Facility Location with Spatially Interactive Travel Behavior

This paper sets out a spatially interactive facility location model that specifies client travel behavior according to a "gravity" formula. The well-known uncapacitated facility location model is a limiting case of this model. Analytical partial optimization yields a condensed formulation that can be solved by a nonlinear branch-and-bound approach. Computational results are presented for several problems having as many as 69 potential facility locations

Relativistic tunneling through opaque barriers

We propose an analytical study of relativistic tunneling through opaque barriers. We obtain a closed formula for the phase time. This formula is in excellent agreement with the numerical simulations and corrects the standard formula obtained by the stationary phase method. An important result is found when the upper limit of the incoming energy distribution coincides with the upper limit of the tunneling zone. In this case, the phase time is proportional to the barrier width.Comment: 11 pages, 3 figure

Ultrastructural Alterations in Lepocinclis acus (Euglenophyta) Induced by Medium with High Organic Matter Content

Ultrastructural changes induced by exposure to excess of organic matter were studied in Lepocinclis acus (ex Euglena acus). The cells isolated from the Matanza River, Buenos Aires, Argentina, were grown in soil water medium (SWM). When transferred to medium enriched with Bacteriological Peptone OXOID®, marked body deformation and a significant shortening and widening of the cells was observed. These changes were unexpected in a species with quite rigid cells, a condition previously shown in studies of the pellicle fine structure. Transmission electron microscopy observations suggest that cellular deformation might be facilitated by an increase in strip number, whereas in the original strips normal ultrastructure was maintained. An increase in number and volume of paramylon grains and vacuoles, as well as the presence of membrane whorls in vacuoles was observed. The fine structure of organisms grown in medium with and without organic matter enrichment was compared, and the systematic and ecological importance of morphological changes triggered by cell deformation was discussed.Fil: Conforti, Visitacion Teresa D.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Ruiz, Laura Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Leonardi, Patricia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentin

Preferential attachment in the growth of social networks: the case of Wikipedia

We present an analysis of the statistical properties and growth of the free on-line encyclopedia Wikipedia. By describing topics by vertices and hyperlinks between them as edges, we can represent this encyclopedia as a directed graph. The topological properties of this graph are in close analogy with that of the World Wide Web, despite the very different growth mechanism. In particular we measure a scale--invariant distribution of the in-- and out-- degree and we are able to reproduce these features by means of a simple statistical model. As a major consequence, Wikipedia growth can be described by local rules such as the preferential attachment mechanism, though users can act globally on the network.Comment: 4 pages, 4 figures, revte

Low-complexity motion estimation for the Scalable Video Coding extension of H.264/AVC

The recently standardized Scalable Video Coding(SVC) extension of H.264/AVC allows bitstream scalability with improved rate-distortion efficiency with respect to the classical Simulcasting approach, at the cost of an increased computational complexity of the encoding process. So one critical issue related to practical deployment of SVC is the complexity reduction, fundamental to use it in consumer applications. In this paper, we present a fully scalable fast motion estimation algorithm that enables an excellent complexity performance

Network Awareness of P2P Live Streaming Applications

Early P2P-TV systems have already attracted millions of users, and many new commercial solutions are entering this market. Little information is however available about how these systems work. In this paper we present large scale sets of experiments to compare three of the most successful P2P-TV systems, namely PPLive, SopCast and TVAnts. Our goal is to assess what level of "network awareness" has been embedded in the applications, i.e., what parameters mainly drive the peer selection and data exchange. By using a general framework that can be extended to other systems and metrics, we show that all applications largely base their choices on the peer bandwidth, i.e., they prefer high-bandwidth users, which is rather intuitive. Moreover, TVAnts and PPLive exhibits also a preference to exchange data among peers in the same autonomous system the peer belongs to. However, no evidence about preference versus peers in the same subnet or that are closer to the considered peer emerges. We believe that next-generation P2P live streaming applications definitively need to improve the level of network-awareness, so to better localize the traffic in the network and thus increase their network-friendliness as wel

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer.

Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy. In this context, Vδ2pos T cells represent the preferential target of several immunotherapy protocols against solid tumors. However, the impact of both aging and chemotherapy (CHT) on Vδ2pos T cells is still unknown. The present study evaluates with multi-parametric flow cytometry the frequencies, terminal differentiation, senescence and effector-functions of peripheral blood and tumor infiltrating Vδ2pos T cells purified from liver metastases (CLM) of patients affected by colorectal cancer (CRC) compared to those of sex- and age-matched healthy donors. The peripheral blood of CLM patients underwent CHT is characterized by decreased amounts of Vδ2pos T cells showing a relative increase of terminally-differentiated CD27neg/CD45RApos (TEMRA) cells. The enrichment of this latter subset is associated with an increased expression of the senescent marker CD57. The acquisition of CD57 on TEMRA Vδ2pos T cells is also coupled with impairments in cytotoxicity and production of TNF-α and IFN-γ. These features resemble the acquisition of an immune-senescent profile by Vδ2pos T cells from CLM patients that received CHT, a phenomenon that is also associated with the loss of the co-stimulatory marker CD28 and with the induced expression of CD16. The group of CLM patients underwent CHT and older than 60 years old showed higher frequencies of CD57pos and TEMRA Vδ2pos T cells. Similar results were found for tumor infiltrating Vδ2pos T cell subset purified from CLM specimens of patients treated with CHT. The toxicity of CHT regimens also affects the homeostasis of Vδ2pos T cells by inducing higher frequencies of circulating CD57pos TEMRA subset in CLM underwent CHT and younger than 60 years old. Taken together, our data demonstrate that the enrichment of senescent Vδ2pos T cells in CLM patients is not only induced by patients' aging but also by the toxicity of CHT that further accelerates the accumulation of CD57pos TEMRA cells highly dysfunctional in their anti-tumor activities. These results are important to both predict the clinical outcome of CLM and to optimize those protocols of cell cancer immunotherapy employing unconventional Vδ2pos T cells

Evidence for a Young Stellar Population in NGC 5018

Two absorption line indices, Ca II and Hdelta/FeI4045, measured from high resolution spectra are used with evolutionary synthesis models to verify the presence of a young stellar population in NGC 5018. The derived age of this population is about ~2.8 Gyr with a metallicity roughly solar and it completely dominates the integrated light of the galaxy near 4000 A.Comment: 13 pages, 7 figures (figs 3-7 are color figures), to be published in the May 2000 issue of the Astrophysical Journa