La feuille 52 de la carte de Cassini : valorisation - Flâneries hydrographiques sur les pas de Cassini

Jean-Michel Delaveau, géographe (UCA), propose une (re)découverte du bassin hydrographique de la région de Clermont-Ferrand en comparant les données géohistoriques de la carte de Cassini et des représentations actuelles

TMEM126A is a mitochondrial located mRNA (MLR) protein of the mitochondrial inner membrane

International audienceBackground: Hereditary optic neuropathies (HONs) are a heterogeneous group of disorders that affect retinal ganglion cells (RGCs) and axons that form the optic nerve. Leber's Hereditary Optic Neuropathy and the autosomal dominant optic atrophy related to OPA1 mutations are the most common forms. Nonsyndromic autosomal recessive optic neuropathies are rare and their existence has been long debated. We recently identified the first gene responsible for these conditions, TMEM126A. This gene is highly expressed in retinal cellular compartments enriched in mitochondria and supposed to encode a mitochondrial transmembrane protein of unknown function. Methods: A specific polyclonal antibody targeting the TMEM126A protein has been generated. Quantitative fluorescent in situ hybridization, cellular fractionation, mitochondrial membrane association study, mitochondrial sub compartmentalization analysis by both proteolysis assays and transmission electron microscopy, and expression analysis of truncated TMEM126A constructs by immunofluorescence confocal microscopy were carried out. Results: TMEM126A mRNAs are strongly enriched in the vicinity of mitochondria and encode an inner mitochondrial membrane associated cristae protein. Moreover, the second transmembrane domain of TMEM126A is required for its mitochondrial localization. Conclusions: TMEM126A is a mitochondrial located mRNA (MLR) that may be translated in the mitochondrial surface and the protein is subsequently imported to the inner membrane. These data constitute the first step toward a better understanding of the mechanism of action of TMEM126A in RGCs and support the importance of mitochondrial dysfunction in the pathogenesis of HON. General significance: Local translation of nuclearly encoded mitochondrial mRNAs might be a mechanism for rapid onsite supply of mitochondrial membrane proteins. (C) 2013 Elsevier B.V. All rights reserved

A GIS reconstruction of the Cassini "Carte de France" sheet No. 52

The Cassini Carte de France provides a detailed description of French territory in the mid-18th century. This dataset is the result of an experiment conducted on map sheet number 52, centered on the city of Clermont-Ferrand in France. The goal was to digitise the geographical content of the map in a comprehensive way for two purposes: (1) to build a large-scale vector geographical database on the space of the 18th century and (2) to thoroughly investigate the map to carry out detailed critical analysis. This resulted in the creation of a renewed version of sheet 52. A renewed map (enlarged to a scale of 1:69000) mimicking the original style has been built from the extracted vector geographical data. This digital map is supplemented with an index of all the places it contains, for an easier reading. This dataset is composed of an archive containing: - all vector geographical data extracted from geo-referenced plate number 52; - the QGIS project to create the digital map; - the sources of a poster presented at International Cartographic Conference in 2019; - the sources of the full version of the digital map (with legend and title) and its index

Recent developments in the ABINIT software package

ABINIT is a package whose main program allows one to find the total energy, charge density, electronic structure and many other properties of systems made of electrons and nuclei, (molecules and periodic solids) within Density Functional Theory (DFT), Many-Body Perturbation Theory (GW approximation and Bethe–Salpeter equation) and Dynamical Mean Field Theory (DMFT). ABINIT also allows to optimize the geometry according to the DFT forces and stresses, to perform molecular dynamics simulations using these forces, and to generate dynamical matrices, Born effective charges and dielectric tensors. The present paper aims to describe the new capabilities of ABINIT that have been developed since 2009. It covers both physical and technical developments inside the ABINIT code, as well as developments provided within the ABINIT package. The developments are described with relevant references, input variables, tests and tutorials