22 research outputs found
Paths to wider adoption of e-infrastructure services
This paper presents work conducted as part of the e-Uptake project, which aims to widen the uptake of e-Infrastructure services for research. We will discuss our fieldwork conducted so far, give examples of the barriers and enablers identified and discuss how using the accumulated knowledge can lead to paving the way for wider adoption of e Infrastructure Services
Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry
We describe a new technique, high fdelity Imaging Retinal Densitometry (IRD), which probes the
functional integrity of the outer retinal complex. We demonstrate the ability of the technique to
map visual pigment optical density and synthesis rates in eyes with and without macular disease. A
multispectral retinal imaging device obtained precise measurements of retinal refectance over space
and time. Data obtained from healthy controls and 5 patients with intermediate AMD, before and after
photopigment bleaching, were used to quantify visual pigment metrics. Heat maps were plotted to
summarise the topography of rod and cone pigment kinetics and descriptive statistics conducted to
highlight diferences between those with and without AMD. Rod and cone visual pigment synthesis
rates in those with AMD (v=0.043SD 0.019minâ1 and v=0.119SD 0.046minâ1, respectively)
were approximately half those observed in healthy controls (v=0.079SD 0.024minâ1 for rods and
v=0.206SD 0.069minâ1 for cones). By mapping visual pigment kinetics across the central retina,
high fdelity IRD provides a unique insight into outer retinal complex function. This new technique
will improve the phenotypic characterisation, diagnosis and treatment monitoring of various ocular
pathologies, including AMD
Maternal psychological distress in primary care and association with child behavioural outcomes at age three
Observational studies indicate children whose mothers have poor mental health are at increased risk of socio-emotional behavioural difficulties, but it is unknown whether these outcomes vary by the mothersâ mental health recognition and treatment status. To examine this question, we analysed linked longitudinal primary care and research data from 1078 women enrolled in the Born in Bradford cohort. A latent class analysis of treatment status and self-reported distress broadly categorised women as (a) not having a common mental disorder (CMD) that persisted through pregnancy and the first 2 years after delivery (N = 756, 70.1 %), (b) treated for CMD (N = 67, 6.2 %), or (c) untreated (N = 255, 23.7 %). Compared to children of mothers without CMD, 3-year-old children with mothers classified as having untreated CMD had higher standardised factor scores on the Strengths and Difficulties Questionnaire (d = 0.32), as did children with mothers classified as having treated CMD (d = 0.27). Results were only slightly attenuated in adjusted analyses. Children of mothers with CMD may be at risk for socio-emotional and behavioural difficulties. The development of effective treatments for CMD needs to be balanced by greater attempts to identify and treat women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00787-015-0777-2) contains supplementary material, which is available to authorized users
Novel acoustic coupling bath using magnetite nanoparticles for MRâguided transcranial focused ultrasound surgery
Paths to wider adoption of e-Infrastructures services
This paper presents work conducted as part of the e-Uptake project, which aims to widen the uptake of e-Infrastructure services for research. We will discuss our fieldwork conducted so far, give examples of the barriers and enablers identified and discuss how using the accumulated knowledge can lead to paving the way for wider adoption of e Infrastructure Services
Paths to wider adoption of e-Infrastructures services
This paper presents work conducted as part of the e-Uptake project, which aims to widen the uptake of e-Infrastructure services for research. We will discuss our fieldwork conducted so far, give examples of the barriers and enablers identified and discuss how using the accumulated knowledge can lead to paving the way for wider adoption of e Infrastructure Services
Paths to wider adoption of e-infrastructure services
This paper presents work conducted as part of the e-Uptake project, which aims to widen the uptake of e-Infrastructure services for research. We will discuss our fieldwork conducted so far, give examples of the barriers and enablers identified and discuss how using the accumulated knowledge can lead to paving the way for wider adoption of e Infrastructure Services
Adoption of e-infrastructure services : inhibitors enablers and opportunities
Based on more than 100 interviews with respondents from the academic community and information services, we present findings from our study of inhibitors and enablers of adoption of e-Infrastructure services for research. We discuss issues raised and potential ways of addressing them