10,047 research outputs found
A rebuttal--the Rsal polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training.
Reevaluating evaluative conditioning: A nonassociative explanation of conditioning effects in the visual evaluative conditioning paradigm
In 2 studies, the authors investigated whether evaluative conditioning (EC) is an associative phenomenon. Experiment 1 compared a standard EC paradigm with nonpaired and no-treatment control conditions. EC effects were obtained only when the conditioned stimulus (CS) and unconditioned stimulus (UCS) were rated as perceptually similar. However, similar EC effects were obtained in both control groups. An earlier failure to obtain EC effects was reanalyzed in Experiment 2. Conditioning-like effects were found when comparing a CS with the most perceptually similar UCSs used in the procedure but not when analyzing a CS rating with respect to the UCS with which it was paired during conditioning. The implications are that EC effects found in many studies are not due to associative learning and that the special characteristics of EC (conditioning without awareness and resistance to extinction) are probably nonassociative artifacts of the EC paradigm
Who's afraid of the big bad wolf: a prospective paradigm to test Rachman's indirect pathways in children
Rachman's theory [The conditioning theory of fear insition: a critical examination. Behav. Res. Ther. 15 (1977) 375–387] of fear acquisition suggests that fears and phobias can be acquired through three pathways: direct conditioning, vicarious learning and information/instruction. Although retrospective studies have provided some evidence for these pathways in the development of phobias during childhood [see King, Gullone, & Ollendick, Etiology of childhood phobias: current status of Rachman's three pathway's theory. Behav. Res. Ther. 36 (1998) 297–309 for a review], these studies have relied on long-term past memories of adult phobics or their parents. The current study was aimed towards developing a paradigm in which the plausibility of Rachman's indirect pathways could be investigated prospectively. In Experiment 1, children aged between 7 and 9 were presented with two types of information about novel stimuli (two monsters): video information and verbal information in the form of a story. Fear-related beliefs about the monsters changed significantly as a result of verbal information but not video information. Having established an operational paradigm, Experiment 2 looked at whether the source of verbal information had an effect on changes in fear-beliefs. Using the same paradigm, information about the monsters was provided by either a teacher, an adult stranger or a peer, or no information was given. Again, verbal information significantly changed fear-beliefs, but only when the information came from an adult. The role of information in the acquisition of fear and maintenance of avoidant behaviour is discussed with reference to modern conditioning theories of fear acquisition
The relation between adult height and haemorrhagic and ischaemic stroke in the Renfrew/Paisley study
Adult height is a useful marker of fetal growth, growth and nutrition in childhood and childhood infections. Studies reporting inverse associations between height and stroke therefore provide support for the hypothesis that exposures acting in early life are important determinants of risk of stroke. However, few studies have been able to examine the association between height and stroke subtype. We recently showed that height is inversely related to ischaemic stroke, but because of small numbers it was not possible to robustly analyse the association between height and haemorrhagic stroke. A Norwegian study has shown a stronger inverse association with haemorrhagic compared with ischaemic stroke, but adjustment for socioeconomic position was not possible. We recently reported a significant inverse association between height and stroke mortality in both men and women in the Renfrew/Paisley cohort. Here we examine the association between height and subtype of incident stroke in this cohort
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Flywheel energy storage system with homopolar electrodynamic magnetic bearing
The goal of this research was to evaluate the potential of homopolar electrodynamic magnetic bearings for flywheel energy storage systems (FESSs). The primary target was a FESS for Low Earth Orbit (LEO) satellites; however, the design can also be easily adapted for Earth-based applications. The main advantage of Homopolar Electrodynamic Bearings compared to more conventional Active Magnetic Bearings (AMB) is simplicity and very low power rating of its electronics, resulting in higher system reliability - a critical factor for space applications. For commercial applications this technologies may also be found very attractive due to a potentially lower cost compared to AMB.Center for Electromechanic
A simple model of ocean temperature re-emergence and variability
A simple stochastic one-dimensional model of interannual mid-latitude sea surface temperature (SST) variability that can be solved analytically is developed. A novel two-season approach is adopted, with the annual cycle divided into two seasons denoted summer and winter. Within each season the mixed layer depth is constant, and the transition of the mixed layer from summer to winter and vice versa is discontinuous. SST anomalies are forced by random atmospheric heat fluxes, assumed to be constant within each season for simplicity, with linear damping to represent atmospheric feedback. At the start of summer the initial SST anomaly is set equal to that at the end of the previous winter, and at the start of winter the initial temperature anomaly is found by instantaneously mixing the summer mixed layer with the heat stored below in the deeper winter mixed layer, thereby explicitly taking into account the ‘re-emergence mechanism’. Two simple auto-regressive equations for the summer and winter SST anomalies are obtained that can be easily solved. Model parameters include seasonal damping coefficients, mixed layer depths and standard deviations of the atmospheric forcing. Analytic expressions for season-to-season correlation and variability and power spectra are used to explore and illustrate the effects of the parameters quantitatively. Among the results it is found that, with regard to winter-to-winter temperature correlation, the re-emergence pathway is more influential than persistence via the summer mixed layer when the winter layer is more than twice the depth of the summer layer. With regard to winter temperature variability, the effect of a deeper winter mixed layer is to decrease the sensitivity to surface forcing and thus decrease variability, but also to increase persistence via re-emergence and thus increase variance at multidecadal scales
Psychological stress and cardiovascular disease: empirical demonstration of bias in a prospective observational study of Scottish men
Objectives: To examine the association between self perceived psychological stress and cardiovascular disease in a population where stress was not associated with social disadvantage.
Design: Prospective observational study with follow up of 21 years and repeat screening of half the cohort 5 years from baseline. Measures included perceived psychological stress, coronary risk factors, self reported angina, and ischaemia detected by electrocardiography.
Setting: 27 workplaces in Scotland.
Participants: 5606 men (mean age 48 years) at first screening and 2623 men at second screening with complete data on all measures
Main outcome measures: Prevalence of angina and ischaemia at baseline, odds ratio for incident angina and ischaemia at second screening, rate ratios for cause specific hospital admission, and hazard ratios for cause specific mortality.
Results: Both prevalence and incidence of angina increased with increasing perceived stress (fully adjusted odds ratio for incident angina, high versus low stress 2.66, 95% confidence interval 1.61 to 4.41; P for trend <0.001). Prevalence and incidence of ischaemia showed weak trends in the opposite direction. High stress was associated with a higher rate of admissions to hospital generally and for admissions related to cardiovascular disease and psychiatric disorders (fully adjusted rate ratios for any general hospital admission 1.13, 1.01 to 1.27, cardiovascular disease 1.20, 1.00 to 1.45, and psychiatric disorders 2.34, 1.41 to 3.91). High stress was not associated with increased admission for coronary heart disease (1.00, 0.76-1.32) and showed an inverse relation with all cause mortality, mortality from cardiovascular disease, and mortality from coronary heart disease, that was attenuated by adjustment for occupational class (fully adjusted hazard ratio for all cause mortality 0.94, 0.81 to 1.11, cardiovascular mortality 0.91, 0.78 to 1.06, and mortality from coronary heart disease 0.98, 0.75 to 1.27).
Conclusions: The relation between higher stress, angina, and some categories of hospital admissions probably resulted from the tendency of participants reporting higher stress to also report more symptoms. The lack of a corresponding relation with objective indices of heart disease suggests that these symptoms did not reflect physical disease. The data suggest that associations between psychosocial measures and disease outcomes reported from some other studies may be spurious
Solar Coronal Structures and Stray Light in TRACE
Using the 2004 Venus transit of the Sun to constrain a semi-empirical
point-spread function for the TRACE EUV solar telescope, we have measured the
effect of stray light in that telescope. We find that 43% of 171A EUV light
that enters TRACE is scattered, either through diffraction off the entrance
filter grid or through other nonspecular effects. We carry this result forward,
via known-PSF deconvolution of TRACE images, to identify its effect on analysis
of TRACE data. Known-PSF deconvolution by this derived PSF greatly reduces the
effect of visible haze in the TRACE 171A images, enhances bright features, and
reveals that the smooth background component of the corona is considerably less
bright (and hence much more rarefied) than commonly supposed. Deconvolution
reveals that some prior conlclusions about the Sun appear to have been based on
stray light in the images. In particular, the diffuse background "quiet corona"
becomes consistent with hydrostatic support of the coronal plasma; feature
contrast is greatly increased, possibly affecting derived parameters such as
the form of the coronal heating function; and essentially all existing
differential emission measure studies of small features appear to be affected
by contamination from nearby features. We speculate on further implications of
stray light for interpretation of EUV images from TRACE and similar
instruments, and advocate deconvolution as a standard tool for image analysis
with future instruments such as SDO/AIA.Comment: Accepted by APJ; v2 reformatted to single-column format for online
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Limitations of adjustment for reporting tendency in observational studies of stress and self reported coronary heart disease
Recently, observational evidence has been suggested to show a causal association between various "psychosocial" exposures, including psychological stress, and heart disease. Much of this evidence derives from studies in which a self reported psychosocial exposure is related to an outcome dependent on the subjective experience of coronary heart disease (CHD) symptoms. Such outcomes may be measured using standard symptom questionnaires (like the Rose angina schedule). Alternatively they may use diagnoses of disease from medical records, which depend on an individual perceiving symptoms and reporting them to a health worker. In these situations, reporting bias may generate spurious exposure-outcome associations. For example if people who perceive and report their life as most stressful also over-report symptoms of cardiovascular disease then an artefactual association between stress and heart disease will result
Individual employment histories and subsequent cause specific hospital admissions and mortality: a prospective study of a cohort of male and female workers with 21 years follow up
It is a widely held view that the labour market is demanding increased levels of flexibility, and that this is causing greater psychosocial stress among employees.1 Such stress may affect health, either through neuroendocrine pathways, or through increases in behaviours linked with poor health.2 Previously we presented evidence linking an unstable employment history, as measured by a greater number of job changes and shorter duration of current job, with a greater prevalence of smoking and greater alcohol consumption, in male and female workers.3 4 Despite this, we did not observe clear detrimental effects of such instability on health related physiological measures (body mass index, diastolic blood pressure, cholesterol, and lung function), nor on current cardiovascular health (electrocardiogram determined ischaemia and reported symptoms of angina).
Finding work is easier for healthy persons, and those persons who need to find work repeatedly will be particularly likely to drop out of the workforce if their health deteriorates. Consequently, an occupational cohort, upon which our previous work was based, is least likely to include people of poor health with an unstable work history. If such people are underrepresented, attempts to determine the association between health and individual work histories will mislead. This study links the same cohort to information on the hospitalisations and deaths experienced over a 21 year follow up period. While those people whose health deteriorated before the enrolment of this cohort must remain poorly represented, these prospective data permit unbiased observation of those cases who experienced ill health subsequently, whether or not this resulted in an exit from the workforce. We hypothesise that an employment history characterised by frequent job changes, whatever the motivation for those changes, will require the person to be more focused on work, and less focused on maintaining personal health, with consequent poorer health for such people
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