of exposure and needs for care may not receive sufficient attention as long as the perception persists that the epidemic is predominantly among young males. Without more knowledge of the epidemic among women, policy makers and planners cannot ensure that programs will also serve women's needs.</p> <p>Methods</p> <p>More than 300 documents appearing in the period 1990 to 2005 were gathered and reviewed to build an understanding of HIV infection and related risk behaviors among women and of the changes over time that may suggest needed policy changes.</p> <p>Results</p> <p>It appears that the risk of HIV transmission among women in Vietnam has been underestimated; the reported data may represent as little as 16% of the real number. Although modeling predicted that there would be 98,500 cases of HIV-infected women in 2005, only 15,633 were accounted for in reports from the health system. That could mean that in 2005, up to 83,000 women infected with HIV have not been detected by the health care system, for a number of possible reasons. For both detection and prevention, these women can be divided into sub-groups with different risk characteristics. They can be infected by sharing needles and syringes with IDU partners, or by having unsafe sex with clients, husbands or lovers. However, most new infections among women can be traced to sexual relations with young male injecting drug users engaged in extramarital sex. Each of these groups may need different interventions to increase the detection rate and thus ensure that the women receive the care they need.</p> <p>Conclusion</p> <p>Women in Vietnam are increasingly at risk of HIV transmission but that risk is under-reported and under-recognized. The reasons are that women are not getting tested, are not aware of risks, do not protect themselves and are not being protected by men. Based on this information, policy-makers and planners can develop better prevention and care programs that not only address women's needs but also reduce further spread of the infection among the general population.</p

Difficulties in Diagnosis and Operation Associated With Lumbar Intradural Disc Herniation: A Case Report: Lumbar intradural disc herniation

Intradural disk herniation (IDH) represents an uncommon instance of disk degeneration. The surgical treatment of IDH,preoperative, and intraoperative diagnosis are difficult. The present case report highlights the difficult parts of diagnosis and surgery.A 44-year-old man presented with lower back pain radiating to his right leg. A disk protruding into the ventral dural sac andexhibiting the hawk-beak sign was discovered by MRI. The dorsal side was exposed and incised during L3/4 laminectomy, apuncture on the ventral side was detected, and subsequently, three fragments extending into the dura sac were discovered. Thedefect was corrected and completed internal fixing was done. Pathology identified it as nucleus pulposus tissue. At one-monthfollow-up, he was able to walk normally. An incredibly uncommon form of disc degeneration is lumbar IDH. MRI can assist inthe diagnosis, however, surgical investigation and pathology are necessary for an accurate diagnosis