142 research outputs found
Cello Repertoire and Performance Practice in Modena under Francesco II d’Este: Giuseppe Colombi, Giovanni Battista Vitali and Domenico Galli
Compared to the attention given to the development of string music in Modena, the development of string music in the nearby city of Bologna in the seventeenth century has always received more focus in musicology. However, the earliest composers who composed solo pieces for cello were instead primarily active in Modena. This study investigates the exchange and development of string music between Modena and Bologna in the mid to late seventeenth century under the leadership of Francesco II d'Este. A critical edition of three compositions for solo cello by Giuseppe Colombi, Giovanni Battista Vitali and Domenico Galli is presented with commentary on the historical background of the period
Zero-shot information extraction from radiological reports using ChatGPT
Electronic health records contain an enormous amount of valuable information,
but many are recorded in free text. Information extraction is the strategy to
transform the sequence of characters into structured data, which can be
employed for secondary analysis. However, the traditional information
extraction components, such as named entity recognition and relation
extraction, require annotated data to optimize the model parameters, which has
become one of the major bottlenecks in building information extraction systems.
With the large language models achieving good performances on various
downstream NLP tasks without parameter tuning, it becomes possible to use large
language models for zero-shot information extraction. In this study, we aim to
explore whether the most popular large language model, ChatGPT, can extract
useful information from the radiological reports. We first design the prompt
template for the interested information in the CT reports. Then, we generate
the prompts by combining the prompt template with the CT reports as the inputs
of ChatGPT to obtain the responses. A post-processing module is developed to
transform the responses into structured extraction results. We conducted the
experiments with 847 CT reports collected from Peking University Cancer
Hospital. The experimental results indicate that ChatGPT can achieve
competitive performances for some extraction tasks compared with the baseline
information extraction system, but some limitations need to be further
improved
Financial Time-Series Forecasting: Towards Synergizing Performance And Interpretability Within a Hybrid Machine Learning Approach
In the realm of cryptocurrency, the prediction of Bitcoin prices has garnered
substantial attention due to its potential impact on financial markets and
investment strategies. This paper propose a comparative study on hybrid machine
learning algorithms and leverage on enhancing model interpretability.
Specifically, linear regression(OLS, LASSO), long-short term memory(LSTM),
decision tree regressors are introduced. Through the grounded experiments, we
observe linear regressor achieves the best performance among candidate models.
For the interpretability, we carry out a systematic overview on the
preprocessing techniques of time-series statistics, including decomposition,
auto-correlational function, exponential triple forecasting, which aim to
excavate latent relations and complex patterns appeared in the financial
time-series forecasting. We believe this work may derive more attention and
inspire more researches in the realm of time-series analysis and its realistic
applications
Overprotection and overcontrol in childhood: An evaluation on reliability and validity of 33-item expanded Childhood Trauma Questionnaire (CTQ-33), Chinese version
Overprotection and overcontrol from parents or other family members, which are not rare in the Chinese culture, have been suggested to be traumatic experiences for some children. However, research on overprotection/overcontrol is much rarer in China compared with other childhood trauma subtypes. One of the possible reasons for this is the lack of easy and feasible screening tools. In this study, we therefore translated and validated a Chinese version of the 33-item Childhood Trauma Questionnaire (CTQ-33), which was expanded from the widely-used 28-item CTQ with an additional overprotection/overcontrol subscale. A total of 248 young healthy participants were recruited and completed the Chinese version of CTQ-33, and 50 of them were retested after an interval of two weeks. At baseline, all participants also completed the 9-item Patient Health Questionnaire and the 7-item Generalized Anxiety Disorder Scale to assess their depression and anxiety, respectively. Our main findings include that: (1) the Chinese version of CTQ-33 showed a good internal consistency (Cronbach\u27s α coefficient = 0.733) and an excellent test-retest reliability over a two-week period (ICC = 0.861); (2) the previously reported significant associations between the overprotection/overcontrol and other subtypes of childhood trauma (abuse and neglect), as well as psychopathological conditions such as depression can all be replicated using the Chinese version of CTQ-33. These results suggest that the Chinese version of CTQ-33 would be a promising tool for assessing various subtypes of childhood adversities, especially the overprotection/overcontrol experiences in Chinese populations
Efficacy and safety of chimeric antigen receptor T cell therapy in relapsed/refractory diffuse large B-cell lymphoma with different HBV status: a retrospective study from a single center
BackgroundChimeric antigen receptor T cell (CAR-T) therapy is an effective salvage treatment in relapsed or refractory(r/r) diffuse large B-cell lymphoma (DLBCL), but the impact of hepatitis B virus (HBV) infection has not been studied.Methods and resultsHere, 51 patients with r/r DLBCL receiving CAR-T therapy were enrolled and analyzed at the First Affiliated Hospital of Soochow University. The overall response rate and the complete remission rate (CR) of CAR-T therapy were 74.5% and 39.2%, respectively. With a median follow-up of 21.1 months after CAR-T, the probabilities of overall survival (OS) and progression-free survival (PFS) at 36 months were 43.4% and 28.7%, respectively. These patients were divided into three cohorts including chronic HBV infection group (n=6), resolved HBV infection group (n=25) and non-HBV infection group (n=20). Bone marrow involvement was significantly higher in the HBV infection group(P<0.001), other basic characteristics before CAR-T therapy were comparable. Subgroup analysis showed that HBV infection status did not affect the efficacy of CAR-T therapy in CR rate, OS or PFS, and there was no significant difference in CAR-T related toxicities between three cohorts. Only one cirrhosis patient with chronic HBV infection experienced HBV reactivation.ConclusionsCAR-T therapy was effective and can be used safely in r/r DLBCL with HBV infection under proper monitoring and antiviral prophylaxis
Conspecific cues that induce spore settlement in the biofouling and green tide-forming alga Ulva tepida provide a potential aggregation mechanism
Abstract(#br)Ulva, an important biofouling and green tide-forming alga, forms aggregations that have adverse economic and ecological impacts. However, little is known regarding the aggregation mechanism of Ulva . Knowledge of Ulva aggregation provides clues for controlling this alga in marine biofouling and green tides. We hypothesized Ulva contains conspecific settlement cue(s). Hexane and dichloromethane extracts of U. tepida fronds were found to induce the settlement of conspecific spores. From these extracts, two bioactive compounds that induce spore settlement in U. tepida were isolated: C16:4 at 5 μg mL −1 and di-n-butyl phthalate at 0.1–10 μg mL −1 . Fatty acids with different carbon chains (C 16 –C 18 ) and degrees of saturation, C16:1 and C18:2, previously reported to be present in U. tepida fronds, showed significant inducing activity for spore settlement. C16:1, C16:4, C18:2, and di-n-butyl phthalate all triggered dense settlements of U. tepida spores. The results support our hypothesis and provide insight into possible aggregation mechanisms for Ulva
Aggregation Pheromone for an Invasive Mussel Consists of a Precise Combination of Three Common Purines
Summary(#br)Most marine benthic invertebrates have a pelagic larval phase, after which they settle preferentially on or near conspecific adults, forming aggregations. Although settlement pheromones from conspecific adults have been implicated as critical drivers of aggregation for more than 30 years, surprisingly few have been unambiguously identified. Here we show that in the invasive dreissenid mussel Mytilopsis sallei (an ecological and economic pest), three common purines (adenosine, inosine, and hypoxanthine) released from adults in a synergistic and precise ratio (1:1.125:3.25) serve as an aggregation pheromone by inducing conspecific larval settlement and metamorphosis. Our results demonstrate that simple common metabolites can function as species-specific pheromones when present in precise combinations. This study provides important insights into our understanding of the ecology and communication processes of invasive organisms and indicates that the combination and ratio of purines might be critical for purine-based signaling systems that are fundamental and widespread in nature
Aggregation Pheromone for an Invasive Mussel Consists of a Precise Combination of Three Common Purines.
Most marine benthic invertebrates have a pelagic larval phase, after which they settle preferentially on or near conspecific adults, forming aggregations. Although settlement pheromones from conspecific adults have been implicated as critical drivers of aggregation for more than 30 years, surprisingly few have been unambiguously identified. Here we show that in the invasive dreissenid mussel Mytilopsis sallei (an ecological and economic pest), three common purines (adenosine, inosine, and hypoxanthine) released from adults in a synergistic and precise ratio (1:1.125:3.25) serve as an aggregation pheromone by inducing conspecific larval settlement and metamorphosis. Our results demonstrate that simple common metabolites can function as species-specific pheromones when present in precise combinations. This study provides important insights into our understanding of the ecology and communication processes of invasive organisms and indicates that the combination and ratio of purines might be critical for purine-based signaling systems that are fundamental and widespread in nature
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