13 research outputs found
Sounds or Silence? Auditory Stimulus Effects on Fine Motor Skills
- Author
- Publication venue
- Publication date
- 06/03/2020
- Field of study
Unlike vision where we can select stimuli to either attend to or to avoid altogether, audition provides no such opportunity. Auditory stimuli, which permeate all aspects of life, can spur movement and set a pace for individuals performing tasks. If qualities of auditory stimulation were specifically controlled, task performance may be directly affected. The present study examined different controlled sound conditions during performance on a manual dexterity task (the game of Operation). It was found that, indeed, certain sound qualities do affect performance
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
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- Williamson James D
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- Woodward Robert
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- Wright Kim
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- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Pretesting students to improve teaching and learning
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
A Molecular and Structural Mechanism for G Protein-mediated Microtubule Destabilization*
- Author
- Allen
- Allen
- Bianchi
- Chen
- Chen
- Conde
- Dave
- David-Pfeuty
- Donati
- Graziano
- Grishina
- Guo
- Hamm
- Hu
- Jaworski
- Layden
- Leslie Wilson
- Lim
- Linder
- Lopus
- Lopus
- Manu Lopus
- Margolis
- Mark M. Rasenick
- Mejillano
- Miller
- Murphy
- Nogales
- Piao
- Poulain
- Rahul H. Davé
- Rasenick
- Roychowdhury
- Roychowdhury
- Skiba
- Skiba
- Smrcka
- Sonya Davé
- Sunahara
- Suter
- Tesmer
- van Rossum
- Wang
- Witchuda Saengsawang
- Xiang
- Yan
- Yenjerla
- Yenjerla
- Yu
- Publication venue
- American Society for Biochemistry and Molecular Biology
- Publication date
- Field of study
The heterotrimeric, G protein-coupled receptor-associated G protein, Gαs, binds tubulin with nanomolar affinity and disrupts microtubules in cells and in vitro. Here we determine that the activated form of Gαs binds tubulin with a KD of 100 nm, stimulates tubulin GTPase, and promotes microtubule dynamic instability. Moreover, the data reveal that the α3–β5 region of Gαs is a functionally important motif in the Gαs-mediated microtubule destabilization. Indeed, peptides corresponding to that region of Gαs mimic Gαs protein in activating tubulin GTPase and increase microtubule dynamic instability. We have identified specific mutations in peptides or proteins that interfere with this process. The data allow for a model of the Gαs/tubulin interface in which Gαs binds to the microtubule plus-end and activates the intrinsic tubulin GTPase. This model illuminates both the role of tubulin as an “effector” (e.g. adenylyl cyclase) for Gαs and the role of Gαs as a GTPase activator for tubulin. Given the ability of Gαs to translocate intracellularly in response to agonist activation, Gαs may play a role in hormone- or neurotransmitter-induced regulation of cellular morphology
PICC-associated Bloodstream Infections: Prevalence, Patterns, and Predictors
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The Treatment of Minimum Wage in Principles of Economics Textbooks Revisited
- Author
- A Couch
- A Paul
- Alan B Krueger
- Alison Wellington
- Brendan Nyhan
- Charles Brown
- Dan Berrett
- Dani Rodik
- Daniel S Hamermesh
- David Card
- David Card
- David Card
- David Neumark
- David Neumark
- David Neumark
- Edwin Dolan
- George J Stigler
- Gerald W Stone
- Gregory N Mankiw
- H Robert
- Irvin Tucker
- James D Gwartney
- Jane S Lopus
- Jared Berstein
- John B Taylor
- Joseph J Sabia
- Karl E Case
- Manfred Keil
- Michael Parkin
- O&apos
- Paul Krugman
- R
- R Bradley
- R Campbell
- R Finis
- Richard V Burkhauser
- Richard V Burkhauser
- Robert Hall
- Robert Whaples
- Robin Bade
- Roger A Arnold
- Roger Leroy Miller
- Thomas R Michl
- Tyler Cowen
- V Richard
- Veronika Dolar
- William A Mceachern
- William Baumol
- William Boyes
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Intermediate Macro Texts and the Economic Crisis of 2008-09
- Author
- Alan Greenspan
- Andrew B Abel
- Andrew J Policano
- Ben S Bernanke
- Charles I Jones
- David J Hoaas
- David Romer
- J Delong
- J. Michael Miller
- Jack Reardon
- James C Cooper
- Jane S Lopus
- Jerry D. Gray
- John B Taylor
- John J Bethune
- John Keynes
- John M Barron
- Lee C Spector
- N Mankiw
- Nouriel Roubini
- Panu Kalmi
- Patricia Cohen
- Paul Krugman
- Richard T Froyen
- Robert E Hall
- Robert J Barro
- Robert J Gordon
- Roger L Miller
- Rudiger Dornbusch
- Stephen D Williamson
- Sudeep Reddy
- Vikas Bajaj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2009
- Field of study
Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)
- Author
- Bischler
- Boehle
- David J. Chaplin
- Dougherty
- Dowlati
- El-Zayat
- Ernest Hamel
- Etienne-Manneville
- Flynn
- Flynn
- Flynn
- Hadimani
- Hadimani
- Hall
- Hamel
- Hasani
- Hida
- John J. Hall
- Jordan
- Kanthou
- Kemperman
- Kevin G. Pinney
- Kremmidiotis
- La Regina
- La Regina
- Lee
- Liou
- Lopus
- Mary Lynn Trawick
- Mason
- Matthew T. MacDonough
- McGowan
- Mohlau
- Monks
- Mullica
- Ohno
- Oshumi
- Oshumi
- Patil
- Pettit
- Pettit
- Pettit
- Pettit
- Pettit
- Pettit
- Pinney
- Pinney
- Rustin
- Siemann
- Siemann
- Tozer
- Tracy E. Strecker
- Ty
- Valiron
- Vichai
- Wade
- Weisenberg
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Seasonal changes in nutrient content and concentrations in a mature deciduous tree species: Studies in almond (Prunus dulcis (Mill.) D. A. Webb)
- Author
- Alva
- Andres Olivos
- Araujo
- Benbi
- Blake L. Sanden
- Bruce D. Lampinen
- Burow
- Burrow
- CDFA
- Cheng
- Choi
- Clarisse
- Clark
- David R. Smart
- Dejong
- Delin
- Deng
- Di
- Doane
- Egea
- Esser
- Fessehazion
- Geraldson
- Gheysari
- Hawker
- Hunter
- Kang
- Kempers
- Kenneth A. Shackel
- Kester
- Li
- Lopus
- Mangiafico
- Marschner
- Meisinger
- Millard
- Millard
- Millard
- Millard
- Muhammad I. Siddiqui
- Munoz
- Neilsen
- Nightingale
- Patrick H. Brown
- Paw
- Pradubsuk
- Roccuzzo
- Rosecrance
- Rufat
- Sabbe
- Saiful Muhammad
- Schellenberg
- Sebastian Saa
- Stassen
- Tagliavini
- Theodore DeJong
- Titus
- Tromp
- Ulrich
- Ulrich
- Ulrich
- Viers
- Weinbaum
- Weinbaum
- Weinbaum
- Weinbaum
- Weinbaum
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
- Author
- A Beck
- AG Polson
- AG Polson
- AM Wu
- Amy Li
- AW Mould
- B Schröder
- B-C Lee
- Benjamin A. H. Smith
- C Büll
- C Ríos-Luci
- C. Kimberly Tsui
- CA St Pierre
- Carolyn R. Bertozzi
- CD Rillahan
- Curt R. Fischer
- D Poteryaev
- D Rabuka
- David Rabuka
- David W. Morgens
- DW Morgens
- DW Morgens
- F Loganzo
- G Li
- GD Lewis Phillips
- GM Dubowchik
- H Donaghy
- H Wang
- H Xiao
- IR Nabi
- J Lu
- JA Burger
- JMT Hyttinen
- K Kinneer
- K Liu
- K Liu
- K Wood
- KJ Hamblett
- L Li
- L Pontano Vaites
- L Wang
- LS Qi
- M Abdollahpour-Alitappeh
- M Lopus
- M Ritchie
- M Sung
- M Zhang
- Melissa Anne Gray
- Michael C. Bassik
- MP Mathew
- MS Macauley
- NG Caculitan
- OMT Pearce
- P Agarwal
- R Lyon
- R Rapiteanu
- RM Deans
- Robyn M. Barfield
- T Yoshimori
- W Zmolek
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study