“Bond of love”: The action of the spirit

The emergence of the various forms of Pentecostal and Charismatic theology has led to a welcome interest in the third Person of the Trinity, who has been largely neglected for centuries. However, while there has been a concentration on the experience of the Spirit, this has not been matched by an understanding of his work. The ancient idea, seen especially in Augustine, is that the main activity of the Spirit is that of providing relationship, as the “bond of love”; this provides a key concept which undergirds the work of the Spirit in creation, redemption, sanctification and empowering. It is hoped that increased understanding of the work of the Spirit will contribute to the healing of divisions in Christianity which emerged out of conflictingattitudes to the modern experiences

Stability of the fragments and thermalization at peak center-of-mass energy

We simulate the central reactions of nearly symmetric, and asymmetric systems, for the energies at which the maximum production of IMFs occurs (E$_{c.m.}^{peak}$).This study is carried out by using hard EOS along with cugnon cross section and employing MSTB method for clusterization. We study the various properties of fragments. The stability of fragments is checked through persistence coefficient and gain term. The information about the thermalization and stopping in heavy-ion collisions is obtained via relative momentum, anisotropy ratio, and rapidity distribution. We find that for a complete stopping of incoming nuclei very heavy systems are required. The mass dependence of various quantities (such as average and maximum central density, collision dynamics as well as the time zone for hot and dense nuclear matter) is also presented. In all cases (i.e., average and maximum central density, collision dynamics as well as the time zone for hot and dense nuclear matter) a power law dependence is obtained.Comment: 21 Pages, 8 Figure

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

Eosinophil accumulation is a prominent feature of allergic inflammatory reactions, such as those occurring in the lung of the allergic asthmatic, but the endogenous chemoattractants involved have not been identified. We have investigated this in an established model of allergic inflammation, using in vivo systems both to generate and assay relevant activity. Bronchoalveolar lavage (BAL) fluid was taken from sensitized guinea pigs at intervals after aerosol challenge with ovalbumin. BAL fluid was injected intradermally in unsensitized assay guinea pigs and the accumulation of intravenously injected 111In-eosinophils was measured. Activity was detected at 30 min after allergen challenge, peaking from 3 to 6 h and declining to low levels by 24 h. 3-h BAL fluid was purified using high performance liquid chromatography techniques in conjunction with the skin assay. Microsequencing revealed a novel protein from the C-C branch of the platelet factor 4 superfamily of chemotactic cytokines. The protein, eotaxin, exhibits homology of 53% with human MCP-1, 44% with guinea pig MCP-1, 31% with human MIP-1α, and 26% with human RANTES. Laser desorption time of flight mass analysis gave four different signals (8.15, 8.38, 8.81, and 9.03 kD), probably reflecting differential O-glycosylation. Eotaxin was highly potent, inducing substantial 111In-eosinophil accumulation at a 1-2-pmol dose in the skin, but did not induce significant 111In-neutrophil accumulation. Eotaxin was a potent stimulator of both guinea pig and human eosinophils in vitro. Human recombinant RANTES, MIP-1α, and MCP-1 were all inactive in inducing 111In-eosinophil accumulation in guinea pig skin; however, evidence was obtained that eotaxin shares a binding site with RANTES on guinea pig eosinophils. This is the first description of a potent eosinophil chemoattractant cytokine generated in vivo and suggests the possibility that similar molecules may be important in the human asthmatic lung

Judgement utility modulates the use of explicit contextual priors and visual information during anticipation

Objectives: We examined the impact of judgement utility on the use of explicit contextual priors and visual information during action anticipation in soccer. Design: We employed a repeated measures design, in which expert soccer players had to perform a video-based anticipation task under various conditions. Methods: The task required the players to predict the direction (left or right) of an oncoming opponent’s imminent actions. Performance and verbal reports of thoughts from players were compared across three conditions. In two of the conditions, contextual priors pertaining to the opponent’s action tendencies (dribble = 70%; pass = 30%) were explicitly provided. In one of these experimental conditions, players were told that an incorrect ‘right’ response would result in conceding a goal, which created imbalanced judgement utility (left = high utility; right = low utility). In the third control condition, no explicit contextual priors or additional instructions were provided. Results: The explicit provision of contextual priors changed players’ processing priorities, biased their anticipatory judgements in accordance with the opponent’s action tendencies, and enhanced anticipation performance. These effects were suppressed under conditions in which the explicit contextual priors were accompanied by imbalanced judgement utility. Under these conditions, the players were more concerned about the consequences of their judgements and were more inclined to opt for the direction with the higher utility. Conclusions: It appears that judgement utility disrupts the integration of contextual priors and visual information, which results in decreased impact of explicit contextual priors during action anticipation

The use of contextual priors and visual information during anticipation in sport: Toward a Bayesian integration framework

© 2020 The Author(s). Expert performance across a range of domains is underpinned by superior perceptual-cognitive skills. Over the last five decades, researchers have provided evidence that experts can identify and interpret opponent kinematics more effectively than their less experienced counterparts. More recently, researchers have demonstrated that experts also use non-kinematic information, in this paper termed contextual priors, to inform their predictive judgments. While the body of literature in this area continues to grow exponentially, researchers have yet to develop an overarching theoretical framework that can predict and explain anticipatory behaviour and provide empirically testable hypotheses to guide future work. In this paper, we propose that researchers interested in anticipation in sport could adopt a Bayesian model for probabilistic inference as an overarching framework. We argue that athletes employ Bayesian reliability-based strategies in order to integrate contextual priors with evolving kinematic information during anticipation. We offer an insight into Bayesian theory and demonstrate how contemporary literature in sport psychology fits within this framework. We hope that the paper encourages researchers to engage with the Bayesian literature in order to provide greater insight into expert athletes’ assimilation of various sources of information when anticipating the actions of others in complex and dynamic environments

Integrating explicit contextual priors and kinematic information during anticipation

© 2020 The Author(s). We examined the interaction between explicit contextual priors and kinematic information during anticipation in soccer. We employed a video-based anticipation task where skilled soccer players had to predict the direction of the imminent actions of an attacking opponent in possession of the ball. The players performed the task both with and without explicit contextual priors pertaining to the opponent’s action tendencies. The strength of the opponent’s action tendencies was altered in order to manipulate the reliability of contextual priors (low vs. high). Moreover, the reliability of kinematic information (low vs. high) was manipulated using the temporal occlusion paradigm. The explicit provision of contextual priors biased anticipation towards the most likely direction, given the opponent’s action tendencies, and resulted in enhanced performance. This effect was greater under conditions where the reliability of kinematic information was low rather than high. When the reliability of kinematic information was high, the players used explicit contextual priors of high, but not low, reliability to inform their judgements. Findings suggest that athletes employ reliability-based strategies when integrating contextual priors with kinematic information during anticipation. The impact of explicit contextual priors is dependent on the reliability both of the priors and the evolving kinematic information

Issues potentially affecting quality of life arising from long-term medicines use: a qualitative study

Background Polypharmacy is increasing and managing large number of medicines may create a burden for patients. Many patients have negative views of medicines and their use can adversely affect quality of life. No studies have specifically explored the impact of general long-term medicines use on quality of life. Objective To determine the issues which patients taking long-term medicines consider affect their day-to-day lives, including quality of life. Setting Four primary care general practices in North West England Methods Face-to-face interviews with adults living at home, prescribed four or more regular medicines for at least 1 year. Interviewees were identified from primary care medical records and purposively selected to ensure different types of medicines use. Interviews were recorded, transcribed and analysed thematically. Results Twenty-one interviews were conducted and analysed. Patients used an average of 7.8 medicines, 51 % were preventive, 40 % for symptom relief and 9 % treatment. Eight themes emerged: relationships with health professionals, practicalities, information, efficacy, side effects, attitudes, impact and control. Ability to discuss medicines with health professionals varied and many views were coloured by negative experiences, mainly with doctors. All interviewees had developed routines for using multiple medicines, some requiring considerable effort. Few felt able to exert control over medicines routines specified by health professionals. Over half sought additional information about medicines whereas others avoided this, trusting in doctors to guide their medicines use. Patients recognised their inability to assess efficacy for many medicines, notably those used for prophylaxis. All were concerned about possible side effects and some had poor experiences of discussing concerns with doctors. Medicines led to restrictions on social activities and personal life to the extent that, for some, life can revolve around medicines. Conclusion There is a multiplicity and complexity of issues surrounding medicines use, which impact on day-to-day lives for patients with long-term conditions. While most patients adapt to long-term medicines use, others did so at some cost to their quality of life

The distribution of pond snail communities across a landscape: separating out the influence of spatial position from local habitat quality for ponds in south-east Northumberland, UK

Ponds support a rich biodiversity because the heterogeneity of individual ponds creates, at the landscape scale, a diversity of habitats for wildlife. The distribution of pond animals and plants will be influenced by both the local conditions within a pond and the spatial distribution of ponds across the landscape. Separating out the local from the spatial is difficult because the two are often linked. Pond snails are likely to be affected by both local conditions, e.g. water hardness, and spatial patterns, e.g. distance between ponds, but studies of snail communities struggle distinguishing between the two. In this study, communities of snails were recorded from 52 ponds in a biogeographically coherent landscape in north-east England. The distribution of snail communities was compared to local environments characterised by the macrophyte communities within each pond and to the spatial pattern of ponds throughout the landscape. Mantel tests were used to partial out the local versus the landscape respective influences. Snail communities became more similar in ponds that were closer together and in ponds with similar macrophyte communities as both the local and the landscape scale were important for this group of animals. Data were collected from several types of ponds, including those created on nature reserves specifically for wildlife, old field ponds (at least 150 years old) primarily created for watering livestock and subsidence ponds outside protected areas or amongst coastal dunes. No one pond type supported all the species. Larger, deeper ponds on nature reserves had the highest numbers of species within individual ponds but shallow, temporary sites on farm land supported a distinct temporary water fauna. The conservation of pond snails in this region requires a diversity of pond types rather than one idealised type and ponds scattered throughout the area at a variety of sites, not just concentrated on nature reserves