1,207 research outputs found
Extreme Energy Cosmic Rays (EECR) Observation Capabilities of an "Airwatch from Space'' Mission
The longitudinal development and other characteristics of the EECR induced
atmospheric showers can be studied from space by detecting the fluorescence
light induced in the atmospheric nitrogen. According to the Airwatch concept a
single fast detector can be used for measuring both intensity and time
development of the streak of fluorescence light produced by the atmospheric
shower induced by an EECR. In the present communication the detection
capabilities for the EECR observation from space are discussed.Comment: 3 pages (LaTeX). To appear in the Proceedings of TAUP'9
Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice
Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice. In this study, we have investigated whether a similar increase of OX-A release occurs to the ventral tegmental area (VTA), an orexinergic LH output area with functional effects on dopaminergic signaling at the mesolimbic circuit. By confocal and correlative light and electron microscopy (CLEM) morphological studies coupled to molecular, biochemical, and pharmacological approaches, we investigated OX-A-mediated dopaminergic signaling at the LH-VTA-nucleus accumbens (NAc) pathway in obese ob/ob mice compared to wild-type (wt) lean littermates. We found an elevation of OX-A trafficking and release to the VTA of ob/ob mice and consequent orexin receptor-1 (OX1R)-mediated over-activation of dopaminergic (DA) neurons via phospholipase C (PLC)/diacylglycerol lipase (DAGL-α)-induced biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). In fact, by retrograde signaling to cannabinoid receptor type 1 (CB1R) at inhibitory inputs to DA neurons, 2-AG inhibited GABA release thus inducing an increase in DA concentration in the VTA and NAc of ob/ob mice. This effect was prevented by the OX1R antagonist SB-334867 (30 mg/Kg, i.p.), or the CB1R antagonist AM251 (10 mg/Kg, i.p.) and mimicked by OX-A injection (40 μg/Kg, i.p.) in wt lean mice. Enhanced DA signaling to the NAc in ob/ob mice, or in OX-A-injected wt mice, was accompanied by β-arrestin2-mediated desensitization of dopamine D2 receptor (D2R) in a manner prevented by SB-334867 or the D2R antagonist L741 (1.5 mg/Kg, i.p.). These results further support the role of OX-A signaling in the control of neuroadaptive responses, such as compulsive reward-seeking behavior or binge-like consumption of high palatable food, and suggest that aberrant OX-A trafficking to the DA neurons in the VTA of ob/ob mice influences the D2R response at NAc, a main target area of the mesolimbic pathway, via 2-AG/CB1-mediated retrograde signaling
The Cosmic-Ray Proton and Helium Spectra measured with the CAPRICE98 balloon experiment
A new measurement of the primary cosmic-ray proton and helium fluxes from 3
to 350 GeV was carried out by the balloon-borne CAPRICE experiment in 1998.
This experimental setup combines different detector techniques and has
excellent particle discrimination capabilities allowing clear particle
identification. Our experiment has the capability to determine accurately
detector selection efficiencies and systematic errors associated with them.
Furthermore, it can check for the first time the energy determined by the
magnet spectrometer by using the Cherenkov angle measured by the RICH detector
well above 20 GeV/n. The analysis of the primary proton and helium components
is described here and the results are compared with other recent measurements
using other magnet spectrometers. The observed energy spectra at the top of the
atmosphere can be represented by (1.27+-0.09)x10^4 E^(-2.75+-0.02) particles
(m^2 GeV sr s)^-1, where E is the kinetic energy, for protons between 20 and
350 GeV and (4.8+-0.8)x10^2 E^(-2.67+-0.06) particles (m^2 GeV nucleon^-1 sr
s)^-1, where E is the kinetic energy per nucleon, for helium nuclei between 15
and 150 GeV nucleon^-1.Comment: To be published on Astroparticle Physics (44 pages, 13 figures, 5
tables
Examination of direct-photon and pion production in proton-nucleon collisions
We present a study of inclusive direct-photon and pion production in hadronic
interactions, focusing on a comparison of the ratio of gamma/pi0 yields with
expectations from next-to-leading order perturbative QCD (NLO pQCD). We also
examine the impact of a phenomenological model involving k_T smearing (which
approximates effects of additional soft-gluon emission) on absolute predictions
for photon and pion production and their ratio.Comment: 20 pages, 12 figures. Minor changes in wording and in figure
Balloon Measurements of Cosmic Ray Muon Spectra in the Atmosphere along with those of Primary Protons and Helium Nuclei over Mid-Latitude
We report here the measurements of the energy spectra of atmospheric muons
and of the cosmic ray primary proton and helium nuclei in a single experiment.
These were carried out using the MASS superconducting spectrometer in a balloon
flight experiment in 1991. The relevance of these results to the atmospheric
neutrino anomaly is emphasized. In particular, this approach allows
uncertainties caused by the level of solar modulation, the geomagnetic cut-off
of the primaries and possible experimental systematics to be decoupled in the
comparison of calculated fluxes of muons to measured muon fluxes. The muon
observations cover the momentum and depth ranges of 0.3-40 GeV/c and 5-886
g/cmsquared, respectively. The proton and helium primary measurements cover the
rigidity range from 3 to 100 GV, in which both the solar modulation and the
geomagnetic cut-off affect the energy spectra at low energies.Comment: 31 pages, including 17 figures, simplified apparatus figure, to
appear in Phys. Rev.
Launch of the Space experiment PAMELA
PAMELA is a satellite borne experiment designed to study with great accuracy
cosmic rays of galactic, solar, and trapped nature in a wide energy range
protons: 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study
of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50
MeV-270 GeV) and search for antimatter with a precision of the order of 10^-8).
The experiment, housed on board the Russian Resurs-DK1 satellite, was launched
on June, 15, 2006 in a 350*600 km orbit with an inclination of 70 degrees. The
detector is composed of a series of scintillator counters arranged at the
extremities of a permanent magnet spectrometer to provide charge,
Time-of-Flight and rigidity information. Lepton/hadron identification is
performed by a Silicon-Tungsten calorimeter and a Neutron detector placed at
the bottom of the device. An Anticounter system is used offline to reject false
triggers coming from the satellite. In self-trigger mode the Calorimeter, the
neutron detector and a shower tail catcher are capable of an independent
measure of the lepton component up to 2 TeV. In this work we describe the
experiment, its scientific objectives and the performance in the first months
after launch.Comment: Accepted for publication on Advances in Space Researc
Measurement of the flux of atmospheric muons with the CAPRICE94 apparatus
A new measurement of the momentum spectra of both positive and negative muons
as function of atmospheric depth was made by the balloon-borne experiment
CAPRICE94. The data were collected during ground runs in Lynn Lake on the
19-20th of July 1994 and during the balloon flight on the 8-9th of August 1994.
We present results that cover the momentum intervals 0.3-40 GeV/c for negative
muons and 0.3-2 GeV/c for positive muons, for atmospheric depths from 3.3 to
1000 g/cm**2, respectively. Good agreement is found with previous measurements
for high momenta, while at momenta below 1 GeV/c we find latitude dependent
geomagnetic effects. These measurements are important cross-checks for the
simulations carried out to calculate the atmospheric neutrino fluxes and to
understand the observed atmospheric neutrino anomaly.Comment: 28 pages, 13 Postscript figures, uses revtex.sty, to appear in Phys.
Rev.
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