Prevalência de infecções sexualmente transmissíveis em mulheres privadas de liberdade

The Infections Sexually Transmissible (IST), historically old, presents stay and they were added in the decade of 80, to the appearance of the epidemic of the aids and the hepatitis B. The private women of freedom constitute a vulnerable population to these offences and they are big the challenges for his/her enfrentamento. Due to that reality, he/she took place a descriptive research, of field, with quantitative approach, with the objective of verifying the prevalence of IST in private women of freedom, in Santarém, Pará. The sample is constituted of 65 handbooks. In agreement with the obtained results, 40% of the women live in stable union; 45% have incomplete fundamental teaching; 35% are between 18 and 24 years. As for the accomplishment of exams for the diagnosis of IST, 55% never accomplished and 36% present.O objetivo de verificar a prevalência de IST em mulheres privadas de liberdade, em Santarém, Pará. A amostra constitui-se de 65 prontuários. De acordo com os resultados obtidos, 40% das mulheres vivem em união estável; 45% têm ensino fundamental incompleto; 35% estão entre 18 e 24 anos.  Quanto à realização de exames para o diagnóstico de IST, 55% nunca realizou e 36% apresenta registro de um ou mais exames realizados. Desses, em 04 dos prontuários analisados haviam registros do diagnóstico de IST: 2 por sífilis, 1 por gonorreia e 1 por HIV. Os dados revelam que a prevalência de IST entre mulheres privadas de liberdade em Santarém, Pará é relevante e deve ser tratada com atenção e cautela, ressaltando que desenvolver ações preventivas, para identificação do diagnóstico e tratamento de forma planejada e integrada é essencial no contexto do sistema penitenciário brasileiro

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Equação de Cockcroft – GAULT (CG) e Clearence de Creatinina (CC) / Between Cockcroft – GAULT (CG) and Creatinine Clearence

Os rins têm importante função no organismo, pois esses são responsáveis pela filtração do sangue, sendo assim, eles retiram as substâncias tóxicas e os excessos que existem em nosso corpo. A insuficiência renal crônica é um dos exemplos de patologia que podem afetar a função renal, levando a complicações renais como perda progressiva e irreversível, considerada atualmente como um problema de Saúde Pública mundial. Se houver suspeita de Doença Renal Crônica, exames clínicos de triagem devem ser solicitados, como o de Elementos e Sedimentos Anormais (EAS), a dosagem sérica de creatinina e a uréia. Em caso de resultados com alterações, é solicitado o EAS 24 horas que determina o Clearence de Creatinina (CC) e a Taxa de Filtração Glomerular pelas equações. O objetivo da pesquisa foi correlacionar à equação de Cockcroft-Gault (CG) e o CC em resultados de exames. Esta pesquisa é caracterizada como descritiva, analítica, com abordagem quantitativa. Realizada por meio da análise de dados de pacientes atendidos e cadastrados no sistema de informação de um laboratório particular no município de Santarém, Estado do Pará, onde se obteve os seguintes resultados: O modelo de regressão de Deming mostrou uma correlação estatisticamente significativa onde o r = 0,505 entre o cleareance dosado e o estimado da equação de CG. A análise correta dos exames em concordância com a clínica do paciente é essencial para a obtenção de um diagnostico preciso e correto, para que assim se escolha a melhor intervenção e favoreça a qualidade de vida do paciente.AbstractThe kidney shave an important function in the organism. Therefore, they remove the toxic substances and excesses that exist in our body. The chronic renal failure is a pathology of examples that may affect renal function, leading to kidney complications as progressive and irreversible loss, currently considered as a public health problem worlwide, if there is suspicion of renal chronic disease, clinical exams must be requested, as the Abnormal Elements of the Sediments, the serum creatinine and urea. In case of alteration in results. The Abnormal Elements of the Sediments (AES) exam is requested 24 hours that determines the Creatinine Clearence (CC) and Glomerular Filtration Rate by equations. The objective of there search was to correlate the Crockcroft – Gault’s equation and CC in exams results. This research is characterized as descriptive, analytical, with a quantitative approach. Performed by analysis data met and patients registered in the information system of a private laboratory in the borough of Santarém, Pará estate, where the following results was obtained. Deming’s model showed a statistically significant correlations where r= 0,505 closed clearance between the CG and the estimated equation. The correct analysis of the exams in accordance with the patient’s clinical is essencial to obtain a accurate and correct diagnosis, so that you choose the best intervention and promotes the patient’s quality of life

Correction: Lesbon et al. Nucleocapsid (N) Gene Mutations of SARS-CoV-2 Can Affect Real-Time RT-PCR Diagnostic and Impact False-Negative Results. <i>Viruses</i> 2021, <i>13</i>, 2474

The authors hereby request the inclusion of two authors (Olivia Teixeira and Maria Cristina Nonato) in the recently published article in Viruses entitled “Nucleocapsid (N) gene mutations of SARS-CoV-2 can affect real-time RT-PCR diagnostic and impact false-negative results” [...