2,016 research outputs found
Thermodynamic analysis of black hole solutions in gravitating nonlinear electrodynamics
We perform a general study of the thermodynamic properties of static
electrically charged black hole solutions of nonlinear electrodynamics
minimally coupled to gravitation in three space dimensions. The Lagrangian
densities governing the dynamics of these models in flat space are defined as
arbitrary functions of the gauge field invariants, constrained by some
requirements for physical admissibility. The exhaustive classification of these
theories in flat space, in terms of the behaviour of the Lagrangian densities
in vacuum and on the boundary of their domain of definition, defines twelve
families of admissible models. When these models are coupled to gravity, the
flat space classification leads to a complete characterization of the
associated sets of gravitating electrostatic spherically symmetric solutions by
their central and asymptotic behaviours. We focus on nine of these families,
which support asymptotically Schwarzschild-like black hole configurations, for
which the thermodynamic analysis is possible and pertinent. In this way, the
thermodynamic laws are extended to the sets of black hole solutions of these
families, for which the generic behaviours of the relevant state variables are
classified and thoroughly analyzed in terms of the aforementioned boundary
properties of the Lagrangians. Moreover, we find universal scaling laws (which
hold and are the same for all the black hole solutions of models belonging to
any of the nine families) running the thermodynamic variables with the electric
charge and the horizon radius. These scale transformations form a one-parameter
multiplicative group, leading to universal "renormalization group"-like
first-order differential equations. The beams of characteristics of these
equations generate the full set of black hole states associated to any of these
gravitating nonlinear electrodynamics...Comment: 51 single column pages, 19 postscript figures, 2 tables, GRG tex
style; minor corrections added; final version appearing in General Relativity
and Gravitatio
The Surgical Infection Society revised guidelines on the management of intra-abdominal infection
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and 2010. At the time the most recent guideline was released, the plan was to update the guideline every five years to ensure the timeliness and appropriateness of the recommendations.
Methods: Based on the previous guidelines, the task force outlined a number of topics related to the treatment of patients with IAI and then developed key questions on these various topics. All questions were approached using general and specific literature searches, focusing on articles and other information published since 2008. These publications and additional materials published before 2008 were reviewed by the task force as a whole or by individual subgroups as to relevance to individual questions. Recommendations were developed by a process of iterative consensus, with all task force members voting to accept or reject each recommendation. Grading was based on the GRADE (Grades of Recommendation Assessment, Development, and Evaluation) system; the quality of the evidence was graded as high, moderate, or weak, and the strength of the recommendation was graded as strong or weak. Review of the document was performed by members of the SIS who were not on the task force. After responses were made to all critiques, the document was approved as an official guideline of the SIS by the Executive Council.
Results: This guideline summarizes the current recommendations developed by the task force on the treatment of patients who have IAI. Evidence-based recommendations have been made regarding risk assessment in individual patients; source control; the timing, selection, and duration of antimicrobial therapy; and suggested approaches to patients who fail initial therapy. Additional recommendations related to the treatment of pediatric patients with IAI have been included.
Summary: The current recommendations of the SIS regarding the treatment of patients with IAI are provided in this guideline
Higher Spin Gauge Theory and Holography: The Three-Point Functions
In this paper we calculate the tree level three-point functions of Vasiliev's
higher spin gauge theory in AdS4 and find agreement with the correlators of the
free field theory of N massless scalars in three dimensions in the O(N) singlet
sector. This provides substantial evidence that Vasiliev theory is dual to the
free field theory, thus verifying a conjecture of Klebanov and Polyakov. We
also find agreement with the critical O(N) vector model, when the bulk scalar
field is subject to the alternative boundary condition such that its dual
operator has classical dimension 2.Comment: 90 pages, 5 figures; v4, minor changes in the introductio
Comparison of Argentinean Saint Louis Encephalitis Virus Non-Epidemic and Epidemic Strain Infections in an Avian Model
St. Louis encephalitis virus (SLEV, Flavivirus, Flaviviridae) is an emerging mosquito-borne pathogen in South America, with human SLEV encephalitis cases reported in Argentina and Brazil. Genotype III strains of SLEV were isolated from Culex quinquefasciatus mosquitoes in Cordoba, Argentina in 2005, during the largest SLEV outbreak ever reported in South America. The present study tested the hypothesis that the recent, epidemic SLEV strain exhibits greater virulence in birds as compared with a non-epidemic genotype III strain isolated from mosquitoes in Santa Fe Province 27 years earlier. The observed differences in infection parameters between adult House sparrows (Passer domesticus) that were needle-inoculated with either the epidemic or historic SLEV strain were not statistically significant. However, only the House sparrows that were infected with the epidemic strain achieved infectious-level viremia titers sufficient to infect Cx. spp. mosquitoes vectors. Furthermore, the vertebrate reservoir competence index values indicated an approximately 3-fold increase in amplification potential of House sparrows infected with the epidemic strain when pre-existing flavivirus-reactive antibodies were present, suggesting the possibility that antibody-dependent enhancement may increase the risk of avian-amplified transmission of SLEV in South America
F-Theorem without Supersymmetry
The conjectured F-theorem for three-dimensional field theories states that
the finite part of the free energy on S^3 decreases along RG trajectories and
is stationary at the fixed points. In previous work various successful tests of
this proposal were carried out for theories with {\cal N}=2 supersymmetry. In
this paper we perform more general tests that do not rely on supersymmetry. We
study perturbatively the RG flows produced by weakly relevant operators and
show that the free energy decreases monotonically. We also consider large N
field theories perturbed by relevant double trace operators, free massive field
theories, and some Chern-Simons gauge theories. In all cases the free energy in
the IR is smaller than in the UV, consistent with the F-theorem. We discuss
other odd-dimensional Euclidean theories on S^d and provide evidence that
(-1)^{(d-1)/2} \log |Z| decreases along RG flow; in the particular case d=1
this is the well-known g-theorem.Comment: 34 pages, 2 figures; v2 refs added, minor improvements; v3 refs
added, improved section 4.3; v4 minor improvement
Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens that do not depend on exogenous adjuvants for induction of immune responses. These are based on the concept of Immune Complex Mimics (ICM), structures that are formed between an oligomeric antigen and a monoclonal antibody (mAb) to that antigen. In this way, the roles of antigens and antibodies within the structure of immune complexes are reversed, so that a single monoclonal antibody, rather than polyclonal sera or expensive mAb cocktails can be used. We tested this approach in the context of Mycobacterium tuberculosis (MTB) infection by linking the highly immunogenic and potentially protective Ag85B with the oligomeric Acr (alpha crystallin, HspX) antigen. When combined with an anti-Acr monoclonal antibody, the fusion protein formed ICM which bound to C1q component of the complement system and were readily taken up by antigen-presenting cells in vitro. ICM induced a strong Th1/Th2 mixed type antibody response, which was comparable to cholera toxin adjuvanted antigen, but only moderate levels of T cell proliferation and IFN-Ξ³ secretion. Unfortunately, the systemic administration of ICM did not confer statistically significant protection against intranasal MTB challenge, although a small BCG-boosting effect was observed. We conclude that ICM are capable of inducing strong humoral responses to incorporated antigens and may be a suitable vaccination approach for pathogens other than MTB, where antibody-based immunity may play a more protective role
The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement
Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward-associated dopamine (DA) release in the striatum. Twenty-six healthy controls (HCs) and 10 unmedicated subjects with major depressive disorder (MDD) completed two positron emission tomography (PET) scans with [11C]raclopride using the bolus plus constant infusion method. On one occasion subjects completed a sensorimotor task (control condition) and on another occasion subjects completed a gambling task (reward condition). A linear regression analysis controlling for age, sex, diagnosis, and self-reported anhedonia indicated that during receipt of unpredictable monetary reward the glycine allele was associated with a greater reduction in D2/3 receptor binding (i.e., increased reward-related DA release) in the middle (anterior) caudate (p<0.01) and the ventral striatum (p<0.05). The possible functional effect of the ser9gly polymorphism on DA release is consistent with previous work demonstrating that the glycine allele yields D3 autoreceptors that have a higher affinity for DA and display more robust intracellular signaling. Preclinical evidence indicates that chronic stress and aversive stimulation induce activation of the DA system, raising the possibility that the glycine allele, by virtue of its facilitatory effect on striatal DA release, increases susceptibility to hyperdopaminergic responses that have previously been associated with stress, addiction, and psychosis
Doom and Boom on a Resilient Reef: Climate Change, Algal Overgrowth and Coral Recovery
Background: Coral reefs around the world are experiencing large-scale degradation, largely due to global climate change, overfishing, diseases and eutrophication. Climate change models suggest increasing frequency and severity of warming-induced coral bleaching events, with consequent increases in coral mortality and algal overgrowth. Critically, the recovery of damaged reefs will depend on the reversibility of seaweed blooms, generally considered to depend on grazing of the seaweed, and replenishment of corals by larvae that successfully recruit to damaged reefs. These processes usually take years to decades to bring a reef back to coral dominance
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