The pecularities of shear crack pre-rupture evolution and distribution of seismicity before strong earthquakes

Several methods are presently suggested for investigating pre-earthquake evolution of the regions of high tectonic activity based on analysis of the seismicity spatial distribution. Some precursor signatures are detected before strong earthquakes: decrease in fractal dimension of the continuum of earthquake epicenters, cluster formation, concentration of seismic events near one of the nodal planes of the future earthquake, and others. In the present paper, it is shown that such peculiarities are typical of the evolution of the shear crack network under external stresses in elastic bodies with inhomogeneous distribution of strength. The results of computer modeling of crack network evolution are presented. It is shown that variations of the fractal dimension of the earthquake epicenters’ continuum and other precursor signatures contain information about the evolution of the destruction process towards the main rupture

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study

Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep. The release of endogenous adenosine during the sleep-wake cycle has mainly been studied in vivo with microdialysis techniques. The biochemical changes that accompany sleep-wake status may be preserved in vitro. We have therefore used adenosine-sensitive biosensors in slices of the basal forebrain (BFB) to study both depolarization-evoked adenosine release and the steady state adenosine tone in rats, mice and hamsters. Adenosine release was evoked by high K+, AMPA, NMDA and mGlu receptor agonists, but not by other transmitters associated with wakefulness such as orexin, histamine or neurotensin. Evoked and basal adenosine release in the BFB in vitro exhibited three key features: the magnitude of each varied systematically with the diurnal time at which the animal was sacrificed; sleep deprivation prior to sacrifice greatly increased both evoked adenosine release and the basal tone; and the enhancement of evoked adenosine release and basal tone resulting from sleep deprivation was reversed by the inducible nitric oxide synthase (iNOS) inhibitor, 1400 W. These data indicate that characteristics of adenosine release recorded in the BFB in vitro reflect those that have been linked in vivo to the homeostatic control of sleep. Our results provide methodologically independent support for a key role for induction of iNOS as a trigger for enhanced adenosine release following sleep deprivation and suggest that this induction may constitute a biochemical memory of this state

Dynamics of multifractal and correlation characteristics of the spatio-temporal distribution of regional seismicity before the strong earthquakes

International audienceInvestigations of the distribution of regional seismicity and the results of numerical simulations of the seismic process show the increase of inhomogenity in spatio-temporal distribution of the seismicity prior to large earthquakes and formation of inhomogeneous clusters in a wide range of scales. Since that, the multifractal approach is appropriate to investigate the details of such dynamics. Here we analyze the dynamics of the seismicity distribution before a number of strong earthquakes occurred in two seismically active regions of the world: Japan and Southern California. In order to study the evolution of spatial inhomogeneity of the seismicity distribution, we consider variations of two multifractal characteristics: information entropy of multifractal measure generation process and the higher-order generalized fractal dimension of the continuum of the earthquake epicenters. Also we studied the dynamics of the level of spatio-temporal correlations in the seismicity distribution. It is found that two aforementioned multifractal characteristics tend to decrease and the level of spatio-temporal correlations tends to increase before the majority of considered strong earthquakes. Such a tendency can be considered as an earthquake precursory signature. Therefore, the results obtained show the possibility to use multifractal and correlation characteristics of the spatio-temporal distribution of regional seismicity for seismic hazard risk evaluation

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule

It has been suggested that a sub-population of orexinergic neurones whose somata lie in the lateral hypothalamic area (LHA) play an important role in regulating the reinforcing value of both food and drugs. This experiment examined the effect of disruption of orexinergic mechanisms in the LHA on performance on the progressive-ratio schedule of reinforcement, in which the response requirement increases progressively for successive reinforcers. The data were analysed using a mathematical model which yields a quantitative index of reinforcer value and dissociates effects of interventions on motor and motivational processes (Killeen, 1994). Rats were trained under a progressive-ratio schedule using food-pellet reinforcement. They received bilateral injections of conjugated orexin-B-saporin (OxSap) into the LHA or sham lesions. Training continued for a further 40 sessions after surgery. Equations were fitted to the response rate data from each rat, and the parameters of the model were derived for successive blocks of 10 sessions. The OxSap lesion reduced the number of orexin-containing neurones in the LHA by approximately 50% compared to the sham-lesioned group. The parameter expressing the incentive value of the reinforcer was not significantly altered by the lesion. However, the parameter related to the maximum response rate was significantly affected, suggesting that that motor capacity was diminished in the OxSap-lesioned group. The results indicate that OxSap lesions of the LHA disrupted food-reinforced responding on the progressive-ratio schedule. It is suggested that this disruption was brought about by a change in non-motivational (motor) processes