326 research outputs found
Seasonal variation in serum metabolites of northern European dogs
Background Metabolic profiling identifies seasonal variance of serum metabolites in humans. Despite the presence of seasonal disease patterns, no studies have assessed whether serum metabolites vary seasonally in dogs. Hypothesis There is seasonal variation in the serum metabolite profiles of healthy dogs. Animals Eighteen healthy, client-owned dogs. Methods A prospective cohort study. Serum metabolomic profiles were assessed monthly in 18 healthy dogs over a 12-month period. Metabolic profiling was conducted using a canine-specific proton nuclear magnetic resonance spectroscopy platform, and the effects of seasonality were studied for 98 metabolites using a cosinor model. Seasonal component was calculated, which describes the seasonal variation of each metabolite. Results We found no evidence of seasonal variation in 93 of 98 metabolites. Six metabolites had statistically significant seasonal variance, including cholesterol (mean 249 mg/dL [6.47 mmol/L] with a seasonal component amplitude of 9 mg/dL [0.23 mmol/L]; 95% confidence interval [CI] 6-13 mg/dL [0.14-0.33 mmol/L], P < .008), with a peak concentration of 264 mg/dL (6.83 mmol/L) in June and trough concentration of 236 mg/dL (6.12 mmol/L) in December. In contrast, there was a significantly lower concentration of lactate (mean 20 mg/dL [2.27 mmol/L] with a seasonal component amplitude of 4 mg/dL [0.42 mmol/L]; 95% CI 2-6 mg/dL [0.22-0.62 mmol/L], P < .001) during the summer months compared to the winter months, with a peak concentration of 26 mg/dL (2.9 mmol/L) in February and trough concentration of 14 mg/dL (1.57 mmol/L) in July. Conclusions and Clinical Importance We found no clear evidence that seasonal reference ranges need to be established for serum metabolites of dogs.Peer reviewe
Conformational Changes of the Flavivirus E Glycoprotein
Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10° rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27° between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses
First Constraints on Source Counts at 350 Microns
We have imaged a 6 arcminute region in the Bo\"otes Deep Field
using the 350 m-optimised second generation Submillimeter High Angular
Resolution Camera (SHARC II), achieving a peak 1 sensitivity of 5
mJy. We detect three sources above 3, and determine a spurious source
detection rate of 1.09 in our maps. In the absence of detections, we
rely on deep 24 m and 20 cm imaging to deduce which sources are most
likely to be genuine, giving two real sources. From this we derive an integral
source count of 0.84 sources arcmin at mJy,
which is consistent with 350 m source count models that have an
IR-luminous galaxy population evolving with redshift. We use these constraints
to consider the future for ground-based short-submillimetre surveys.Comment: accepted for publication in The Astrophysical Journa
Parsec-scale radio structures in the nuclei of four Seyfert galaxies
We present 18-cm radio maps of four Seyfert nuclei, Mrk 1, Mrk 3, Mrk 231 and
Mrk 463E, made with the European VLBI Network (EVN). Linear radio structures
are present in three out of four sources on scales of ~100 pc to ~1 kpc, and
the 20-mas beam of the EVN enables us to resolve details within the radio
structures on scales of <10 pc. Mrk 3 was also imaged using MERLIN and the data
combined with the EVN data to improve the sensitivity to extended emission. We
find an unresolved flat-spectrum core in Mrk 3, which we identify with the
hidden Seyfert 1 nucleus in this object, and we also see marked differences
between the two highly-collimated radio jets emanating from the core. The
western jet terminates in a bright hotspot and resembles an FRII radio
structure, whilst the eastern jet has more in common with an FRI source. In Mrk
463E, we use the radio and optical structure of the source to argue that the
true nucleus lies approximately 1 arcsec south of the position of the radio and
optical brightness peaks, which probably represent a hotspot at the working
surface of a radio jet. The EVN data also provide new evidence for a 100-pc
radio jet powering the radio source in the Type 1 nucleus of Mrk 231. However,
the Seyfert 2 galaxy Mrk 1 shows no evidence for radio jets down to the limits
of resolution (~10 pc). We discuss the range of radio source size and
morphology which can occur in the nuclei of Seyfert galaxies and the
implications for Seyfert unification schemes and for radio surveys of large
samples of objects.Comment: 23 pages, 7 postscript figures (supplied as separate files), uses AAS
aaspp4 LaTeX style file, to appear in the 10 June 1999 issue of The
Astrophysical Journa
Dichlorido(η6-p-cymene)(4-fluoroaniline-κN)ruthenium(II)
The title compound, [RuCl2(C10H14)(C6H6FN)], a pseudo-octahedral d
6 complex, has the expected piano-stool geometry around the Ru(II) atom. The fluoroaniline ring forms a dihedral angle of 19.3 (2)° with the p-cymene ring. In the crystal, two molecules form an inversion dimer via a pair of N—H⋯Cl hydrogen bonds. Weak intermolecular C—H⋯Cl interactions involving the p-cymene ring consolidate the crystal packing
Spatial distribution of podoconiosis in relation to environmental factors in Ethiopia: a historical review
BACKGROUND
An up-to-date and reliable map of podoconiosis is needed to design geographically targeted and cost-effective intervention in Ethiopia. Identifying the ecological correlates of the distribution of podoconiosis is the first step for distribution and risk maps. The objective of this study was to investigate the spatial distribution and ecological correlates of podoconiosis using historical and contemporary survey data.
METHODS
Data on the observed prevalence of podoconiosis were abstracted from published and unpublished literature into a standardized database, according to strict inclusion and exclusion criteria. In total, 10 studies conducted between 1969 and 2012 were included, and data were available for 401,674 individuals older than 15 years of age from 229 locations. A range of high resolution environmental factors were investigated to determine their association with podoconiosis prevalence, using logistic regression.
RESULTS
The prevalence of podoconiosis in Ethiopia was estimated at 3.4% (95% CI 3.3%-3.4%) with marked regional variation. We identified significant associations between mean annual Land Surface Temperature (LST), mean annual precipitation, topography of the land and fine soil texture and high prevalence of podoconiosis. The derived maps indicate both widespread occurrence of podoconiosis and a marked variability in prevalence of podoconiosis, with prevalence typically highest at altitudes >1500 m above sea level (masl), with >1500 mm annual rainfall and mean annual LST of 19-21°C. No (or very little) podoconiosis occurred at altitudes 24°C.
CONCLUSION
Podoconiosis remains a public health problem in Ethiopia over considerable areas of the country, but exhibits marked geographical variation associated in part with key environmental factors. This is work in progress and the results presented here will be refined in future work
The SCUBA Bright Quasar Survey (SBQS): 850micron observations of the z>4 sample
We present initial results of a new, systematic search for massive
star-formation in the host galaxies of the most luminous and probably most
massive z>=4 radio-quiet quasars (M(B) 10^13Lsun).
A total of 38 z>=4 radio-quiet quasars have been observed at the JCMT using
SCUBA at 850microns: 8 were detected (>3sigma) with S(850microns)>~ 10mJy
(submillimetre-loud). The new detections almost triple the number of optically
selected, submillimetre-loud z>~4 radio-quiet quasars known to date. We include
a detailed description of how our quasar sample is defined in terms of radio
and optical properties.
There is no strong evidence for trends in either detectability or 850microns
flux with absolute magnitude, M(B). We find that the weighted mean flux of the
undetected sources is 2.0 +/- 0.6mJy, consistent with an earlier estimate of
\~3mJy based on more sensitive observations of a sample z>~4 radio-quiet
quasars (McMahon et al., 1999). This corresponds to an inferred starformation
rate of \~1000Msun/yr, similar to Arp220. The typical starformation timescale
for the submillimetre-bright sources is ~1Gyr, 10 times longer than the typical
accretion-driven e-folding timescale of ~5x10^7 years. Our 850micron detection
of the z=4.4 quasar PSS J1048+4407 when analysed in conjunction with 1.2mm
single-dish and interferometric observations suggests that this source is
resolved on angular scales of 1-2" (6-12 kpc). In addition, we present a new
optical spectrum of this source, identifying it as a broad absorption line
(BAL) quasar. The new redshift is outside that covered in a recent CO line
search by Guilloteau et al., (1999), highlighting the need for accurate
redshifts for the obervation and interpretation of high-redshift line studies.Comment: 16 pages, 11 figures. Accepted by Monthly Notices of the Royal
Astronomical Societ
Bayesian mapping of pulmonary tuberculosis in Antananarivo, Madagascar
<p>Abstract</p> <p>Background</p> <p>Tuberculosis (TB), an infectious disease caused by the <it>Mycobacterium tuberculosis </it>is endemic in Madagascar. The capital, Antananarivo is the most seriously affected area. TB had a non-random spatial distribution in this setting, with clustering in the poorer areas. The aim of this study was to explore this pattern further by a Bayesian approach, and to measure the associations between the spatial variation of TB risk and national control program indicators for all neighbourhoods.</p> <p>Methods</p> <p>Combination of a Bayesian approach and a generalized linear mixed model (GLMM) was developed to produce smooth risk maps of TB and to model relationships between TB new cases and national TB control program indicators. The TB new cases were collected from records of the 16 Tuberculosis Diagnostic and Treatment Centres (DTC) of the city from 2004 to 2006. And five TB indicators were considered in the analysis: number of cases undergoing retreatment, number of patients with treatment failure and those suffering relapse after the completion of treatment, number of households with more than one case, number of patients lost to follow-up, and proximity to a DTC.</p> <p>Results</p> <p>In Antananarivo, 43.23% of the neighbourhoods had a standardized incidence ratio (SIR) above 1, of which 19.28% with a TB risk significantly higher than the average. Identified high TB risk areas were clustered and the distribution of TB was found to be associated mainly with the number of patients lost to follow-up (SIR: 1.10, CI 95%: 1.02-1.19) and the number of households with more than one case (SIR: 1.13, CI 95%: 1.03-1.24).</p> <p>Conclusion</p> <p>The spatial pattern of TB in Antananarivo and the contribution of national control program indicators to this pattern highlight the importance of the data recorded in the TB registry and the use of spatial approaches for assessing the epidemiological situation for TB. Including these variables into the model increases the reproducibility, as these data are already available for individual DTCs. These findings may also be useful for guiding decisions related to disease control strategies.</p
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