Utilitarianism and animal cruelty: Further doubts

Utilitarianism has an apparent pedigree when it comes to animal welfare. It supports the view that animal welfare matters just as much as human welfare. And many utilitarians support and oppose various practices in line with more mainstream concern over animal welfare, such as that we should not kill animals for food or other uses, and that we ought not to torture animals for fun. This relationship has come under tension from many directions. The aim of this article is to add further considerations in support of that tension. I suggest three ways in which utilitarianism comes significantly apart from mainstream concerns with animal welfare. First, utilitarianism opposes animal cruelty only when it offers an inefficient ratio of pleasure to pain; while this may be true of eating animal products, it is not obviously true of other abuses. Second, utilitarianism faces a familiar problem of the inefficacy of individual decisions; I consider a common response to this worry, and offer further concerns. Finally, the common utilitarian argument against animal cruelty ignores various pleasures that humans may get from the superior status that a structure supporting exploitation confers

Asphericity and clumpiness in the winds of Luminous Blue Variables

We present the first systematic spectropolarimetric study of Luminous Blue Variables (LBVs) in the Galaxy and the Magellanic Clouds, in order to investigate the geometries of their winds. We find that at least half of our sample show changes in polarization across the strong H$\alpha$ emission line, indicating that the light from the stars is intrinsically polarized and therefore that asphericity already exists at the base of the wind. Multi-epoch spectropolarimetry on four targets reveals variability in their intrinsic polarization. Three of these, AG Car, HR Car and P Cyg, show a position angle (PA) of polarization which appears random with time. Such behaviour can be explained by the presence of strong wind-inhomogeneities, or `clumps' within the wind. Only one star, R 127, shows variability at a constant PA, and hence evidence for axi-symmetry as well as clumpiness. However, if viewed at low inclination, and at limited temporal sampling, such a wind would produce a seemingly random polarization of the type observed in the other three stars. Time-resolved spectropolarimetric monitoring of LBVs is therefore required to determine if LBV winds are axi-symmetric in general. The high fraction of LBVs ($>$ 50%) showing intrinsic polarization is to be compared with the lower $\sim$ 20-25 % for similar studies of their evolutionary neighbours, O supergiants and Wolf-Rayet stars. We anticipate that this higher incidence is due to the lower effective gravities of the LBVs, coupled with their variable temperatures within the bi-stability jump regime. This is also consistent with the higher incidence of wind asphericity that we find in LBVs with strong H$\alpha$ emission and recent (last $\sim$ 10 years) strong variability.Comment: 20 pages, 12 figures, accepted by A&

The validity of two compartment model methods of body composition as compared to magnetic resonance imaging in Asian Indian versus Caucasian males

Background: The two-compartment (2C) model is a relatively accessible, inexpensive and time efficient method for body composition measurement. There is very little validated research on the 2C model in Asian Indians: a high risk population in terms of obesity and related disorders. This highlights the need for valid estimates of body composition from the 2C model. Purpose: The goal was to compare 2C model (predictor) estimates of body composition to those from magnetic resonance imaging (MRI) (criterion), an established gold standard measure of total adiposity in order to determine the validity of the 2C model in the Asian Indian population. From this data it is hoped that a correction equation may be determined for more accurate prediction of Asian Indian body composition using 2C model methods. Methods: 21 males (10 Asian Indian and 11 Caucasian, aged 18-55 yrs) had estimates of percent body fat from 2C methods (sum of four skinfolds and anthropometry, bioelectrical impedance analysis [Bodystat 1500 and Tanita segmental impedance analyser], air displacement plethysmography [Bod Pod] and hydrostatic weighing) compared to MRI measured body composition values. Agreement was assessed using multiple linear regression analysis and Bland-Altman plots. Differences were assessed using repeated measures analysis of variance. Results: Regression analysis showed air displacement plethysmography predicts MRI body composition in Caucasian males (adjusted r2 = 0.74; SEE =3.27 ). In Asian Indians, tricep skinfold thickness and hydrostatic weighing predicted MRI body composition with a low prediction error (adjusted r2 = 0.90; SEE =1.75). Despite strong correlations and no significant difference between mean differences of the 2C methods, used in the prediction model, and MRI, BlandAltman plots revealed no acceptable limits of agreement between the methods. Asian Indian body composition was underestimated by all two compartment devices compared to MRI. Conclusion: There appears to be potential for the use of tricep skinfold thickness and hydrostatic weighing to predict an established reference measure (MRI) in the high risk Asian Indian population. The 2C model underestimated Asian Indian body composition, this suggests that un-validated, the 2C model may misidentify obesity and in turn health risk. However the small sample tested, has implications for the interpretation of the findings. Further investigation is required with a greater sample size to validate the 2C model against an established reference measure such as MRI as there is currently little published validation data in this ethnic group

Dietary glycaemic carbohydrate, physical activity and cardiometabolic health in postpubertal adolescents

A thesis submitted to the University of Bedfordshire, in partial fulfilment of the requirements for the degree of Doctor of PhilosophyThe principle aims of this work were two fold; firstly to identify the current dietary intakes (specifically dietary glycaemic carbohydrate (CHO)) and physical activity (PA) and cardiorespiratory fitness (CRF) levels of a UK, postpubertal, adolescent population (n = 105) and assess the relationship between these factors, adiposity and cardiometabolic health. Diet and health relationships were assessed whilst accounting for energy misreporting and controlling for levels of PA and CRF. The effect of excluding dietary misreporters on the associations between glycaemic CHO and health was assessed whilst comparing an established technique (the Goldberg equation) to a novel approach (the ratio of energy intake (EI) to energy expenditure (EE)), which utilised RT3 accelerometry data (EI:EE(RT3)). Associations of PA and metabolic risk factors were also assessed whilst comparing two child specific PA thresholds for the assessment of PA subcomponents. Secondly, the impact of a flexible, ad libitum, low GI dietary intervention on cardiometabolic health was examined in an „at risk‟, overweight, postpubertal, adolescent population. Glycaemic index (GI) but not glycaemic load (GL) was shown to be associated significantly with anthropometric measures (body mass index (BMI), waist circumference (WC)) and adiposity (body fat percentage (BF%)) in this general group of post-pubertal adolescents from Bedfordshire. When adjusting for dietary intake, CRF was also associated with adiposity but PA was not. The prevalence of misreporting varied depending on the method used to assess the validity of dietary intakes; between 23% and 31% increasing to 62.1% (in overweight) of adolescents under reported energy intakes and up to 11.1% over reported. The novel application of a triaxial accelerometer to measure EE resulted in more under and over reporters being identified than when compared to the widely used Goldberg equation. Increased dietary GI was associated with increased odds of having a high WC; however, associations between GL and other risk factors were less clear; no associations with risk were observed. Excluding dietary misreporters from analysis had important implications for these associations. Only after removal of misreporters by EI:EE(RT3) was a borderline significant positive association between GL and blood glucose (BG) revealed using multiple analysis of covariance (MANCOVA), that was not present in prior analyses. Increased GI (moderate vs low GI intake) was significantly associated with reduced high density lipoprotein cholesterol (HDL) and increased triglyceride (TG) levels (borderline significant) after removal of misreporters. In addition, using different PA thresholds to assess PA intensity resulted in different relationships between PA subcomponents and metabolic risk factors. Regardless of the threshold used, evidence suggested that limiting sedentary (SED) behaviour and engaging in moderate to vigorous PA (MVPA) is beneficial for blood pressure (BP) in this adolescent population. Additionally, irrespective of the threshold utilised, higher levels of vigorous PA (VPA) were associated with reduced odds of having a high clustered risk score and the associations observed between CRF and risk factors were stronger than those observed with PA. Despite a lack of significant improvement in individual metabolic risk factors as a result of the low GI (LGI) dietary intervention, there was a significant reduction in clustered risk score for the LGI group at week 12. A borderline significant improvement in glycated haemoglobin (HbA1c) was also observed as a result of the LGI intervention compared to those in the control group. Conversely, there appeared to be an unfavourable effect of the LGI diet on fasting insulin levels and thus the diet‟s impact on health overall is unclear. The small sample size of this randomised controlled trial (RCT) means that caution is required when interpreting the results. These data suggest that future research in this age group should target improvements in CRF and a lower dietary GI to reduce adiposity. Controlling for dietary misreporting appears to have a significant impact on associations of glycaemic CHO and cardiometabolic health and should be an important consideration of future research. The low GI intervention may be an effective approach for reducing glycaemic CHO, whilst maintaining a healthy macronutrient intake, in comparison to more restricted dietary regimens published in the literature. However, the impact of this regime needs to be confirmed utilising a larger sample of adolescents. This may provide a useful approach for future research aiming to assess the impact of reduced GI and GL

Painful diabetic neuropathy: Exploring management options

Painful diabetic neuropathy (PDN) is one microvascular complication of diabetes mellitus (DM) and the focus of this thesis. PDN is a neuropathic pain condition characterised by severe burning pain in the feet and sometimes hands. It has significant impacts on peoples’ mobility, sleep quality and overall quality of life. The personal and societal burden associated with DM and PDN is predicated to rise as prevalence rates increase.Pharmacological management of PDN is often less than optimal, and people are left with few strategies to cope. Multidisciplinary pain management programmes (PMPs) use physical activity and psychological coping strategies to help people live better with persistent pain, yet people with PDN are rarely referred. It is unknown whether these strategies would be appropriate to help people live with PDN. This thesis aimed to: 1) locate and appraise all literature relating to physical activity and psychological coping strategies in PDN; 2) interview people with PDN and explore how PDN impacted on their lives; 3) explore the perspectives of patients and clinicians on the relevance of PMP approaches; and 4) explore patients’ treatment priorities and whether these might be addressed by PMP strategies.To address these aims, firstly a systematic literature review was conducted. The review identified a paucity of studies investigating physical activity or psychological coping strategies for PDN. Two interview studies were conducted, and data were analysed using thematic analysis (TA). A study with patients (n=23) found the impacts of PDN were wide ranging, people had experimented with many coping strategies unsuccessfully and there was some scepticism that PMP strategies were relevant to PDN, though few participants had direct experience of them. The second study interviewed specialist diabetes and pain clinicians and representatives from primary care (n=19). Clinicians relied primarily on medication strategies and did not have alternatives when these failed. Diabetes clinicians highlighted that people with PDN were medically complex patients and were at risk of tissue damage from too much physical activity. Pain clinicians felt PMP strategies could be adapted to suit the population with PDN.Informed by the patient interview study, an Internet survey was developed to explore the management priorities of people with PDN (n=63 respondents). Sleep disturbance was the top priority in all subgroups analysed. There were six impacts most frequently prioritised by respondents, which did not include pain. Potential clinical management strategies for these impacts have been described, and suggestions made for future research. This thesis has shown a scarcity of existing evidence for non-pharmacological strategies in the management of PDN. PMP strategies were not necessarily viewed as appropriate by patient participants. The impacts prioritized by people with PDN could however be matched to management strategies from other conditions where persistent pain is common. There is no a priori reason why these strategies could not be trialled with PDN. Managing the impacts of PDN on peoples’ lives remains a complex process