Forêts de montagne et changement climatique : impacts et adaptation

This review identifies the main impacts of climate change on mountain forests, mainly in Europe, and the management practices proposed for forest adaption. The rise in temperatures, more frequent droughts and the multiplication of extreme events should lead, especially below 1000m in altitude, to the disappearance of highly drought-intolerant tree species (spruce, Scots pine) and their replacement by deciduous trees. In addition, recruitment of some species (fir, beech) is observed at higher altitudes and the duration of the growing season is increasing. Management recommendations for forest adaptation to climate change focus on reducing tree species' vulnerability to water stress and pests, as well as increasing their resilience and ability to respond to extreme weather events. They require genetic improvements and practices that encourage the establishment of suitable species, reduce water consumption and reduce the exposure of stands to risk.Les impacts du changement climatique sur les forêts de montagne sont déjà perceptibles et les prévisions nous montrent, par leurs contradictions, la complexité des phénomènes en jeu. L'objectif de cette étude bibliographique est d'abord de caractériser les principaux effets du changement climatique, principalement dans les forêts alpines, puis de présenter différentes options d'adaptation devant permettre de conserver les services actuellement fournis par la forêt. L'épicéa, le sapin et le hêtre, dominants dans les Alpes françaises, y sont privilégiés

Forêts de montagne et changement climatique : impacts et adaptations

This review identifies the main impacts of climate change on mountain forests, mainly in Europe, and the management practices proposed for forest adaption. The rise in temperatures, more frequent droughts and the multiplication of extreme events should lead, especially below 1000m in altitude, to the disappearance of highly drought-intolerant tree species (spruce, Scots pine) and their replacement by deciduous trees. In addition, recruitment of some species (fir, beech) is observed at higher altitudes and the duration of the growing season is increasing. Management recommendations for forest adaptation to climate change focus on reducing tree species' vulnerability to water stress and pests, as well as increasing their resilience and ability to respond to extreme weather events. They require genetic improvements and practices that encourage the establishment of suitable species, reduce water consumption and reduce the exposure of stands to risk.Cette étude bibliographique recense les principaux impacts du changement climatique sur les forêts de montagne, principalement européennes, ainsi que les pratiques de gestion proposées pour adapter les forêts à ces changements. La hausse des températures, les sécheresses plus fréquentes et la multiplication des évènements extrêmes devraient entrainer, surtout en-deçà de 1000m d'altitude, une réduction des essences les moins tolérantes à la sécheresse (épicéa, pin sylvestre) et leur remplacement par des feuillus. D'ores et déjà, le recrutement de certaines essences (sapin, hêtre) est observé à des altitudes plus élevées et la durée de la saison de végétation augmente. Les préconisations de gestion pour l'adaptation des forêts au changement climatique s'attachent à réduire la vulnérabilité des essences au stress hydrique et aux parasites, ainsi qu'à renforcer leur résilience et leur capacité de réponse aux évènements climatiques extrêmes. Elles passent par des améliorations génétiques et des pratiques qui favorisent l'installation d'espèces adaptées, réduisent la consommation d'eau et l'exposition des peuplements aux risques

Re: "Comparison of antipseudomonal betalactams for febrile neutropenia empiric therapy: systematic review and network metaanalysis" by Horita et al

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Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

The aim of this work was to encapsulate transforming growth factor b1 (TGF-b1) into PLGA microparticles for regenerative medicine applications. TGF-b1 was firstly precipitated to ensure its stability during subsequent encapsulation within microparticles. A novel emulsification/extraction process in CO2 medium under mild conditions of pressure and temperature was used to encapsulate the protein. Interestingly, non-volatile injectable solvents, isosorbide dimethyl ether (DMI) and glycofurol (GF), were employed to precipitate the protein and to dissolve the polymer. Good encapsulation efficiency was obtained with preserved bioactivity of the protein. The microparticles were characterized in terms of size and zeta potential. In addition, the morphology and surface properties were determined using scanning electron microscopy (SEM) and atomic force microscopy (AFM) respectively. In vitro release study of the protein from microparticles was presented to assess the capacity of these systems to control the protein release. Moreover, cytotoxicity study was performed and showed an excellent cytocompatibility of the obtained microparticles. Thus, we described an effective and original process for TGF-b1 encapsulation into PLGA microparticles. The obtained polymeric carriers could be used in many biomedical applications and were more specifically developed for cartilage regeneration

The effects of financialisation and financial development on investment: Evidence from firm-level data in Europe

In this paper we estimate the effects of financialization on physical investment in selected western European countries using panel data based on the balance-sheets of publicly listed non-financial companies (NFCs) supplied by Worldscope for the period 1995-2015. We find robust evidence of an adverse effect of both financial payments (interests and dividends) and financial incomes on investment in fixed assets by the NFCs. This finding is robust for both the pool of all Western European firms and single country estimations. The negative impacts of financial incomes are non-linear with respect to the companies’ size: financial incomes crowd-out investment in large companies, and have a positive effect on the investment of only small, relatively more credit-constrained companies. Moreover, we find that a higher degree of financial development is associated with a stronger negative effect of financial incomes on companies’ investment. This finding challenges the common wisdom on ‘finance-growth nexus’. Our findings support the ‘financialization thesis’ that the increasing orientation of the non-financial sector towards financial activities is ultimately leading to lower physical investment, hence to stagnant or fragile growth, as well as long term stagnation in productivity

Volatile and glycosidically bound composition of Loureiro and Alvarinho wines

Composition of Loureiro and Alvarinho wines from the Vinhos Verdes region, respecting free volatile compounds as well as glycosidically bound aroma precursors, was exhaustively determined by GC-MS after adsorption on XAD-2 resin. On the whole, were identified and quantified 120 volatile compounds in the free fraction and 77 glycosidically bound compounds, belonging to C6-compounds, alcohols, fatty acids ethyl esters, esters of organic acids, acetates, monoterpenic alcohols, monoterpenic oxides and diols, C13-norisoprenoids, volatile phenols, volatile fatty acids and carbonyl compounds. Globally, the wines of the two cultivars present similar composition on volatiles. However, respecting varietal compounds, Loureiro wines are richer than Alvarinho ones with regard to C6-compounds and monoterpenic compounds, occurring the opposite for volatile phenols. It was also demonstrate that wines of both varieties may benefit the aroma reserve, present as glycoconjugates, as it is susceptible of being technologically explored. Linalool, Ho-trienol, α-terpineol, contributing with fruity and floral notes, and β-damascenone mostly for Alvarinho, confering tropical fruit notes, are the varietal compounds which may particularly influence the aroma of these wines. Respecting fermentative compounds, Alvarinho is also particularly rich in fatty acids ethyl esters related to lipid metabolism and acetates of fusel alcohols, which can provide it a fruity character; Loureiro contains higher levels of esters of organic acids and 2-phenylethanol, conferring fruity and floral notes. Sensory analysis agree with chemical analyses showing a pronounced tree and tropical fruit character for Alvarinho wines while Loureiro wines present more intense citrus fruit notes.Centre of Biological Engineering of Universidade do Minho; Estação Vitivinícola Amândio Galhano (EVAG); Solar de Serrade; EVAG; Comissão de Viticultura da Região dos Vinhos Verdes

Treatment for acute myelogenous leukemia by low dose Total Body Irradiation (TBI) based conditioning and hematopoietic cell transplantation from related and unrelated donors

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Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project

Quantitative information from magnetic resonance imaging (MRI) may substantiate clinical findings and provide additional insight into the mechanism of clinical interventions in therapeutic stroke trials. The PERFORM study is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke. We report on the design of an exploratory longitudinal MRI follow-up study that was performed in a subgroup of the PERFORM trial. An international multi-centre longitudinal follow-up MRI study was designed for different MR systems employing safety and efficacy readouts: new T2 lesions, new DWI lesions, whole brain volume change, hippocampal volume change, changes in tissue microstructure as depicted by mean diffusivity and fractional anisotropy, vessel patency on MR angiography, and the presence of and development of new microbleeds. A total of 1,056 patients (men and women ≥55 years) were included. The data analysis included 3D reformation, image registration of different contrasts, tissue segmentation, and automated lesion detection. This large international multi-centre study demonstrates how new MRI readouts can be used to provide key information on the evolution of cerebral tissue lesions and within the macrovasculature after atherothrombotic stroke in a large sample of patients