Where's the harm? A social marketing approach to reframing 'problem' drinking cultures

Alcohol consumption is often linked to a broad range of social and health problems, yet alcohol also plays a fundamental role in social bonding between people. This paper considers the potential of social marketing to contribute to alcohol consumption reduction and reframe social norms that encourage 'problem' drinking. Based on qualitative research with a variety of Scottish drinkers, the paper emphasises how and why a better understanding of the culturally bound meanings of alcohol (e.g. social identity, self-concept) are of crucial importance to inform any social marketing approach to reframing excessive drinking

ABCB1 Overexpression Is a key initiator of resistance to tyrosine kinase inhibitors in CML cell lines

The tyrosine kinase inhibitor (TKI) imatinib has resulted in excellent responses in the majority of Chronic Myeloid Leukaemia (CML) patients; however, resistance is observed in 20-30% of patients. More recently, resistance to the second generation TKIs, nilotinib and dasatinib, has also been observed albeit at a lower incidence. ABCB1 has previously been implicated in TKI export and its overexpression linked to TKI resistance. In this study the dynamics of nilotinib resistance was studied in CML cell lines with particular focus on ABCB1 expression levels during development of resistance. Results revealed ABCB1 overexpression is likely an important initiator of nilotinib resistance in vitro. ABCB1 overexpression was also observed in cell lines as an intermediate step during development of resistance to imatinib and dasatinib in vitro. We conclude that ABCB1 overexpression may provide an initial platform to facilitate development of additional mechanisms for resistance to TKIs. This provides a rationale for investigating this phenomenon in patients undergoing TKI therapy.Laura N. Eadie, Timothy P. Hughes, Deborah L. Whit

Globular Cluster Systems in Brightest Cluster Galaxies. III: Beyond Bimodality

We present new deep photometry of the rich globular cluster (GC) systems around the Brightest Cluster Galaxies UGC 9799 (Abell 2052) and UGC 10143 (Abell 2147), obtained with the HST ACS and WFC3 cameras. For comparison, we also present new reductions of similar HST/ACS data for the Coma supergiants NGC 4874 and 4889. All four of these galaxies have huge cluster populations (to the radial limits of our data, comprising from 12000 to 23000 clusters per galaxy). The metallicity distribution functions (MDFs) of the GCs can still be matched by a bimodal-Gaussian form where the metal-rich and metal-poor modes are separated by ~0.8 dex, but the internal dispersions of each mode are so large that the total MDF becomes very broad and nearly continuous from [Fe/H] = -2.4 to Solar. There are, however, significant differences between galaxies in the relative numbers of \emph{metal-rich} clusters, suggesting that they underwent significantly different histories of mergers with massive, gas-rich halos. Lastly, the proportion of metal-poor GCs rises especially rapidly outside projected radii R > 4 R_eff, suggesting the importance of accreted dwarf satellites in the outer halo. Comprehensive models for the formation of GCs as part of the hierarchical formation of their parent galaxies will be needed to trace the systematic change in structure of the MDF with galaxy mass, from the distinctly bimodal form in smaller galaxies up to the broad continuum that we see in the very largest systems.Comment: In press for Astrophysical Journa

C5AC_5^A axial form factor from bubble chamber experiments

A careful reanalysis of both Argonne National Laboratory and Brookhaven National Laboratory data for weak single pion production is done. We consider deuteron nuclear effects and normalization (flux) uncertainties in both experiments. We demonstrate that these two sets of data are in good agreement. For the dipole parametrization of $C_5^A(Q^2)$, we obtain $C_5^A(0)=1.19\pm 0.08$, $M_A=0.94\pm 0.03$ GeV. As an application we present the discussion of the uncertainty of the neutral current 1$\pi^0$ production cross section, important for the T2K neutrino oscillation experiment.Comment: 16 pages, 8 figures, 2 table

Statistical Mechanics of the Quantum K-Satisfiability problem

We study the quantum version of the random $K$-Satisfiability problem in the presence of the external magnetic field $\Gamma$ applied in the transverse direction. We derive the replica-symmetric free energy functional within static approximation and the saddle-point equation for the order parameter: the distribution $P[h(m)]$ of functions of magnetizations. The order parameter is interpreted as the histogram of probability distributions of individual magnetizations. In the limit of zero temperature and small transverse fields, to leading order in $\Gamma$ magnetizations $m \approx 0$ become relevant in addition to purely classical values of $m \approx \pm 1$. Self-consistency equations for the order parameter are solved numerically using Quasi Monte Carlo method for K=3. It is shown that for an arbitrarily small $\Gamma$ quantum fluctuations destroy the phase transition present in the classical limit $\Gamma=0$, replacing it with a smooth crossover transition. The implications of this result with respect to the expected performance of quantum optimization algorithms via adiabatic evolution are discussed. The replica-symmetric solution of the classical random $K$-Satisfiability problem is briefly revisited. It is shown that the phase transition at T=0 predicted by the replica-symmetric theory is of continuous type with atypical critical exponents.Comment: 35 pages, 23 figures; changed abstract, improved discussion in the introduction, added references, corrected typo

Comparison between methods for the determination of the primary cosmic ray mass composition from the longitudinal profile of atmospheric cascades

The determination of the primary cosmic ray mass composition from the longitudinal development of atmospheric cascades is still a debated issue. In this work we discuss several data analysis methods and show that if the entire information contained in the longitudinal profile is exploited, reliable results may be obtained. Among the proposed methods FCC ('Fit of the Cascade Curve'), MTA ('Multiparametric Topological Analysis') and NNA ('Neural Net Analysis') with conjugate gradient optimization algorithm give the best accuracy.Comment: 22 pages, 11 figures, accepted by Astroparticle Physics, minor misprints and an extra figure remove

A Pilot Study Of Antihypertensive Therapy In Cerebrovascular Disease

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111248/1/j.1532-5415.1967.tb02802.x.pd

On the muon neutrino mass

During the runs of the PS 179 experiment at LEAR of CERN, we photographed an event of antiproton-Ne absorption, with a complete pi+ -> mu+ ->e+ chain. From the vertex of the reaction a very slow energy pi+ was emitted. The pi+ decays into a mu+ and subsequently the mu+ decays into a positron. At the first decay vertex a muon neutrino was emitted and at the second decay vertex an electron neutrino and a muon antineutrino. Measuring the pion and muon tracks and applying the momentum and energy conservation and using a classical statistical interval estimator, we obtained an experimental upper limit for the muon neutrino mass: m_nu < 2.2 MeV at a 90% confidence level. A statistical analysis has been performed of the factors contributing to the square value of the neutrino mass limit.Comment: 18 pages, 5 eps figure

A New Technique for Finding Needles in Haystacks: A Geometric Approach to Distinguishing Between a New Source and Random Fluctuations

We propose a new test statistic based on a score process for determining the statistical significance of a putative signal that may be a small perturbation to a noisy experimental background. We derive the reference distribution for this score test statistic; it has an elegant geometrical interpretation as well as broad applicability. We illustrate the technique in the context of a model problem from high-energy particle physics. Monte Carlo experimental results confirm that the score test results in a significantly improved rate of signal detection.Comment: 5 pages, 4 figure

The Topology and Size of the Universe from the Cosmic Microwave Background

We study the possibility that the universe has compact topologies T^3, T^2 x R^1, or S^1 x R^2 using the seven-year WMAP data. The maximum likelihood 95% confidence intervals for the size L of the compact direction are 1.7 < L/L_0 < 2.1, 1.8 < L/L_0 < 2.0, 1.2 < L/L_0 < 2.1 for the three cases, respectively, where L_0=14.4 Gpc is the distance to the last scattering surface. An infinite universe is compatible with the data at 4.3 sigma. We find using a Bayesian analysis that the most probable universe has topology T^2 x R^1, with L/L_0=1.9.Comment: Additional checks, Monte-Carlo skies, and study of dipole contamination added. References added. 13 pages, 11 figure