UYSD: a novel data repository accessible via public website for worldwide population frequencies of Y-SNP haplogroups

For decades, there has been scientific interest in the variation and geographic distribution of paternal lineages associated with the human Y chromosome. However, the relevant data have been dispersed across numerous publications, making it difficult to consolidate. Additionally, understanding the relationships between different variants, and the tools used to analyze them, have evolved over time, further complicating efforts to harmonize this information. The Universal Y-SNP Database (UYSD) marks a substantial advancement by providing a comprehensive and accessible platform for Y-SNP and haplogroup data from populations around the world. UYSD harmonizes diverse datasets into a unified repository, facilitating the exploration of global Y-chromosomal variation. The platform handles data generated with both high- and low-throughput technology and is compatible with the automated analysis software tool, Yleaf v3. Key functionalities include the ability to: i) visualize haplogroup distributions on an interactive world map, ii) estimate haplogroup frequencies in geographic regions with sparse data through interpolation, and iii) display detailed phylogenetic trees of Y-chromosomal haplogroups. Currently, UYSD encompasses data from over 6,600 males across 27 populations. This dataset largely aligns with known global Y-haplogroup patterns, but also reveals unexplored finer-scale geographic variations. While the present dataset is largely European-centered, UYSD is designed for ongoing expansion by the scientific community, aiming to include more global data and higher-resolution population sequencing data. The platform thus offers valuable insights into human genetic diversity and migration patterns, serving several fields of research such as: human population genetics, genetic anthropology, ancient DNA analysis and forensic genetics

International evidence-based recommendations on ultrasound-guided vascular access

n/

The genetic basis of craniofacial and dental abnormalities

The embryonic head development, including the formation of dental structures, is a complex and delicate process guided by specific genetic programs. Genetic changes and environmental factors can disturb the execution of these programs and result in abnormalities in orofacial and dental structures. Orofacial clefts and hypodontia/ oligodontia are examples of such abnormalities frequently seen in dental clinics. An insight into the mechanisms and genes involved in the formation of orofacial and dental structures has been gradually gained by genetic analysis of families and by the use of experimental vertebrate models such as the mouse and chick models. The development of novel clinical therapies for orofacial and dental pathological conditions depends very much on a detailed knowledge of the molecular and cellular processes that are involved in head formation

An instructional design process for creating a U-learning ecology

The ubiquitous computing (UbiComp) is considered as an extension of the computational capabilities of the physical environment, allowing the computational structure to be present everywhere in the form of small, robust, networked processing devices distributed at all scales through everyday life and generally turned to distinctly common place ends. There are various research challenges regarding the design and use of instructional design tools in complex learning contexts such as Ubiquitous Computing, Mobile learning (m-learning) and Internet of Things (IoT), the technologies defined as UMI technologies. This paper presents the rationale, important issues and methodology constructed in the context of UbiComp so as to initially define an instructional design process for building a U – Learning Ecology for multidisciplinary education. We provide a consistent framework and structural view of integrating instructional design principles in UbiComp learning: we discuss our ideas on the design of a U-learning ecology by the gradual building of a robust design process and we provide an overview of our ongoing work on design/analysis tools supporting early stage prototyping for using UMI technologies

Developing a Design Framework for UMI Educational Scenarios

Ubiquitous learning (u-learning) is a new paradigm which is based on ubiquitous computing technology. The most significant role of ubiquitous computing technology in u-learning is to construct a ubiquitous learning environment which enables anyone to learn at anytime anyplace. Nonetheless the characteristics of u-learning are still unclear and being debated by the research community. Designing instructional tools that actually promote u-learning experiences is a cumbersome task in the sense of taking into consideration and combining a variety of complex, technological tools and characteristics of u-learning. This study describes the characteristics and design methodology of a UMI-Sci-Ed* Educational Scenario Template as a medium to organize and construct u-learning experiences based in a u-learning environment. It also presents a case study scenario, based on UMI Subject Matter Experts’ interaction with the predefined and designed Educational Scenario Components