701 research outputs found
Kalb-Ramond excitations in a thick-brane scenario with dilaton
We compute the full spectrum and eigenstates of the Kalb-Ramond field in a
warped non-compact Randall-Sundrum -type five-dimensional spacetime in which
the ordinary four-dimensional braneworld is represented by a sine-Gordon
soliton. This 3-brane solution is fully consistent with both the warped
gravitational field and bulk dilaton configurations. In such a background we
embed a bulk antisymmetric tensor field and obtain, after reduction, an
infinite tower of normalizable Kaluza-Klein massive components along with a
zero-mode. The low lying mass eigenstates of the Kalb-Ramond field may be
related to the axion pseudoscalar. This yields phenomenological implications on
the space of parameters, particularly on the dilaton coupling constant. Both
analytical and numerical results are given.Comment: 10 pages, 13 figures, and 2 tables. Final version to appear in The
European Physical Journal
Long-lived oscillons from asymmetric bubbles
The possibility that extremely long-lived, time-dependent, and localized
field configurations (``oscillons'') arise during the collapse of asymmetrical
bubbles in 2+1 dimensional phi^4 models is investigated. It is found that
oscillons can develop from a large spectrum of elliptically deformed bubbles.
Moreover, we provide numerical evidence that such oscillons are: a) circularly
symmetric; and b) linearly stable against small arbitrary radial and angular
perturbations. The latter is based on a dynamical approach designed to
investigate the stability of nonintegrable time-dependent configurations that
is capable of probing slowly-growing instabilities not seen through the usual
``spectral'' method.Comment: RevTeX 4, 9 pages, 11 figures. Revised version with a new approach to
stability. Accepted to Phys. Rev.
A hepatitis C virus DNA vaccine encoding a secreted, oligomerized form of envelope proteins is highly immunogenic and elicits neutralizing antibodies in vaccinated mice
Hepatitis C virus (HCV) persistently infects approximately 71 million people globally. To prevent infection a vaccine which elicits neutralizing antibodies against the virus envelope proteins (E1/E2) which are required for entry into host cells is desirable. DNA vaccines are cost-effective to manufacture globally and despite recent landmark studies highlighting the therapeutic efficacy of DNA vaccines in humans against cervical cancer, DNA vaccines encoding E1/E2 developed thus far are poorly immunogenic. We now report a novel and highly immunogenic DNA vaccination strategy that incorporates secreted E1 and E2 (sE1 and sE2) into oligomers by fusion with the oligomerization domain of the C4b-binding protein, IMX313P. The FDA approved plasmid, pVax, was used to encode sE1, sE2, or sE1E2 with or without IMX313P, and intradermal prime-boost vaccination studies in BALB/c mice showed that vaccines encoding IMX313P were the most effective in eliciting humoral and cell-mediated immunity against the envelope proteins. Further boosting with recombinant E1E2 proteins but not DNA nor virus-like particles (VLPs) expressing E1E2 increased the immunogenicity of the DNA prime-boost regimen. Nevertheless, the antibodies generated by the homologous DNA prime-boost vaccinations more effectively inhibited the binding of VLPs to target cells and neutralized transduction with HCV pseudoparticles (HCVpp) derived from different genotypes including genotypes 1, 2, 3, 4, 5, and 6. This report provides the first evidence that IMX313P can be used as an adjuvant for E1/E2-based DNA vaccines and represents a translatable approach for the development of a HCV DNA vaccine.Makutiro Ghislain Masavuli, Danushka K. Wijesundara, Alexander Underwood, Dale Christiansen, Linda Earnest-Silveira, Rowena Bull, Joseph Torresi, Eric J. Gowans and Branka Grubor-Bau
The New Physics at RHIC. From Transparency to High p Suppression
Heavy ion collisions at RHIC energies (Au+Au collisions at
GeV) exhibit significant new features as compared to
earlier experiments at lower energies. The reaction is characterized by a high
degree of transparency of the collisions partners leading to the formation of a
baryon-poor central region. In this zone, particle production occurs mainly
from the stretching of the color field. The initial energy density is well
above the one considered necessary for the formation of the Quark Gluon Plasma,
QGP. The production of charged particles of various masses is consistent with
chemical and thermal equilibrium. Recently, a suppression of the high
transverse momentum component of hadron spectra has been observed in central
Au+Au collisions. This can be explained by the energy loss experienced by
leading partons in a medium with a high density of unscreened color charges. In
contrast, such high jets are not suppressed in d+Au collisions suggesting
that the high suppression is not due to initial state effects in the
ultrarelativistic colliding nuclei.Comment: 15 pages, 11 figures. to appear in Nucl. Physics A. Invited talk at
'Nucleus-Nucleus Collisions 2003' conference, Mosco
The asymmetry of the proton in a Pion Cloud Model approach
We study the asymmetry of the proton in a model approach
in which hadronic fluctuations of the nucleon are generated through gluon
splitting and recombination mechanisms. Within this framework, it is shown that
the
asymmetry of the proton is consistently described by including only
nucleon fluctuations to and bound states. Predictions
of the model closely agree with the recent experimental data of the E866/NuSea
Collaboration.Comment: Final version. To appear in Phys. Rev.
Centrality dependence of charged-particle pseudorapidity distributions from d+Au collisions at sqrt(s_{NN})=200 GeV
Charged-particle pseudorapidity densities are presented for the d+Au reaction
at sqrt{s_{NN}}=200 GeV with -4.2 <= eta <= 4.2$. The results, from the BRAHMS
experiment at RHIC, are shown for minimum-bias events and 0-30%, 30-60%, and
60-80% centrality classes. Models incorporating both soft physics and hard,
perturbative QCD-based scattering physics agree well with the experimental
results. The data do not support predictions based on strong-coupling,
semi-classical QCD. In the deuteron-fragmentation region the central 200 GeV
data show behavior similar to full-overlap d+Au results at sqrt{s_{NN}}=19.4
GeV.Comment: 4 pages, 3figures; expanded discussion of uncertainties; added 60-80%
centrality range; added additional discussion on centrality selection bia
Scanning the phases of QCD with BRAHMS
BRAHMS has the ability to study relativistic heavy ion collisions from the
final freeze-out of hadrons all the way back to the initial wave-function of
the gold nuclei. This is accomplished by studying hadrons with a very wide
range of momenta and angles. In doing so we can scan various phases of QCD,
from a hadron gas, to a quark gluon plasma and perhaps to a color glass
condensate.Comment: 8 pages, 6 figures, proceedings of plenary talk at Quark Matter 2004
conferenc
High Pt Hadron Spectra at High Rapidity
We report the measurement of charged hadron production at different
pseudo-rapidity values in deuteron+gold as well as proton+proton collisions at
= 200GeV at RHIC. The nuclear modification factors and
are used to investigate new behaviors in the deuteron+gold system as
function of rapidity and the centrality of the collisions respectively.Comment: Nine pages 4 figures to be published in the QM2004 Proceedings, typos
corrected and one reference adde
Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery
The introduction of directly acting antiviral agents (DAAs) has produced significant improvements in the ability to cure chronic hepatitis C infection. However, with over 2% of the world's population infected with HCV, complications arising from the development of cirrhosis of the liver, chronic hepatitis C infection remains the leading indication for liver transplantation. Several modelling studies have indicated that DAAs alone will not be sufficient to eliminate HCV, but if combined with an effective vaccine this regimen would provide a significant advance towards achieving this critical World Health Organisation goal. We have previously generated a genotype 1a, 1b, 2a, 3a HCV virus like particle (VLP) quadrivalent vaccine. The HCV VLPs contain the core and envelope proteins (E1 and E2) of HCV and the vaccine has been shown to produce broad humoral and T cell immune responses following vaccination of mice. In this report we further advanced this work by investigating vaccine responses in a large animal model. We demonstrate that intradermal microneedle vaccination of pigs with our quadrivalent HCV VLP based vaccine produces long-lived multi-genotype specific and neutralizing antibody (NAb) responses together with strong T cell and granzyme B responses and normal Th1 and Th2 cytokine responses. These responses were achieved without the addition of adjuvant. Our study demonstrates that our vaccine is able to produce broad immune responses in a large animal that, next to primates, is the closest animal model to humans. Our results are important as they show that the vaccine can produce robust immune responses in a large animal model before progressing the vaccine to human trials.D. Christiansen, L. Earnest-Silveira, B. Grubor-Bauk, D. K. Wijesundara, I. Boo, P. A. Ramsland, E. Vincan, H. E. Drummer, E. J. Gowans and J. Torres
Charged particle densities from Au+Au collisions at sqrt{s_{NN}}=130 GeV
We present charged particle densities as a function of pseudorapidity and
collision centrality for the 197Au+197Au reaction at sqrt{s_{NN}}=130 GeV. An
integral charged particle multiplicity of 3860+/-300 is found for the 5% most
central events within the pseudorapidity range -4.7 <= eta <= 4.7. At
mid-rapidity an enhancement in the particle yields per participant nucleon pair
is observed for central events. Near to the beam rapidity, a scaling of the
particle yields consistent with the ``limiting fragmentation'' picture is
observed. Our results are compared to other recent experimental and theoretical
discussions of charged particle densities in ultra-relativistic heavy-ion
collisions.Comment: 14 pages, 4 figures; to be published in Phys. Lett.
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