Enterprise Integration in Business Education: Design and Outcomes of a Capstone ERP-based Undergraduate e-Business Management Course

This article describes the design, delivery, and outcomes of a course on enterprise integration at the senior undergraduate level in the e-business concentration in the University of New Brunswick\u27s Faculty of Business. The course aims to provide education to the young business manager regarding the process of adoption and exploitation of an ERP or enterprise-wide software system. The course is deliberately business-centric rather than technology-oriented. It contains two streams: a management component based on readings and discussion, and a hands-on laboratory component in which students individually configure a firm. We evaluated students\u27 performance in three areas: completion of a learning log containing literature summaries and reflections on individual learning, completion of configuration exercises on SAP R/3, and completion of a take-home business case. We offer several suggestions to potential providers of enterprise integration education to business students. First, do not underestimate the considerable operational requirements of a lab-based ERP course. Second, because no business-oriented curriculum for enterprise integration business education is presently available on the market, teachers must be prepared to develop one. Third, students have very different learning needs with respect to ERP. The combination of hands-on lab learning and management learning via reading, discussions, and cases is very powerful but it is a challenge to balance the two streams and to relate the lab learnings with the management learnings

Apple Cider Vinegar Weight Loss Drinks: Portrayal on Pinterest

Apple cider vinegar has shown great promise for weight loss in controlled lab settings, yet these claims are widely shared on social media and may not yield the same benefits. This study used directed content analysis to examine how apple cider vinegar weight loss drinks were portrayed on Pinterest, a social media website utilized to bookmark online content. Using the search terms “apple cider vinegar weight loss drinks,” researchers sampled every fifth pin to collect 200 relevant pins. A codebook was developed, pilot tested and used to code pins. Of the 200 pins, the majority of pins (66%) positively portrayed the effectiveness of apple cider vinegar drinks for weight loss, and 36% contained images of a drink. 60% of pins made weight-loss claims for specific pounds lost; however, most of those pins did not present a particular number of pounds that an individual will lose from drinking apple cider vinegar. Also, a time frame for weight loss promised was only present in 15% of pins. In this sample of pins, 6% of pins had comments. Social media is a powerful source of health information. However, this study demonstrated evidence of the propagation of misleading and potentially dangerous weight loss methods. This study revealed widespread interest and acceptance of insufficient weight loss drink information

Apple Cider Vinegar Weight Loss Drinks on Pinterest

Background: More than a third of adults in the U.S. are currently trying to lose weight. Social media, specifically Pinterest with more than 322 million users, has changed the way people seek health information specifically weight loss. Apple cider vinegar has shown great promise for weight loss in controlled lab settings, yet these claims are widely shared on social media and may not yield the same benefits. Purpose: This study used directed content analysis to examine how apple cider vinegar weight loss drinks were portrayed on Pinterest, a social media website used to bookmark online content. Methods: Using the search terms, “apple cider vinegar weight loss drinks,” researchers sampled every fifth pin to collect 200 relevant pins. A codebook was developed, pilot tested, and used to code pins. Results: Of the 200 pins, the majority of pins (66%) positively portrayed the effectiveness of apple cider vinegar drinks for weight loss, and 36% contained images of a drink. Weight loss claims for specific pounds lost were made in 60% of pins, however the majority of those pins did not present a specific number of pounds that will be lost from drinking apple cider vinegar. In addition, a time frame for weight loss promised was only present in 15% of pins. In this sample of pins, 6% of pins had comments. Conclusions: Social media is a powerful source of health information, however, there is evidence of misleading and potentially dangerous weight loss methods being propagated. This study revealed widespread interest and acceptance of insufficient weight loss drink information

Review of boat wake wave impacts on shoreline erosion and potential solutions for the Chesapeake Bay

[Introduction] The goal of this technical review was to evaluate 1) the potential impacts of boat generated waves on shoreline stability and attendant ecosystem properties, and 2) policy options to minimize any adverse effects. We reviewed available literature, examined relevant data and information from Chesapeake Bay, discussed modeling approaches and highlighted data gaps to further quantify effects on shorelines and ecosystems, and detailed available management and policy actions to minimize potential boat wake impacts. The major findings are: 1) The literature review indicates an unequivocal connection between boat wake energy and shoreline erosion, sediment resuspension and nearshore turbidity. 2) There is not currently enough data to determine the extent (spatially and in magnitude) to which boat wakes are contributing to erosion or turbidity of the Chesapeake Bay 3) Recommended next steps are to identify highly vulnerable waterways and implement management or policy actions to minimize adverse effects

Defining boat wake impacts on shoreline stability toward management and policy solutions

Coastal economies are often supported by activities that rely on commercial or recreational vessels to move people or goods, such as shipping, transportation, cruising, and fishing. Unintentionally, frequent or intense vessel traffic can contribute to erosion of coastlines; this can be particularly evident in sheltered systems where shoreline erosion should be minimal in the absence of boat waves. We reviewed the state of the science of known effects of boat waves on shoreline stability, examined data on erosion, turbidity, and shoreline armoring patterns for evidence of a response to boat waves in Chesapeake Bay, and reviewed existing management and policy actions in Chesapeake Bay and nearby states to make recommendations for actions to minimize boat wake impacts. In the literature, as well as in our analyses, boat wake energy may be linked to elevated turbidity and shoreline erosion, particularly in narrow waterways. In Chesapeake Bay, three lines of evidence suggest boat waves are contributing to shoreline erosion and poor water clarity in some Bay creeks and tributaries: 1) nearshore turbidity was elevated in many waterways during periods of expected high boating activity, 2) armoring was placed along about a quarter of the low energy shorelines of three examined tidal creeks that are exposed to relatively high boating pressure, and 3) 15% of the shorelines we examined throughout the Bay (9000 km) are low energy shorelines that are experiencing high erosion (≥0.3 m/yr) that cannot be attributed to wind wave energy. Still, there remain significant data gaps that preclude the determination of the overall contribution of boat waves to shoreline erosion throughout the Bay, notably, shoreline erosion data in low energy waterways, recreational boating traffic patterns, and nearshore bathymetry. Interim protective measures can be (and have been) applied in high risk waterways, such as small, low energy waterways that have high recreational boating activity, to help reduce shoreline erosion. Policy options used in Bay states and elsewhere include setbacks from the shore, wake restrictions, and speed restrictions; other more restrictive policies may include prohibition on boats of a certain size or limiting the number of passages. Finally, a systems-approach to boat wake impact management using uniform boat wake policies is likely to be the most effective for consistent shoreline protection

Collage Concert

Kennesaw State University School of Music presents the 3rd annual Collage Concert.https://digitalcommons.kennesaw.edu/musicprograms/1592/thumbnail.jp

First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxidase-B (MAO-B) appear as particularly convincing, especially if displayed by a sole agent such as ladostigil, currently in clinical trial in AD. Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). The synthesis of racemic trans PADPZ was achieved and its biological evaluation established its inhibitory activities towards both (h)AChE (IC50 = 0.4 uM) and (h)MAO-B (IC50 = 6.4 uM)

Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides

Aminoglycosides are broad-spectrum antibiotics commonly used for the treatment of serious bacterial infections. Decades of clinical use have led to the widespread emergence of bacterial resistance to this family of drugs limiting their efficacy in the clinic. Here, we report the development of a methodology that utilizes aminoglycoside acetyltransferases (AACs) and unnatural acyl coenzyme A analogues for the chemoenzymatic generation of N-acylated aminoglycoside analogues. Generation of N-acylated aminoglycosides is followed by a simple qualitative test to assess their potency as potential antibacterials. The studied AACs (AAC(6′)-APH(2′′) and AAC(3)-IV) show diverse substrate promiscuity towards a variety of aminoglycosides as well as acyl coenzyme A derivatives. The enzymes were also used for the sequential generation of homo- and hetero-di-N-acylated aminoglycosides. Following the clinical success of the N-acylated amikacin and arbekacin, our chemoenzymatic approach offers access to regioselectively N-acylated aminoglycosides in quantities that allow testing of the antibacterial potential of the synthetic analogues making it possible to decide which molecules will be worth synthesizing on a larger scale.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64528/1/cbic_200900584_sm_miscellaneous_information.pd

Nitrogen-induced terrestrial eutrophication: cascading effects and impacts on ecosystem services

Human activity has significantly increased the deposition of nitrogen (N) on terrestrial ecosystems over pre-industrial levels leading to a multitude of effects including losses of biodiversity, changes in ecosystem functioning, and impacts on human well-being. It is challenging to explicitly link the level of deposition on an ecosystem to the cascade of ecological effects triggered and ecosystem services affected, because of the multitude of possible pathways in the N cascade. To address this challenge, we report on the activities of an expert workshop to synthesize information on N-induced terrestrial eutrophication from the published literature and to link critical load exceedances with human beneficiaries by using the STressor–Ecological Production function–final ecosystem Services Framework and the Final Ecosystem Goods and Services Classification System (FEGS-CS). We found 21 N critical loads were triggered by N deposition (ranging from 2 to 39 kg N·ha−1·yr−1), which cascaded to distinct beneficiary types through 582 individual pathways in the five ecoregions examined (Eastern Temperate Forests, Marine West Coast Forests, Northwestern Forested Mountains, North American Deserts, Mediterranean California). These exceedances ultimately affected 66 FEGS across a range of final ecosystem service categories (21 categories, e.g., changes in timber production, fire regimes, and native plant and animal communities) and 198 regional human beneficiaries of different types. Several different biological indicators were triggered in different ecosystems, including grasses and/or forbs (33% of all pathways), mycorrhizal communities (22%), tree species (21%), and lichen biodiversity (11%). Ecoregions with higher deposition rates for longer periods tended to have more numerous and varied ecological impacts (e.g., Eastern Temperate Forests, eight biological indicators) as opposed to other ecoregions (e.g., North American Deserts and Marine West Coast Forests each with one biological indicator). Nonetheless, although ecoregions differed by ecological effects from terrestrial eutrophication, the number of FEGS and beneficiaries impacted was similar across ecoregions. We found that terrestrial eutrophication affected all ecosystems examined, demonstrating the widespread nature of terrestrial eutrophication nationally. These results highlight which people and ecosystems are most affected according to present knowledge, and identify key uncertainties and knowledge gaps to be filled by future research

Evaluation of Total Daily Dose and Glycemic Control for Patients Taking U-500 Regular Insulin Admitted to the Hospital

OBJECTIVE: Patients using U-500 regular insulin are severely insulin resistant, requiring high doses of insulin. It has been observed that a patient\u27s insulin requirements may dramatically decrease during hospitalization. This study sought to systematically investigate this phenomenon. METHODS: We performed a retrospective chart review of patients with U-500 insulin outpatient regimens who were admitted to the San Antonio Military Medical Center over a 5-year period. Each patient\u27s outpatient total daily dose (TDD) of insulin was compared to the average inpatient TDD. The outpatient estimated average glucose (eAG) was calculated from the glycated hemoglobin (HbA1c) and compared to the average inpatient glucose. RESULTS: There were 27 patients with a total of 62 separate admissions. The average age was 64.4 years, with a mean body mass index of 38.9 kg/m CONCLUSION: U-500 insulin is prone to errors in the hospital setting, so conversion to U-100 insulin is a preferred option. Despite a significant reduction in insulin TDD, these patients had clinically similar glucose levels. Therefore, patients taking U-500 insulin as an outpatient can be converted to a U-100 basal-bolus regimen with at least a 50% reduction of their outpatient TDD. ABBREVIATIONS: BG = blood glucose eAG = estimated average glucose HbA1c = glycated hemoglobin NPO = nil per os SPSS = Statistical Package for the Social Sciences TDD = total daily dose