5,311 research outputs found

    Genetic and genomic approaches to understanding drug resistance in parasites

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    reconciling party autonomy and the international rule of law

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    This paper focuses on one particular issue which has arisen in the course of the ongoing debate on the reform of investor-State dispute settlement (ISDS), namely that of the appointment of arbitrators. Taking as its starting point that there now exists tentative consensus that the present system for the appointment of arbitrators either causes or exacerbates certain problematic aspects of the current ISDS system, the paper explores one option for reform, namely the introduction of an independent panel for the selection of investment arbitrators. In doing so, it is argued that a shift in the normative basis of the rules governing appointments is required in order to accommodate the principles of party autonomy and the international rule of law. Such reform, while not completely removing the initiative that parties presently enjoy, is the most efficient way to introduce rule of law considerations such as a measure of judicial independence into the current appointments system. This, it is argued, would in turn help to address some of the problematic features of the appointment of arbitrators in ISDS

    Long Run Relationships Between City Office Rents and The Economy In The UK – Creating a Database for Research

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    This paper sets out progress during the first eighteen months of doctoral research into the City of London office market. The overall aim of the research is to explore relationships between office rents and the economy in the UK over the last 150 years. To do this, a database of lettings has been created from which a long run index of City office rents can be constructed. With this index, it should then be possible to analyse trends in rents and relationships with their long run determinants. The focus of this paper is on the creation of the rent database. First, it considers the existing secondary sources of long run rental data for the UK. This highlights a lack of information for years prior to 1970 and the need for primary data collection if earlier periods are to be studied. The paper then discusses the selection of the City of London and of the time period chosen for research. After this, it describes how a dataset covering the period 1860-1960 has been assembled using the records of property companies active in the City office market. It is hoped that, if successful, this research will contribute to existing knowledge on the long run characteristics of commercial real estate. In particular, it should add a price dimension (rents) to the existing long run information on stock/supply and investment. Hence, it should enable a more complete picture of the development and performance of commercial real estate through time to be gained.office rent, City of London, property market history

    Evaluating the Effectiveness of Common Structures in Property Portfolio Construction

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    A good portfolio structure enables an investor to diversify more effectively and understand systematic influences on their performance. However, in the property market, the choice of structure is affected by data constraints and convenience. Using individual return data, this study tests the hypothesis that some common structures in the UK do not explain a significant amount about property returns. It is found that, in the periods studied, not all the structures were effective and, for the annual returns, no structures were significant in all periods. The results suggest that the drivers represented by the structures take some time to be reflected in individual property returns. They also confirm the results of other studies in finding property type a much stronger factor in explaining returns than regions.property returns, portfolio structure

    PeX 1. Multi-spectral expansion of residual speckles for planet detection

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    The detection of exoplanets in coronographic images is severely limited by residual starlight speckles. Dedicated post-processing can drastically reduce this "stellar leakage" and thereby increase the faintness of detectable exoplanets. Based on a multi-spectral series expansion of the diffraction pattern, we derive a multi-mode model of the residuals which can be exploited to estimate and thus remove the residual speckles in multi-spectral coronographic images. Compared to other multi-spectral processing methods, our model is physically grounded and is suitable for use in an (optimal) inverse approach. We demonstrate the ability of our model to correctly estimate the speckles in simulated data and demonstrate that very high contrasts can be achieved. We further apply our method to removing speckles from a real data cube obtained with the SPHERE IFS instrument.Comment: accepted for publication in MNRAS on 25th of August 2017, 17 pages, 15 figure

    Performance Analysis of Cone Detection Algorithms

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    Many algorithms have been proposed to help clinicians evaluate cone density and spacing, as these may be related to the onset of retinal diseases. However, there has been no rigorous comparison of the performance of these algorithms. In addition, the performance of such algorithms is typically determined by comparison with human observers. Here we propose a technique to simulate realistic images of the cone mosaic. We use the simulated images to test the performance of two popular cone detection algorithms and we introduce an algorithm which is used by astronomers to detect stars in astronomical images. We use Free Response Operating Characteristic (FROC) curves to evaluate and compare the performance of the three algorithms. This allows us to optimize the performance of each algorithm. We observe that performance is significantly enhanced by up-sampling the images. We investigate the effect of noise and image quality on cone mosaic parameters estimated using the different algorithms, finding that the estimated regularity is the most sensitive parameter. This paper was published in JOSA A and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/abstract.cfm?msid=224577. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.Comment: 13 pages, 7 figures, 2 table
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