595 research outputs found
Improved negative predictive value of EBUS-TBNA in isolated mediastinal / hilar lymphadenopathy::Why and what it means for patients?
An Experimental Test of a Reward-Cost Formulation of Status Inconsistency
The authors develop a theory in which consistency of ranks on position and ability affect individual satisfaction and system stability. The mechanism is rewards associated with different patterns. For instance, when position is rewarded more than ability, a low ability individual with a high position will be satisfied; when position and ability are rewarded equally, then rank consistency will be most satisfactory
Climatic controls on diffuse groundwater recharge across Australia
Reviews of field studies of groundwater recharge have attempted to investigate how climate characteristics control recharge, but due to a lack of data have not been able to draw any strong conclusions beyond that rainfall is the major determinant. This study has used numerical modelling for a range of Köppen-Geiger climate types (tropical, arid and temperate) to investigate the effect of climate variables on recharge for different soil and vegetation types. For the majority of climate types, the correlation between the modelled recharge and total annual rainfall is weaker than the correlation between recharge and the annual rainfall parameters reflecting rainfall intensity. Under similar soil and vegetation conditions for the same annual rainfall, annual recharge in regions with winter-dominated rainfall is greater than in regions with summer-dominated rainfall. The importance of climate parameters other than rainfall in recharge estimation is highest in the tropical climate type. Mean annual values of solar radiation and vapour pressure deficit show a greater importance in recharge estimation than mean annual values of the daily mean temperature. Climate parameters have the lowest relative importance in recharge estimation in the arid climate type (with cold winters) and the temperate climate type. For 75% of all soil, vegetation and climate types investigated, recharge elasticity varies between 2 and 4 indicating a 20% to 40% change in recharge for a 10% change in annual rainfall. Understanding how climate controls recharge under the observed historical climate allows more informed choices of analogue sites if they are to be used for climate change impact assessments
Multi-Characteristic Status Situations and the Determination of Power and Prestige Order
This technical report builds on the research reported in Technical Report 32. It reports a second experiment investigating how two status characteristics affect expectations and power and prestige. The theoretical goal was to further compare predictions based on combining all status information and predictions based on "balancing" or ignoring some information. The combining assumption was later incorporated in the general theory
Status Inconsistency, Status Aspiration, Task Mobility, and Preferences for Specialization and Despecialization of Group Task Structure
This technical report is a further elaboration of the exchange-based theory of status consistency and individuals’ reactions to various patterns that was presented in technical report 21. The extended theory predicts mobility and preferences for more and less differentiated task structures as outcomes of different patterns of inconsistency. Experimental test results were generally confirmatory
Applying a brain-computer interface to support motor imagery practice in people with stroke for upper limb recovery: A feasibility study
<p>Abstract</p> <p>Background</p> <p>There is now sufficient evidence that using a rehabilitation protocol involving motor imagery (MI) practice in conjunction with physical practice (PP) of goal-directed rehabilitation tasks leads to enhanced functional recovery of paralyzed limbs among stroke sufferers. It is however difficult to confirm patient engagement during an MI in the absence of any on-line measure. Fortunately an EEG-based brain-computer interface (BCI) can provide an on-line measure of MI activity as a neurofeedback for the BCI user to help him/her focus better on the MI task. However initial performance of novice BCI users may be quite moderate and may cause frustration. This paper reports a pilot study in which a BCI system is used to provide a computer game-based neurofeedback to stroke participants during the MI part of a protocol.</p> <p>Methods</p> <p>The participants included five chronic hemiplegic stroke sufferers. Participants received up to twelve 30-minute MI practice sessions (in conjunction with PP sessions of the same duration) on 2 days a week for 6 weeks. The BCI neurofeedback performance was evaluated based on the MI task classification accuracy (CA) rate. A set of outcome measures including action research arm test (ARAT) and grip strength (GS), was made use of in assessing the upper limb functional recovery. In addition, since stroke sufferers often experience physical tiredness, which may influence the protocol effectiveness, their fatigue and mood levels were assessed regularly.</p> <p>Results</p> <p>Positive improvement in at least one of the outcome measures was observed in all the participants, while improvements approached a minimal clinically important difference (MCID) for the ARAT. The on-line CA of MI induced sensorimotor rhythm (SMR) modulation patterns in the form of lateralized event-related desynchronization (ERD) and event-related synchronization (ERS) effects, for novice participants was in a moderate range of 60-75% within the limited 12 training sessions. The ERD/ERS change from the first to the last session was statistically significant for only two participants.</p> <p>Conclusions</p> <p>Overall the crucial observation is that the moderate BCI classification performance did not impede the positive rehabilitation trends as quantified with the rehabilitation outcome measures adopted in this study. Therefore it can be concluded that the BCI supported MI is a feasible intervention as part of a post-stroke rehabilitation protocol combining both PP and MI practice of rehabilitation tasks. Although these findings are promising, the scope of the final conclusions is limited by the small sample size and the lack of a control group.</p
Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder
Background Recurrent microdeletions and microduplications of w555 kb at 16p11.2 confer susceptibility to autism spectrum disorder (ASD) in up to 1% of ASD patients. No physical or behavioural features have been identified that distinguish these individuals as having a distinct ASD subtype, but clinical data are limited. Methods We report five autistic probands identified by microarray analysis with copy number variation (CNV) of 16p11.2 (three deletions, two duplications). Each patient was assessed for ASD and dysmorphic features. We also describe a deletion positive 26-month-old female who has developmental delay (DD) and autistic features. Results Proband 1 (female with ASD, de novo deletion) is not dysmorphic. Proband 2 (male with autism, de novo deletion) and proband 3 and his brother (males with autism, inherited deletions) are dysmorphic, but the two probands do not resemble one another. The mother of proband 3 has mild mental retardation (MR), minor dysmorphism and meets the criteria for ASD. Proband 4 (dysmorphic autistic male, de novo duplication) had a congenital diaphragmatic hernia. Proband 5 (nondysmorphic ASD female with a duplication) has two apparently healthy duplication positive relatives. Probands 1 and 2 have deletion negative siblings with ASD and Asperger syndrome, respectively. Proband 6 (a female with DD and an inherited duplication) is dysmorphic, but has oligohydramnios sequence. Conclusions The phenotypic spectrum associated with CNV at 16p11.2 includes ASD, MR/DD and/or possibly other primary psychiatric disorders. Compared with the microduplications, the reciprocal microdeletions are more likely to be penetrant and to be associated with nonspecific major or minor dysmorphism. There are deletion positive ASD probands with a less severe phenotype than deletion negative ASD siblings underscoring the significant phenotypic heterogeneity.published_or_final_versio
Energy Dependence of Nuclear Transparency in C(p,2p) Scattering
The transparency of carbon for (p,2p) quasi-elastic events was measured at
beam energies ranging from 6 to 14.5 GeV at 90 degrees c.m. The four momentum
transfer squared q*q ranged from 4.8 to 16.9 (GeV/c)**2. We present the
observed energy dependence of the ratio of the carbon to hydrogen cross
sections. We also apply a model for the nuclear momentum distribution of carbon
to normalize this transparency ratio. We find a sharp rise in transparency as
the beam energy is increased to 9 GeV and a reduction to approximately the
Glauber level at higher energies.Comment: 4 pages, 2figures, submitted to PR
Suicidal crisis among children and young people: Associations with adverse childhood experiences and socio-demographic factors
Suicide is a major public health issue and a leading cause of death among children and young people (CYP) worldwide. There is strong evidence linking adverse childhood experiences (ACEs) to an increased risk of suicidal behaviours in adults, but there is limited understanding regarding ACEs and suicidal crisis in CYP. This study aims to examine the ACEs associated with CYP presenting at Emergency Departments for suicidal crisis, and specifically the factors associated with repeat attendances. This is a case series study of CYP (aged 8–16) experiencing suicidal crisis who presented in a paediatric Emergency Department in England between March 2019 and March 2021 (n=240). The dataset was subjected to conditional independence graphical analysis. Results revealed a significant association between suicidal crisis and several ACEs. Specifically, evidence of clusters of ACE variables suggests two distinct groups of CYP associated with experiencing suicidal crisis: those experiencing ‘household risk’ and those experiencing ‘parental risk’. Female sex, history of self-harm, mental health difficulties, and previous input from mental health services were also as- sociated with repeat hospital attendances. Findings have implications for early identification of and intervention with children who may be at a heightened risk for ACEs and associated suicidal crisis
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