SELF-REPRESENTATION IN CHILDREN SUFFERING FROM CONGENITAL HEART DISEASE (CHD) AND MATERNAL COMPETENCE

Background: Child development may be subject to forms of motor, physical, cognitive and self-representation impairments when complex congenital heart disease (CHD) occurs. In some cases, inadequacy of both self-representation as well as the family system are displayed. It seems to be important to search the likely internal and external resources of the CHD child, and the possible connections among such resources, which may help him/her to manage his/her own risk condition. Design and Methods: The research project inquires the possible resources related to the self-representation and self-esteem levels of the CHD child, and those related to maternal self-perception as competent mothers. A group of 25 children (mean age=10,2; SD=1,8) suffering from specific forms of CHD, and a group made up of their relative mothers (mean age=38,2; SD=5) were studied. The tools used were the Human Figure Drawing, to investigate child body-related self-representation; the TMA scale (Self-esteem Multidimensional Test), to investigate the child’s self-esteem; and the Q-sort questionnaire, to assess how mothers perceived their maternal competence. Results: Data concerning the likely correlations between the child’s self-representation and the maternal role competence show [that] positive correlations between some indicators of maternal competence, specific aspects of CHD children’s self-representation (mothers’ emotional coping and children’s self-image adequacy) and self-esteem (mothers’ emotional scaffolding and children’s self-esteem at an emotional level). Conclusions: By detecting the occurrence of specific correlations among resources of both child and mother, the study provides cardiologists with information that is useful for building a relationship with the families concerned, which would seem to enhance the quality of the process of the cure itself

Southern-Tyrrhenian seismicity in space-time-magnitude domain

An analysis is conducted on a catalogue containing more than 2000 seismic events occurred in the southern Tyrrhenian Sea between 1988 and October 2002, as an attempt to characterise the main seismogenetic processes active in the area in space, time and magnitude domain by means of the parameters of phenomenological laws. We chose to adopt simple phenomenological models, since the low number of data did not allow to use more complex laws. The two main seismogenetic volumes present in the area were considered for the purpose of this work. The first includes a nearly homogeneous distribution of hypocentres in a NW steeply dipping layer as far as about 400 km depth. This is probably the seismological expression of the Ionian lithospheric slab subducting beneath the Calabrian Arc. The second contains hypocentres concentrated about a sub-horizontal plane lying atan average depth of about 10 km. It is characterised by a background seismicity spread all over the area and by clusters of events that generally show a direction of maximum elongation. The parameters of the models describing seismogenetically homogeneous subsets of the earthquake catalogue in the three analysis domains, along with their confidence intervals, are estimated and analysed to establish whether they can be regarded as representative of a particular subset

Double-blind placebo-controlled randomized clinical trial on the efficacy of Aerosal® in the treatment of sub-obstructive adenotonsillar hypertrophy and related diseases

n/

Quantitative phosphoproteomics reveals novel roles of cAMP in plants

3',5'-cyclic adenosine monophosphate (cAMP) is finally recognized as an essential signaling molecule in plants where cAMP-dependent processes include responses to hormones and environmental stimuli. To better understand the role of 3',5'-cAMP at the systems level, we have undertaken a phosphoproteomic analysis to elucidate the cAMP-dependent response of tobacco BY-2 cells. These cells overexpress a molecular "sponge" that buffers free intracellular cAMP level. The results show that, firstly, in vivo cAMP dampening profoundly affects the plant kinome and notably mitogen-activated protein kinases, receptor-like kinases, and calcium-dependent protein kinases, thereby modulating the cellular responses at the systems level. Secondly, buffering cAMP levels also affects mRNA processing through the modulation of the phosphorylation status of several RNA-binding proteins with roles in splicing, including many serine and arginine-rich proteins. Thirdly, cAMP-dependent phosphorylation targets appear to be conserved among plant species. Taken together, these findings are consistent with an ancient role of cAMP in mRNA processing and cellular programming and suggest that unperturbed cellular cAMP levels are essential for cellular homeostasis and signaling in plant cells