New insights into coastal erosion rates along the Yukon coast, Canada

Approximately twice as much carbon is stored in permafrost (perennially frozen ground) as is in the Earth’s atmosphere. Globally, nearly one third of all coasts are affected by permafrost processes. Erosion of these coasts causes re-mobilization of the stored carbon which then becomes available for the conversion into greenhouse gasses, such as methane and carbon dioxide. The Yukon Coastal Plain in the western Canadian Arctic is typically composed of ice-rich and unconsolidated sediments, including massive ice bodies for example in the form of ice wedges and segregated ice. This composition and morphology make it highly susceptible to erosion. Recent changes in environmental conditions such as record low summer sea ice extents in the years of 2007 and 2012, and rising sea- and ground temperatures, suggest an increase in coastal retreat and thus an increase in the re-mobilization of carbon. We present the initial results of a regional study focused on the spatial and temporal changes of coastal retreat along a 200 km coastal stretch of the Yukon Coastal Plain, reaching from the USA-Canada border to Shingle Point. Aerial photography from 1951 to 1996, as well as SPOT and GeoEye satellite imagery from the years of 2009 and 2011, form the basis for GIS analyses using the Digital Shoreline Analysis System (DSAS). The results are supplemented by ground observations at seven coastal monitoring sites maintained by the Geological Survey of Canada. Infrared theodolite and real time kinematic global positioning system data, together with LiDAR (Light Detection And Ranging) data from 2012 and 2013, allow us to estimate the total volumetric land loss along the Yukon coast that occurred over the last 60 years. The temporal and spatial variability in coastal erosion shows that erosion occurs at rates up to 10 m/a around Stokes Point. Western study sites show much lower erosion rates of less than 2 m/a which appear to more adequately represent the overall erosional trend of the coast. The acceleration or deceleration of coastal retreat is highly dependent on the specific location, and varies from west to east. As the overall erosional behavior of the coast is very diverse, no clear response of the coast to changing environmental conditions can be distinguished yet. Further field investigations are planned, to gain a better understanding of how the Yukon coast is responding to environmental changes

Fate of OC in the Arctic nearshore zone: Rapid removal and degradation due to hydrodynamic and ice-related sediment transport

see pdf of extended abstrac

The center cannot hold: A Bayesian chronology for the collapse of Tiwanaku.

The timing of Tiwanaku's collapse remains contested. Here we present a generational-scale chronology of Tiwanaku using Bayesian models of 102 radiocarbon dates, including 45 unpublished dates. This chronology tracks four community practices: residing short- vs. long-term, constructing monuments, discarding decorated ceramics, and leaving human burials. Tiwanaku was founded around AD 100 and around AD 600, it became the region's principal destination for migrants. It grew into one of the Andes' first cities and became famous for its decorated ceramics, carved monoliths, and large monuments. Our Bayesian models show that monument building ended ~AD 720 (the median of the ending boundary). Around ~AD 910, burials in tombs ceased as violent deaths began, which we document for the first time in this paper. Ritualized murders are limited to the century leading up to ~AD 1020. Our clearest proxy for social networks breaking down is a precise estimate for the end of permanent residence, ~AD 1010 (970-1050, 95%). This major inflection point was followed by visitors who used the same ceramics until ~AD 1040. Temporary camps lasted until roughly ~AD 1050. These four events suggest a rapid, city-wide collapse at ~AD 1010-1050, lasting just ~20 years (0-70 years, 95%). These results suggest a cascading breakdown of community practices and social networks that were physically anchored at Tiwanaku, though visitors continued to leave informal burials for centuries. This generation-scale chronology suggests that collapse 1) took place well before reduced precipitation, hence this was not a drought-induced societal change and 2) a few resilient communities sustained some traditions at other sites, hence the chronology for the site of Tiwanaku cannot be transposed to all sites with similar material culture

Catching Element Formation In The Act

Gamma-ray astronomy explores the most energetic photons in nature to address some of the most pressing puzzles in contemporary astrophysics. It encompasses a wide range of objects and phenomena: stars, supernovae, novae, neutron stars, stellar-mass black holes, nucleosynthesis, the interstellar medium, cosmic rays and relativistic-particle acceleration, and the evolution of galaxies. MeV gamma-rays provide a unique probe of nuclear processes in astronomy, directly measuring radioactive decay, nuclear de-excitation, and positron annihilation. The substantial information carried by gamma-ray photons allows us to see deeper into these objects, the bulk of the power is often emitted at gamma-ray energies, and radioactivity provides a natural physical clock that adds unique information. New science will be driven by time-domain population studies at gamma-ray energies. This science is enabled by next-generation gamma-ray instruments with one to two orders of magnitude better sensitivity, larger sky coverage, and faster cadence than all previous gamma-ray instruments. This transformative capability permits: (a) the accurate identification of the gamma-ray emitting objects and correlations with observations taken at other wavelengths and with other messengers; (b) construction of new gamma-ray maps of the Milky Way and other nearby galaxies where extended regions are distinguished from point sources; and (c) considerable serendipitous science of scarce events -- nearby neutron star mergers, for example. Advances in technology push the performance of new gamma-ray instruments to address a wide set of astrophysical questions.Comment: 14 pages including 3 figure

Functional Genomics Unique to Week 20 Post Wounding in the Deep Cone/Fat Dome of the Duroc/Yorkshire Porcine Model of Fibroproliferative Scarring

Background: Hypertrophic scar was first described over 100 years ago; PubMed has more than 1,000 references on the topic. Nevertheless prevention and treatment remains poor, because 1) there has been no validated animal model; 2) human scar tissue, which is impossible to obtain in a controlled manner, has been the only source for study; 3) tissues typically have been homogenized, mixing cell populations; and 4) gene-by-gene studies are incomplete.Methodology/Principal Findings: We have assembled a system that overcomes these barriers and permits the study of genome-wide gene expression in microanatomical locations, in shallow and deep partial-thickness wounds, and pigmented and non-pigmented skin, using the Duroc( pigmented fibroproliferative)/Yorkshire( non-pigmented non-fibroproliferative) porcine model. We used this system to obtain the differential transcriptome at 1, 2, 3, 12 and 20 weeks post wounding. It is not clear when fibroproliferation begins, but it is fully developed in humans and the Duroc breed at 20 weeks. Therefore we obtained the derivative functional genomics unique to 20 weeks post wounding. We also obtained long-term, forty-six week follow-up with the model.Conclusions/Significance: 1) the scars are still thick at forty-six weeks post wounding further validating the model. 2) the differential transcriptome provides new insights into the fibroproliferative process as several genes thought fundamental to fibroproliferation are absent and others differentially expressed are newly implicated. 3) the findings in the derivative functional genomics support old concepts, which further validates the model, and suggests new avenues for reductionist exploration. in the future, these findings will be searched for directed networks likely involved in cutaneous fibroproliferation. These clues may lead to a better understanding of the systems biology of cutaneous fibroproliferation, and ultimately prevention and treatment of hypertrophic scarring.The National Institute on Disability and Rehabilitation ResearchThe National Institutes of HealthThe Washington State Council of Fire Fighters Burn FoundationThe Northwest Burn FoundationUniv Washington, Dept Surg, Div Plast Surg, Seattle, WA 98195 USAIowa State Univ, Dept Anim Sci, Ames, IA USAUniv Washington, Dept Biostat, Seattle, WA 98195 USAMahidol Univ, Ramathibodi Hosp, Dept Surg, Bangkok 10700, ThailandUniv Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USAUniversidade Federal de São Paulo, Div Plast Surg, Dept Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Div Plast Surg, Dept Surg, São Paulo, BrazilThe National Institute on Disability and Rehabilitation Research: H133G050022The National Institutes of Health: 1R21GM074673The National Institutes of Health: 5U54GM062119-09Web of Scienc

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Sensitivity of permafrost terrain in a high Arctic polar desert : an evaluation of response to disturbance near Eureka, Ellesmere Island, Nunavut

A first approximation of ground ice volume for the area surrounding Eureka, Nunavut, indicates that it comprises 30.8% of the upper 5.9 m of permafrost. Volume depends on the type of ice examined, ranging from 1.8 to 69.0% in different regions of the study area. Excess ice makes up 17.7% of the total volume of frozen materials in the study area. Melt of ground ice in the past has produced thermokarst features which include ground subsidence of up to 3.2 m, formation of tundra ponds, degradation of ice wedges, thaw slumps greater than 50 m across, gullying, and numerous active layer detachment slides. With a doubling of atmospheric carbon dioxide, the rise in mean annual temperatures for the area is projected to be 4.9 to 6.6°C, which would lengthen the thaw season and increase thaw depths by up to 70 cm. The expected geomorphic changes to the landscape are discussed

Mobilization of dissolved organic carbon (DOC) from permafrost due to arctic coastal erosion

Arctic permafrost coasts make up ~34% of the world’s coastline (ca. 400,000 km) and are often made of ice-rich unconsolidated sediments. This makes them highly susceptible to coastal erosion, and it is likely that large quantities of carbon are released, because permafrost soils are considered to hold approximately 50% of the global soil organic carbon pool. Current estimates of the carbon released by coastal erosion focus solely on particulate organic carbon (POC). Dissolved organic carbon (DOC) is generally not included in these calculations, because estimations of DOC contents in ground ice, which is overwhelmingly present along Arctic coasts, do not exist. In some cases, ground ice occupies as much as 90% of coastal bluffs with 40 m in height, where the coastline erodes at rates approaching 20 m/yr at its maximum. Here, we report DOC contents within permafrost from different ground ice types throughout the Arctic (Canada, Alaska, Siberia). We put them into context of Arctic organic carbon pools and fluxes, and evaluate their contribution to the Arctic carbon budget against the background of increasing permafrost degradation and enhancing coastal erosion in the future. For example, DOC concentrations in massive ground ice bodies including ice wedges range between <1.0 and 28.6 mg/L, while ice wedges have the greatest potential as DOC pool due to their wide spatial distribution in late Pleistocene and Holocene polygonal ground. Siberian Ice Complex deposits (Yedoma) are thought to consist of up to 50% of ice wedges by volume and are therefore a substantial pool of DOC. Intrasedimental ice (non-massive) like ice lenses and pore ice are another important part of unconsolidated permafrost deposits. DOC concentrations within intrasedimental ice differ in orders of magnitude compared to massive ice and rise up to 1200 mg/L. Although these numbers might be still small compared to the POC stocks in peat and mineral soils, DOC is chemically labile and may directly enter local food webs of the near-shore zone. Moreover, due to its lability, DOC is quickly mineralized and returned to the atmosphere when released due to permafrost degradation. Robust estimations of how much organic carbon is potentially released from permafrost are crucial for predicting the strength and timing of carbon-cycle feedback mechanisms in the Arctic. This approach shall lead to an improved understanding of how important permafrost thaw in general and the erosion of permafrost coasts in particular are for the climate development this century and beyond. This is especially important in the Arctic before the background of expected rising air and sea surface temperatures, prolongation of the open-water season, increasing storm frequency and accelerating eustatic sea level rise