Domain Adaptation for Statistical Classifiers

The most basic assumption used in statistical learning theory is that training data and test data are drawn from the same underlying distribution. Unfortunately, in many applications, the "in-domain" test data is drawn from a distribution that is related, but not identical, to the "out-of-domain" distribution of the training data. We consider the common case in which labeled out-of-domain data is plentiful, but labeled in-domain data is scarce. We introduce a statistical formulation of this problem in terms of a simple mixture model and present an instantiation of this framework to maximum entropy classifiers and their linear chain counterparts. We present efficient inference algorithms for this special case based on the technique of conditional expectation maximization. Our experimental results show that our approach leads to improved performance on three real world tasks on four different data sets from the natural language processing domain

Verminderung von Alkaloiden in der Nahrungskette durch die züchterische Verbesserung der Mutterkorn-Resistenz von Winterroggen

Rye as an outcrossing crop is highly susceptible to ergot infection caused by Claviceps purpurea. It is ecologically the best solution to avoid the infection already in the field by growing resistant varieties. Aim of our study is the analysis of inheritance of self-fertile rye material for ergot resistance and alcaloid content. Sixty CMS inbred lines and their 90 CMS crosses were tested in pollen-isolated fields in three environ-ments under the conditions of Ecological Farming by artificial inoculation. The sclerotia weight per head was evaluated as resistance trait. Both, CMS lines and testcrosses showed significant genotypic differences at the individual environments. Correlation between both groups was significant (r=0,6-0,7; P=0,01). The alcaloid contents and the alcaloid spectra of 25 CMS lines revealed no genotypic difference. Breeding of self-fertile rye for a higher resistance to ergot should be successful on the long run

In vitro assembly and activity of an archaeal CRISPR-Cas type I-A Cascade interference complex.

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated (Cas) systems of type I use a Cas ribonucleoprotein complex for antiviral defense (Cascade) to mediate the targeting and degradation of foreign DNA. To address molecular features of the archaeal type I-A Cascade interference mechanism, we established the in vitro assembly of the Thermoproteus tenax Cascade from six recombinant Cas proteins, synthetic CRISPR RNAs (crRNAs) and target DNA fragments. RNA-Seq analyses revealed the processing pattern of crRNAs from seven T. tenax CRISPR arrays. Synthetic crRNA transcripts were matured by hammerhead ribozyme cleavage. The assembly of type I-A Cascade indicates that Cas3′ and Cas3′′ are an integral part of the complex, and the interference activity was shown to be dependent on the crRNA and the matching target DNA. The reconstituted Cascade was used to identify sequence motifs that are required for efficient DNA degradation and to investigate the role of the subunits Cas7 and Cas3′′ in the interplay with other Cascade subunits

Diabetes mellitus and oral lichen planus: A systematic review and meta-analysis

Objective: To undertake a meta-analysis of the association of Oral Lichen Planus (OLP) with diabetes, two diseases with an important impact on public health and the economy, but the evidence of which about their association is inconsistent. Methods: Relevant studies were localized by searching MEDLINE, EMBASE, Conference Proceedings, and other databases from inception to October 2020, without restrictions. The reference lists of included studies and of related reviews were also inspected. Global pooled odds ratios were calculated, and predefined subgroup analyses were performed. The heterogeneity between studies and publication bias was assessed and sensitivity analysis was carried out. Results: Thirty-two studies were included in the meta-analysis. Pooled ORs showed a moderate association between diabetes and OLP [OR: 1.87 (95%CI: 1.57, 2.34)]. The association is limited to studies carried out on adults only [OR: 2.12 (95%CI: 1.75, 2.57)] and is observed in all study designs. Globally, the heterogeneity was low to moderate. Studies carried out in European populations show a stronger association of diabetes and OLP than Asiatic studies [OR: 2.49 (95%CI: 1.87, 3.32) and 1.60 (95%CI: 1.25, 2.03), respectively]. Conclusions: Diabetes and OLP are moderately associated. Systematic diagnosis of diabetes in OLP patients could prove usefulS

Addressing vulnerability, building resilience:community-based adaptation to vector-borne diseases in the context of global change

Abstract Background The threat of a rapidly changing planet – of coupled social, environmental and climatic change – pose new conceptual and practical challenges in responding to vector-borne diseases. These include non-linear and uncertain spatial-temporal change dynamics associated with climate, animals, land, water, food, settlement, conflict, ecology and human socio-cultural, economic and political-institutional systems. To date, research efforts have been dominated by disease modeling, which has provided limited practical advice to policymakers and practitioners in developing policies and programmes on the ground. Main body In this paper, we provide an alternative biosocial perspective grounded in social science insights, drawing upon concepts of vulnerability, resilience, participation and community-based adaptation. Our analysis was informed by a realist review (provided in the Additional file 2) focused on seven major climate-sensitive vector-borne diseases: malaria, schistosomiasis, dengue, leishmaniasis, sleeping sickness, chagas disease, and rift valley fever. Here, we situate our analysis of existing community-based interventions within the context of global change processes and the wider social science literature. We identify and discuss best practices and conceptual principles that should guide future community-based efforts to mitigate human vulnerability to vector-borne diseases. We argue that more focused attention and investments are needed in meaningful public participation, appropriate technologies, the strengthening of health systems, sustainable development, wider institutional changes and attention to the social determinants of health, including the drivers of co-infection. Conclusion In order to respond effectively to uncertain future scenarios for vector-borne disease in a changing world, more attention needs to be given to building resilient and equitable systems in the present

Poly(para-phenyleneethynylene)s as emtters in polymer LEDs

11 different dialkoxy- and dialkyl-poly(para-phenyleneethynylene)s (PPEs) featuring novel branched and literature described linear and branched side chains were prepared using a Sonogashira coupling. The side chains were of different length and branching character. The degree of polymerization of the PPEs ranged from Pn = 44–343 with polydispersities ranging from 1.5–3.1. Fairly simple OLED-stacks with up to three layers (electron injection, emitter layer, and hole injection) were produced. Depending upon the PPEs’ structure and the stack architecture but particularly the thickness of the emitting PPE-layer, a large increase in brightness up to 2.2 � 103 cd m�2 was observed, a significant improvement over earlier reported values