1,573 research outputs found

    Extraocular muscle sampled volume in Graves' orbitopathy using 3-T fast spin-echo MRI with iterative decomposition of water and fat sequences

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    Abstract Background: Current magnetic resonance imaging (MRI) techniques for measuring extraocular muscle (EOM) volume enlargement are not ideally suited for routine follow-up of Graves’ ophthalmopathy (GO) because the difficulty of segmenting the muscles at the tendon insertion complicates and lengthens the study protocol. Purpose: To measure the EOM sampled volume (SV) and assess its correlation with proptosis. Material and Methods: A total of 37 patients with newly diagnosed GO underwent 3-T MRI scanning with iterative decomposition of water and fat (IDEAL) sequences with and without contrast enhancement. In each patient, the three largest contiguous coronal cross-sectional areas (CSA) on the EOM slices were segmented using a polygon selection tool and then summed to compute the EOM-SV. Proptosis was evaluated with the Hertel index (HI). The relationships between the HI value and EOM-SV and between HI and EOM-CSA were compared and assessed with Pearson’s correlation coefficient and the univariate regression coefficient. Inter-observer and intra-observer variability were calculated. Results: HI showed a stronger correlation with EOM-SV (P<0.001; r¼0.712, r2¼0.507) than with EOM-CSA (P<0.001; r¼0.645 and r2¼0.329). The intraclass correlation coefficient indicated that the inter-observer agreement was high (0.998). The standard deviation between repeated measurements was 1.9–5.3%. Conclusion: IDEAL sequences allow for the measurement EOM-SV both on non-contrast and contrast-enhanced scans. EOM-SV predicts proptosis more accurately than does EOM-CSA. The measurement of EOM-SV is practical and reproducible. EOM-SV changes of 3.5–8.3% can be assumed to reflect true volume changes

    Approaching Skyscape Archaeology: A Note on Method and Fieldwork for the Case Study of Pompeii

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    The urban layout of Pompeii presents several orientations, possibly due to an uneven bare ground plateau. However, its main east-west axes have the same orientation of Herculaneum ones, suggesting that not only geomorphological constrains acted as topographical factors. Starting from a hypothesis by Nissen (1906), the method of skyscape archaeology was applied to Pompeii urban grid and temples, testing digital models with fieldwork measurements. The results show that the main east-west axes aligned with the rising summer solstice sun above the local horizon. Furthermore, the Doric Temple was oriented with the sunset on the same time of the year, suggesting an intentional design

    Multiconsensus control of homogeneous LTI hybrid systems under time-driven jumps

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    In this paper, we consider a network of homogeneous LTI hybrid dynamics under time-driven aperiodic jumps and exchanging information over a fixed communication graph. Based on the notion of almost equitable partitions, we explicitly characterize the clusters induced by the network over the nodes and, consequently, the corresponding multi-consensus trajectories. Then, we design a decentralized control ensuring convergence of all agents to the corresponding multi-consensus trajectory. Simulations over an academic example illustrate the results

    Genetic and morphological studies of Trichosirocalus species introduced to North America, Australia and New Zealand for the biological control of thistles

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    Trichosirocalus horridus sensu lato has been used as a biological control agent of several invasive thistles (Carduus spp., Cirsium spp. and Onopordum spp.) since 1974. It has been recognized as a single species until 2002, when it was split into three species based on morphological characters: T. horridus, Trichosirocalus briesei and Trichosirocalus mortadelo, each purported to have different host plants. Because of this taxonomic change, uncertainty exists as to which species were released in various countries; furthermore, there appears to be some exceptions to the purported host plants of some of these species. To resolve these questions, we conducted an integrative taxonomic study of the T. horridus species complex using molecular genetic and morphological analyses of specimens from three continents. Both mitochondrial cytochrome c oxidase subunit I and nuclear elongation factor 1α markers clearly indicate that there are only two distinct species, T. horridus and T. briesei. Molecular evidence, morphological analysis and host plant associations support the synonymy of T. horridus (Panzer, 1801) and T. mortadelo Alonso-Zarazaga & Sánchez-Ruiz, 2002. We determine that T. horridus has been established in Canada, USA, New Zealand and Australia and that T. briesei is established in Australia. The former species was collected from Carduus, Cirsium and Onopordum spp. in the field, whereas the latter appears to be specific to Onopordum

    Non-Financial Resources to Enhance Companies’ Profitability: A Stakeholder Perspective

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    Purpose This study aims to investigate the impact of stakeholders’ nonfinancial resources (NFRs) on companies’ profitability, filling a significant gap in the literature regarding the role of NFRs in value creation. Design/methodology/approach Data from 76 organizations from 2017 to 2019 were collected and analyzed. Four primary NFRs and their key value drivers were identified, representing core elements that support different dimensions of a company’s performance. Statistical tests examined the relationship between stakeholders’ NFRs and financial performance measures. Findings When analyzed collectively and individually, the results reveal a significant positive influence of stakeholders’ NFRs on a firm’s profitability. Higher importance assigned to NFRs correlates with a higher return on sales. Originality/value This study contributes to the literature by empirically bridging the gap between stakeholder theory and the resource-based view, addressing the intersection of these perspectives. It also provides novel insights into how stakeholders’ NFRs impact profitability, offering valuable implications for research and managerial practice. It suggests that managers should integrate nonfinancial measures of NFRs within their performance measurement system to manage better and sustain companies’ value-creation process

    Exploring the Entrepreneurial Jungle: Unicorns, Gazelles, Zebras, and Other Venture Species

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    This paper proposes pioneering the exploration of new entrepreneurial species as a novel and essential research avenue within the entrepreneurship domain. By likening entrepreneurial ventures to diverse species inhabiting a jungle, the study ventures into unexplored territories of entrepreneurial taxonomy. It advocates delving into distinct classifications such as unicorns, zebras, and gazelles, offering a fresh perspective on their impact on economies and societies. The research argues for the relevance of these unique ventures, emphasizing their significant influence on entrepreneurial thought and challenging traditional theories. By shedding light on uncharted species and their inter-relationships, the paper opens promising avenues for future research, contributing to the evolving landscape of entrepreneurship studies

    Business network paradoxes: A literature review and co-evolutionary perspective

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    How can studying paradoxes in business networks help understand the networks' adaptation and survival? IMP identifies three central paradoxes influencing business networks: i) Development of Relationships vs. Inability to Change, ii) Controlling vs. Effectiveness, and iii) Stability vs. Change. Studying them seems critical to knowing how interdependent participants in business networks adapt to one another. To do that, we use a co-evolutionary lens to review 41 articles dealing with business network paradoxes from an IMP perspective. Results of the Reflexive Thematic Analysis underline that salient tensions mainly originate from weak coordinating norms, resource misallocation, the relationship of newness and aging, and Machiavellian behaviour. As the main value of our work, we then advance that embracing a co-evolutionary perspective can help shed novel light on these paradoxes by contrasting the factors that make the tensions salient with those able to overcome them. Specifically, we identify moral behaviour, structuration of the network, network capability development, and co-adaptation as four main factors that mitigate the paradoxes and help networks' adaptation and survival. Accordingly, we advocate a co-evolutionary conceptual framework regarding paradoxes and outline five co-evolutionary claims as implications for research and practice
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