Juvenile myelomonocytic leukemia (JMML)

Review on juvenile myelomonocytic leukemia, with data on clinics, pathology, and involved genes

Infant leukaemias,Congenital leukaemias,Neonatal leukaemias

Review on congenital/neonatal and infant leukemias, with data on clinics, pathology, and involved genes

Fabrication and application of short and novel structure in-fibre Bragg gratings

This thesis presents details on progress made in the fabrication and application of short and novel structure fibre Bragg gratings. The basic theoretical concepts of in-fibre Bragg gratings and photosensitive mechanisms are introduced together with an overview of fabrication methods and applications presented to date. The fabrication of fibre Bragg gratings using a quadrupled Nd:YAG laser is presented and some of the issues of grating fabrication using a fabrication using a phasemask are investigated, including the variation of the separation of the fibre and phasemask, and other alignment issues. A new apodisation technique is presented, enabling the production of gratings with a wide range of spectral profiles. The technique is used to investigate the design and fabrication of length limited fibre Bragg gratings for use in telecommunication systems as filters. Application to devices designed for use in WDM systems is presented. The use of fibre Bragg gratings as high spatial resolution distributed sensors is investigated. Grating sensing arrays comprising very short apodised gratings are demonstrated and Chirped Moiré gratings are implemented as distributed sensors achieving high spatial resolution with miniature point sensing sub-elements. A novel grating sensing element designed to imitate an interferometer is also presented. Finally, the behaviour of gratings fabricated in Boron-Germania-co-doped fibre is investigated, revealing atypical behaviour of the Bragg wavelength during ageing

Systemic EBV-positive T-cell lymphoma of childhood

Review on systemic EBV positive T-cell lymphoma of childhood, with data on clinical findings, pathology and genetic alterations

Are medical educators following General Medical Council guidelines on obesity education: if not why not?

BackgroundAlthough the United Kingdom's (UK's) General Medical Council (GMC) recommends that graduating medical students are competent to discuss obesity and behaviour change with patients, it is difficult to integrate this education into existing curricula, and clinicians report being unprepared to support patients needing obesity management in practice. We therefore aimed to identify factors influencing the integration of obesity management education within medical schools.MethodsTwenty-seven UK and Irish medical school educators participated in semi-structured interviews. Grounded theory principles informed data collection and analysis. Themes emerging directly from the dataset illustrated key challenges for educators and informed several suggested solutions.ResultsFactors influencing obesity management education included: 1) Diverse and opportunistic learning and teaching, 2) Variable support for including obesity education within undergraduate medical programmes, and 3) Student engagement in obesity management education. Findings suggest several practical solutions to identified challenges including clarifying recommended educational agendas; improving access to content-specific guidelines; and implementing student engagement strategies.ConclusionsStudents' educational experiences differ due to diverse interpretations of GMC guidelines, educators' perceptions of available support for, and student interest in obesity management education. Findings inform the development of potential solutions to these challenges which may be tested further empirically

Myeloid proliferations in Down syndrome

Review on myeloid proliferations related to Down syndrome, with data on clinics, pathology, and involved genes

Myeloid sarcoma

Review on myeloid sarcoma, with data on clinics, pathology, and involved genes

Acute lymphoblastic leukemia in Down syndrome

Review on acute lymphoblastic leukemia in Down syndrome, with data on clinics, pathology, and involved genes

Down syndrome

Review on Down syndrome, with data on clinics, susceptibility to neoplasms, and the genes involve

Cutaneous mastocytosis

Review on cutaneous mastocytosis, with data on clinics, pathology, and involved genes