Electronic integrator for gyro rate output voltages

Circuit which integrates spacecraft gyro output voltages to provide analog position signals has been developed. Accurate integration is provided by all solid state system which uses no choppers and takes advantage of commercially available flight qualified components

MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat

A two-year-old cat was presented with a left paradoxical vestibular syndrome. MRI of the brain revealed an extra-axial homogenously contrast enhancing mass in the region of the left caudal cerebellar peduncle. Toxoplasma serology was consistent with active infection and the lesion was suspected to be a toxoplasma granuloma. Following eight weeks of tapering oral prednisolone and 11 weeks of oral clindamycin treatment, repeat MRI revealed resolution of the lesion. Eighteen months after initial diagnosis, the cat remained neurologically normal. Differential diagnoses for a solitary, extra-axial, contrast enhancing mass lesion in the feline brain should include toxoplasma granuloma, which can undergo MRI and clinical resolution with medical treatment

Science and Applications Space Platform (SASP) End-to-End Data System Study

The capability of present technology and the Tracking and Data Relay Satellite System (TDRSS) to accommodate Science and Applications Space Platforms (SASP) payload user's requirements, maximum service to the user through optimization of the SASP Onboard Command and Data Management System, and the ability and availability of new technology to accommodate the evolution of SASP payloads were assessed. Key technology items identified to accommodate payloads on a SASP were onboard storage devices, multiplexers, and onboard data processors. The primary driver is the limited access to TDRSS for single access channels due to sharing with all the low Earth orbit spacecraft plus shuttle. Advantages of onboard data processing include long term storage of processed data until TRDSS is accessible, thus reducing the loss of data, eliminating large data processing tasks at the ground stations, and providing a more timely access to the data

Modified confidence intervals for the Mahalanobis distance

Reiser (2001) proposes a method of forming confidence interval for a Mahalanobis distance that yields intervals which have exactly the nominal coverage, but sometimes the interval is View the MathML source (0,0). We consider the case where Mahalanobis distance quantifies the difference between an individual and a population mean, and suggest a modification that avoids implausible intervals

Scaling and singularities in the entrainment of globally-coupled oscillators

The onset of collective behavior in a population of globally coupled oscillators with randomly distributed frequencies is studied for phase dynamical models with arbitrary coupling. The population is described by a Fokker-Planck equation for the distribution of phases which includes the diffusive effect of noise in the oscillator frequencies. The bifurcation from the phase-incoherent state is analyzed using amplitude equations for the unstable modes with particular attention to the dependence of the nonlinearly saturated mode $|\alpha_\infty|$ on the linear growth rate $\gamma$. In general we find $|\alpha_\infty|\sim \sqrt{\gamma(\gamma+l^2D)}$ where $D$ is the diffusion coefficient and $l$ is the mode number of the unstable mode. The unusual $(\gamma+l^2D)$ factor arises from a singularity in the cubic term of the amplitude equation.Comment: 11 pages (Revtex); paper submitted to Phys. Rev. Let

Selective Laser Sintering of Passive Dynamic Ankle-Foot Orthoses

Passive dynamic ankle-foot orthoses (AFO’s) are used to improve gait performance in those with various neuromuscular disorders. An important design characteristic of passive dynamic AFOs is the storage and release of elastic energy within its structure to help satisfy the energetic demands of walking. Thus, minimizing energy dissipation through internal friction is a fundamental criterion for selecting the appropriate AFO material. This study compared the mechanical damping of a carbon-fiber AFO to three geometrically identical AFO’s fabricated using selective laser sintering with different materials. Mechanical damping characteristics ranked the materials as Nylon 11 (best), followed by DuraformTM PA and DuraformTM GF (worst).Mechanical Engineerin

Net energy analysis of solar and conventional domestic hot water systems in Melbourne, Australia

It is commonly assumed that solar hot water systems save energy and reduce greenhouse gas emissions. Very rarely has the life-cycle energy requirements of solar hot water systems been analysed, including their embodied energy. The extent to which solar hot water systems save energy compared to conventional systems in Melbourne, Australia, is shown through a comparative net energy analysis. The solar systems provided a net energy saving compared to the conventional systems after 0.5 to 2 years, for electricity and gas systems respectively.<br /

Full-coverage film cooling heat transfer study: Summary of data for normal-hole injection and 30 deg slant-hole injection

Heat transfer to a full coverage film cooled turbulent boundary layer over a flat surface was studied. The surface consisted of a discrete hole test section containing 11 rows of holes spaced 5 diameters apart in a staggered array and an instrumented recovery region. Ten diameter spacing was also studied by plugging appropriate holes. Two test sections were used, one having holes normal to the surface and the other having holes angled 30 deg to the surface in the downstream direction. Stanton number data were obtained both in the full coverage region and in the downstream recovery region for a range of blowing ratios, or mass flux ratios, from 0 to 1.3. Initial conditions at the upstream edge of the blowing region were varied from 500 to 5000 for momentum thickness Reynolds number and from 100 to 1800 for enthalpy thickness Reynolds number. The range of Reynolds numbers based on hole diameter and mainstream velocity was 6000 to 22000. Initial boundary layer thicknesses range from 0.5 to 2.0 hole diameters. Air was used as the working fluid. The data were taken for the secondary injection temperature equal to the wall temperature and also equal to the mainstream temperature. Superposition was then used to obtain Stanton number as a continuous function of the injectant temperature. The heat transfer coefficient was defined on the basis of a mainstream-to-wall temperature difference. This definition permits direct comparison of performance between film cooling and transpiration cooling

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain

Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an intracellular family 1 cystatin) with KD2 and Delta L110 deletion mutants of chicken cystatin-KD2 hybrids. Substitution of the N-terminal contact region of stefin B by the corresponding KD2 sequence resulted in a calpain inhibitor of K-i = 188 nM. Deletion of L110, which forms a beta -bulge in family 1 and 2 cystatins but is lacking in KD2, improved inhibition of mu -calpain 4- to 8-fold. All engineered cystatins were temporary inhibitors of calpain due to slow substrate-like cleavage of a single peptide bond corresponding to Gly9-Ala10 in chicken cystatin. Biomolecular interaction analysis revealed that, unlike calpastatin, the cystatin-type inhibitors do not bind to the calmodulin-like domain of the small subunit of calpain, and their interaction with the mu -calpain heterodimer is completely prevented by a synthetic peptide comprising subdomain B of calpastatin domain 1. Based on these results we propose that (i) cystatin-type calpain inhibitors interact with the active site of the catalytic domain of calpain in a similar cystatin-like mode as with papain and (ii) the potential for calpain inhibition is due to specific subsites within the papain-binding regions of the general cystatin fold