Antibodies to myofibril antigens in cosmonauts after spaceflights

Serum samples obtained from 15 astronauts before and after spaceflights were studied with the use of the indirect immunofluorescent method. In seven astronauts antibodies to different elements of the human heart muscle appeared after flights. Strong and very strong luminescence of the elements of heart muscle tissue was detected in the astronauts after the third space flight. In a study of the sera on sections of bovine heart muscle tissue the reactions of the sera taken before and after flight were found to show no essential differences

NEW DATA ON AGE AND NATURE OF CARBONIZATION WITHIN SOUTHERN FLANK OF THE BAIKAL LEDGE OF THE SIBERIAN CRATON BASEMENT

The Baikal ledge rock formations in the Siberian craton structure are included in the Akitkan mobile belt which is considered as the Late Paleoproterozoic independent island arc system moved up to the ancient basement during the terrains amalgamation 1.91–2.00 Ga ago (Fig. 1) [Rosen, 2003; Gladkochub et al., 2009; Didenko et al., 2013].The Baikal ledge rock formations in the Siberian craton structure are included in the Akitkan mobile belt which is considered as the Late Paleoproterozoic independent island arc system moved up to the ancient basement during the terrains amalgamation 1.91–2.00 Ga ago (Fig. 1) [Rosen, 2003; Gladkochub et al., 2009; Didenko et al., 2013]

Russian sport economy: challenges and contradictions

The article shows that development of sport tends to be a factor of country competitiveness. Nowadays, there is a need to find new forms and methods of promotion and popularization of physical culture and sport, to create a single sports information space and to provide sports area with more effective management decisions. There were revealed the main challenges in sports area such as the difference of sports facilities in various regions of Russia, the creation of low-budget sports facilities, the development of qualitative modern material and technical base in educational institutions and another issue is qualified personnel training. Methods of achievement of the goals of strategy 2020 are also illustrated in the paper, that is getting large and medium-sized business involved in construction and operation of sports facilities as social one, creation of a single sports information space in order to control the workload of all the sports venues despite the fact of department affiliation

Development of the Republic of Sakha (Yakutia)'s Shadow Economy Assessment Methodology

The purpose of the article is to study the shadow economy assessment methodology. This article presents a comprehensive study of the parameters of a shadow economy, considers its essence, and defines its terminology. This study outlines the historical approach to the development of the shadow economy, both in Russia and worldwide, and gives a brief analysis of the economy of the Republic of Sakha. The authors examined the specifics of the statistical methods applied in assessing various structural elements of a shadow economy and measured and assessed the shadow economy in this region. The research conducted enabled the authors to formulate the main measures required to reduce the shadow economy. The scientific novelty is justified by the research results, which included studying and summarizing a wide range of published and unpublished materials, the examination of the initial and transitional periods of the shadow economy development in Yakutia. The article reveals the main causes and conditions that lead to the formation of the shadow economy in various sectors of the Yakutia economy. The solutions and suggestions proposed in the article are aimed at reducing the shadow economy parameters. The scientific research results are of theoretical and applied importance for public administration and authorities to improve the effectiveness of the fight against the shadow economy manifestations

Influence of hadronic interaction models and the cosmic ray spectrum on the high energy atmospheric muon and neutrino flux

The recent observations of muon charge ratio up to about 10 TeV and of atmospheric neutrinos up to energies of about 400 TeV has triggered a renewed interest into the high-energy interaction models and cosmic ray primary composition. A reviewed calculation of lepton spectra produced in cosmic-ray induced extensive air showers is carried out with a primary cosmic-ray spectrum that fits the latest direct measurements below the knee. In order to achieve this, we used a full Monte Carlo method to derive the inclusive differential spectra (yields) of muons, muon neutrinos and electron neutrinos at the surface for energies between 80 GeV and hundreds of PeV. The air shower simulator {\sc corsika} 6.990 was used for showering and propagation of the secondary particles through the atmosphere, employing the established high-energy hadronic interaction models {\sc sibyll} 2.1, {\sc qgsjet-01} and {\sc qgsjet-ii 03}. We show that the performance of the interaction models allows makes it possible to predict the spectra within experimental uncertainties, while {\sc sibyll} generally yields a higher flux at the surface than the qgsjet models. The calculation of the flavor and charge ratios has lead to inconsistent results, mainly influenced by the different representations of the K/$\pi$ ratio within the models. Furthermore, we could quantify systematic uncertainties of atmospheric muon- and neutrino fluxes, associated to the models of the primary cosmic-ray spectrum and the interaction models. For most recent parametrizations of the cosmic-ray primary spectrum, atmospheric muons can be determined with an uncertainty smaller than $^{+15}_{-13}$% of the average flux. Uncertainties of the muon- and electron neutrino fluxes can be calculated within an average error of $^{+32}_{-22}$% and $^{+25}_{-19}$%, respectively.Comment: 16 pages, 10 figures, version 2 includes analytic approximatio

Эффективность применения сторителлинга на уроках английского языка

Статья посвящена сторителлингу как одной из педагогических технологий. Рассказывание историй в образовательных целях является неотъемлемой частью человеческого общения с момента его появления. Однако эффективность данной технологии не всегда оценивается педагогами по достоинству. В данной статье раскрывается суть понятия сторителлинг, представлена связь между обучением и сторителлингом; дается объяснение, почему рассказывание историй работает как педагогическая технология. Представлены предложения и рекомендации по реализации сторителлинга как педагогической технологии.The article focuses on storytelling as one of the pedagogical technologies. Educational storytelling has been an integral part of human communication since its inception. However, the effectiveness of this technique is not always appreciated by teachers. This article explains the concept of storytelling, introduces the relationship between learning and storytelling and shows why storytelling works as a pedagogical technology. There are also suggestions and recommendations for the implementation of storytelling as a pedagogical technology

Some clinical and diagnostic features of patients with new-onset epilepsy in the presence of chronic cerebrovascular disease

Objective: to investigate the specific features of epilepsy that manifests itself in the presence of chronic cerebrovascular disease.Patients and methods. A total of 304 patients (a study group of 174 patients with new-onset seizures developing in the presence of cerebrovascular disease and a control group of 130 patients with cerebrovascular disease and no seizures) were examined. They underwent clinical neurological examination, electroencephalography (EEG), ultrasonic duplex scanning of extra- and intracranial arteries with functional tests, and visualization of brain structures.Results. Focal seizures were prevalent in the patients with cerebrovascular disease and epilepsy. It was found that there was a preponderance of left-sided localization of EEG foci of abnormal activity and a tendency to more commonly detect subcritical and critical stenoses in the left carotid bed in the patients with epileptic seizures. Diminished perfusion reserves in the posterior circulation system were more frequently observed in the patients with seizures in the presence of cardiovascular diseases. Moreover, the patients with seizures displayed a more profound degree of brain ischemia with the frequent cortical and subcortical localization of dyscirculatory foci. Thus, a study of perfusion reserves, localization of vascular foci, and degree of occlusive changes in the wall of brachiocephalic vessels allows identification of risk factors for epilepsy in the patients with cerebrovascular disease and promotes the prediction of the course of the disease

High energy hadrons in EAS at mountain altitude

An extensive simulation has been carried out to estimate the physical interpretation of dynamical factors such as , in terms of high energy interaction features, concentrated in the present analysis on the average transverse momentum. It appears that the large enhancement observed for versus primary energy, suggesting in earliest analysis a significant rise of with energy, is only the result of the limited resolution of the detectors and remains in agreement with a wide range of models used in simulations.Comment: 13 pages, 6 PostScript figures, LaTeX Subm. to JPhys

Effects of 1,3,4-thiadiazine compound with antidepressant properties in ligation model of acute pancreatitis

Based on hypotheses concerning the role of stress in acute pancreatitis development, the experimental approach for the decrease stress damage via the use the compound with proven antistress/neuroleptic action was conducted. The study was aimed to discover 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (compound L-17) therapeutic action in experimental acute pancreatitis. The experimental model used was the ligation model. The trial was carried out on 50 male Wistar rats with average body weight 180-240g. Histological picture of the pancreas was studied and biochemical and enzyme-immunoassays were carried out on the first and seventh days. The significant reduction in mortality on the background of L-17 compound administration was observed. While levels of all cytokines increased in induced experimental acute pancreatitis groups, the cytokine level rise was decreased when compound L-17 was administered. On the cellular level, the study revealed L-17’s ability to prevent granulocytosis and decrease granulocytes infiltration to inflammatory foci. The decrease in inflammatory reaction magnitude and prevention of abscess formation in experimental acute pancreatitis accompanied by sistemic inflamamtion was due to L-17’s ability to reduce neutrophilia and neutrophil entry into the injury zone. © 2018, Slovak Academy of Sciences. All rights reserved.Government Council on Grants, Russian FederationMinistry of Education and Science of the Russian Federation, Minobrnauka: 17.7255.2017/8.9AAAA-A18-118020690020-1Funding information. Partly the study was supported by the Act 211 of the Government of Russian Federation, contract No 02.A03.21.0006; Government contract of Russian Federation with Institute of Immunology and Physiology (AAAA-A18-118020690020-1) and the Ministry of Education and Science of the Russian Federation (# 17.7255.2017/8.9)

Local pedagogical history in training bachelors of education

The main aim of the study is to investigate the issues of pedagogy and technology of local history studies applied in training Bachelors of Education at a pedagogical University. The authors describe results of experimental work carried out at Stary Oskol branch of Belgorod State National Research University and approbation of local pedagogical history technology. Regarding the methods used in the study, we consider the training system containing local history concepts is made up by the following components: the training process, educational activities and research, teacher’s internship, extracurricular and outreach activitie