Fish-hook injuries: a risk for fishermen

Fishing is one of the best known and practiced human activities. However, you should remember that, when casting the hook from the riverbank or grasping it to add bait, fishermen run a real risk of injury if the hook punctures the skin

The Distribution of Dengue Virus Serotype in Quang Nam Province (Vietnam) during the Outbreak in 2018

Objectives: Quang Nam province in the Centre of Vietnam has faced an outbreak of dengue hemorrhagic fever (DHF) in 2018. Although DHF is a recurrent disease in this area, no epidemiological and microbiological reports on dengue virus serotypes have been conducted mainly due to lack of facilities for such a kind of advanced surveillance. The aim of this study was to detect different dengue virus serotypes in patients’ blood samples. Design and Methods: Suspected cases living in Quang Nam province (Vietnam) and presenting clinical and hematological signs of dengue hemorrhagic fever were included in the study. The screening was performed, and the results were compared by using two methodologies: RT real-time PCR (RT-rPCR) and the Dengue NS1 rapid test. Results: From December 2018 to February 2019, looking both at RT-rPCR [+] and NS1 [+] methodologies, a total of 488 patients were screened and 336 were positive for dengue virus detection (74 children and 262 adults); 273 of these patients (81.3%) underwent viral serotype identification as follows: 12.82% (35/273) D1 serotype, 17.95% (49/273) D2, 0.37% (1/273) D3, 68.50 (187/283) D4, and 0.37% (1/273) D2+D4 serotypes. The RT-rPCR outcomes showed higher sensitivity during the first three days of infection compared to NS1 (92.3% vs. 89.7%). The NS1 increased sensitivity after the first 3 days whilst the RT-rPCR decreased. Conclusions: Advanced surveillance with dengue virus serotypes identification, if performed routinely, may help to predict and prevent further DHF epidemics based on the exposure of the different serotypes during different periods that lead to the intensification of disease severity as a consequence of antibody-dependent enhancement (ADE)

KM3NeT broadcast optical data transport system

The optical data transport system of the KM3NeT neutrino telescope at the bottom of the Mediterranean Sea will provide more than 6000 optical modules in the detector arrays with a point-to-point optical connection to the control stations onshore. The ARCA and ORCA detectors of KM3NeT are being installed at a depth of about 3500 m and 2500 m, respectively and their distance to the control stations is about 100 kilometers and 40 kilometers. In particular, the two detectors are optimised for the detection of cosmic neutrinos with energies above about 1 TeV (ARCA) and for the detection of atmospheric neutrinos with energies in the range 1 GeV-1 TeV (ORCA). The expected maximum data rate is 200 Mbps per optical module. The implemented optical data transport system matches the layouts of the networks of electro-optical cables and junction boxes in the deep sea. For efficient use of the fibres in the system the technology of Dense Wavelength Division Multiplexing is applied. The performance of the optical system in terms of measured bit error rates, optical budget are presented. The next steps in the implementation of the system are also discussed

Green fabrication of stable lead-free bismuth based perovskite solar cells using a non-toxic solvent

The very fast evolution in certified efficiency of lead-halide organic-inorganic perovskite solar cells to 24.2%, on par and even surpassing the record for polycrystalline silicon solar cells (22.3%), bears the promise of a new era in photovoltaics and revitalisation of thin film solar cell technologies. However, the presence of toxic lead and particularly toxic solvents during the fabrication process makes large-scale manufacturing of perovskite solar cells challenging due to legislation and environment issues. For lead-free alternatives, non-toxic tin, antimony and bismuth based solar cells still rely on up-scalable fabrication processes that employ toxic solvents. Here we employ non-toxic methyl-acetate solution processed (CH3NH3)3Bi2I9 films to fabricate lead-free, bismuth based (CH3NH3)3Bi2I9 perovskites on mesoporous TiO2 architecture using a sustainable route. Optoelectronic characterization, X-ray diffraction and electron microscopy show that the route can provide homogeneous and good quality (CH3NH3)3Bi2I9 films. Fine-tuning the perovskite/hole transport layer interface by the use of conventional 2,2′,7,7′-tetrakis (N,N′-di-p-methoxyphenylamino)−9,9′-spirbiuorene, known as Spiro-OMeTAD, and poly(3-hexylthiophene-2,5-diyl - P3HT as hole transporting materials, yields power conversion efficiencies of 1.12% and 1.62% under 1 sun illumination. Devices prepared using poly(3-hexylthiophene-2,5-diyl hole transport layer shown 300 h of stability under continuous 1 sun illumination, without the use of an ultra violet-filter

The impact of microbiome dysbiosis on T cell function within the tumor microenvironment (TME)

Insights into the effect of the microbiome’s composition on immune cell function have recently been discerned and further characterized. Microbiome dysbiosis can result in functional alterations across immune cells, including those required for innate and adaptive immune responses to malignancies and immunotherapy treatment. Dysbiosis can yield changes in or elimination of metabolite secretions, such as short-chain fatty acids (SCFAs), from certain bacterial species that are believed to impact proper immune cell function. Such alterations within the tumor microenvironment (TME) can significantly affect T cell function and survival necessary for eliminating cancerous cells. Understanding these effects is essential to improve the immune system’s ability to fight malignancies and the subsequent efficacy of immunotherapies that rely on T cells. In this review, we assess typical T cell response to malignancies, classify the known impact of the microbiome and particular metabolites on T cells, discuss how dysbiosis can affect their function in the TME then further describe the impact of the microbiome on T cell-based immunotherapy treatment, with an emphasis on recent developments in the field. Understanding the impact of dysbiosis on T cell function within the TME can carry substantial implications for the design of immunotherapy treatments and further our understanding of factors that could impact how the immune system combats malignancies