The Suggestibility of Older Witnesses

The present study compares younger and older adult witnesses’ susceptibility to misinformation. Previous research on the misinformation effect has not measured the relationship between the effect and individuals’ perceptions of their own memory abilities. Such perceptions, and general knowledge of one’s own memory processes, are referred to as “metamemory.” In order to examine the relationship between metamemory and the misinformation effect in the present study, participants also completed a questionnaire that assessed their perception of their memory functioning. Although older persons tend to perceive their memories as being faulty, the correlation between self-assessment of memory abilities and actual memory performance is relatively low (Zelinski, Gilewski, & Thompson, 1980). We therefore predicted that there would be a negligible relationship between participants’ self-assessed memory functioning and whether or not they were susceptible to misinformation, for both younger and older adults

Predictors of ADL Disability in Culturally Diverse Older Adults

The purpose of this study was to utilize the disablement pathway model to examine the contribution of physical function, dyspnea, and pain to disability in activities-of-daily-living (ADL) in culturally diverse older adults. Participants were 51 older adults (age = 69.0 years ± 9.7; 76.5% African-American, 51.0% \u3c high school education, 52.9% \u3c $20,000 annual income) from an urban community center and an independent living housing facility for seniors. Participants completed the Functional Status Index (FSI), which provides ratings of need for assistance (FSIA) and pain (FSIP) with ADL, the Continuous Scale Physical Functional Performance 10-item Test (CS-PFP10), and an analog dyspnea scale. Hierarchical multiple regression analyses revealed that facility, physical function, pain, and dyspnea accounted for 50.5% of the variance in disability and that pain (β = .43, p \u3c .01) and physical function (β = -.39, p \u3c .01) were the only significant predictors. In the second model, facility, dyspnea, and pain explained 27.6% of the variance in physical function, and facility (β = .39, p \u3c .01) and dyspnea (β = -.26, p = .05) were the only significant predictors. Based on the disablement pathway model, physical functional improvement and pain prevention and management should be targeted when designing culturally appropriate strategies for delaying disability and maintaining independent life

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

The search for longevity-determining genes in human has largely neglected the operation of genetic interactions. We have identified a novel combination of common variants of three genes that has a marked association with human lifespan and healthy aging. Subjects were recruited and stratified according to their genetically inferred ethnic affiliation to account for population structure. Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity. An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population. A profile of healthy aging was developed using a deficit accumulation index, which showed that this combination of gene variants is associated with healthy aging. The variation in LASS1 is functional, causing enhanced expression of the gene, and it contributes to healthy aging and greater survival in the tenth decade of life. Thus, rare gene variants need not be invoked to explain complex traits such as aging; instead rare congruence of common gene variants readily fulfills this role. The interaction between the three genes described here suggests new models for cellular and molecular mechanisms underlying exceptional survival and healthy aging that involve lipotoxicity. © 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland

Longitudinal assessment of cognitive and psychosocial functioning after Hurricanes Katrina and Rita: Exploring disaster impact on middle-aged, older, and oldest-old adults

The authors examined the effects of Hurricanes Katrina and Rita on cognitive and psychosocial functioning in a lifespan sample of adults 6-14 months after the storms. Participants were recruited from the Louisiana Healthy Aging Study. Most were assessed during the immediate impact period and retested for this study. Analyses of pre- and post-disaster cognitive data confirmed that storm-related decrements in working memory for middle-aged and older adults observed in the immediate impact period had returned to pre-hurricane levels in the post-disaster recovery period. Middle-aged adults reported more storm-related stressors and greater levels of stress than the two older groups at both waves of testing. These results are consistent with a burden perspective on post-disaster psychological reactions. © 2012 Wiley Periodicals, Inc

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

Funder: Addenbrooke's Charitable Trust, Cambridge University Hospitals; FundRef: http://dx.doi.org/10.13039/501100002927Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin pathway activation and its key pattern recognition molecule MBL in COVID-19 is still not fully understood.MethodsWe therefore investigated activation of the lectin pathway in two independent cohorts of SARS-CoV-2 infected patients, while also analysing MBL protein levels and potential effects of the six major single nucleotide polymorphisms (SNPs) found in the MBL2 gene on COVID-19 severity and outcome.ResultsWe show that the lectin pathway is activated in acute COVID-19, indicated by the correlation between complement activation product levels of the MASP-1/C1-INH complex (p=0.0011) and C4d (p<0.0001) and COVID-19 severity. Despite this, genetic variations in MBL2 are not associated with susceptibility to SARS-CoV-2 infection or disease outcomes such as mortality and the development of Long COVID.ConclusionIn conclusion, activation of the MBL-LP only plays a minor role in COVID-19 pathogenesis, since no clinically meaningful, consistent associations with disease outcomes were noted

Intersection of Trauma and Disaster Behavioral Health

This contributed volume examines the intersection of trauma and disaster behavioral health from a lifespan perspective, filling a critical gap in the literature on disaster mental health research. In the chapters, the contributors evaluate behavioral data of adults exposed to various environmental events in both the United States (i.e., the 2017 Hurricanes Irma in Florida and Harvey in Houston) and abroad (i.e., missile fire in the 2014 Israel-Gaza conflict). Contributors also suggest future directions, practices, and policies for trauma and disaster response. The three parts of the book provide an overview of disaster behavioral health across the lifespan, propose practical applications of research theories to psychosocial problems resulting from disasters and trauma, and evaluate disaster and trauma interventions from a macro-level perspective. Topics explored among the chapters include: Integrating Trauma-Informed Principles into Disaster Behavioral Health Targeting Older Adults Cultural Competence and Disaster Mental Health When Disasters Strike: Navigating the Challenges of Sudden Science Frameworks of Recovery: Health Caught at the Intersection of Housing, Education, and Employment Opportunities After Hurricane Katrina Substance Use Issues and Behavioral Health After a Disaster Psychosocial Recovery After Natural Disaster: International Advocacy, Policy, and Recommendations The Intersection of Trauma and Disaster Behavioral Health is a vital resource for researchers whose expertise covers the domains of trauma, health and wellness, and natural and technological disasters. The book also is a useful supplement to graduate courses in psychology, sociology, social work, disaster science, human ecology, and public health.https://repository.lsu.edu/facultybooks/1291/thumbnail.jp

The Other Side of Suffering: Finding a Path to Peace After Tragedy

In this work, the author addresses a perennial question: how does someone recover from a catastrophic disaster or other personal tragedy? The answer, she suggests, may come from coastal residents who survived the 2005 Hurricanes Katrina and Rita. These survivors endured a long and painfuljourney after losing homes and communities in these deadly storms, and their experiences provide an authentic and relatable example for other people who must overcome a life changing tragedy.The Other Side of Suffering is based on behavioral research conducted by the author in the years after the hurricanes. In her research, Katie Cherry logged thousands of miles crisscrossing the Louisiana coastline and spoke with over 190 current and former coastal residents with catastrophic lossesafter Katrina. The author begins with an overview of the human impact of these disasters, and then focuses on the community impact on two coastal parishes in southern Louisiana. The incorporation of the personal journal entries of a Katrina survivor provides an intimate glimpse into the long daysand months that over a million displaced Gulf Coast residences experienced. From this research, the author identifies six evidence-based principles of healing: faith and humor, respect and gratitude, and acceptance and silver linings. Colorful illustrations and direct quotes from the respondents bring these principles to life. Along with a path to healing, the book also discusses grief and the new normal after a disaster, as well as obstacles that may thwart the healing process. Ultimately, the work emphasizes the importance of recovering daily routines and observances as life goes on after disaster.https://repository.lsu.edu/facultybooks/1328/thumbnail.jp

Lifespan Perspectives on Natural Disasters: Coping with Katrina, Rita, and Other Storms

Some of our most disturbing images of Hurricane Katrina involve the very old, trapped in flooded nursing homes, and the very young, sick in toxic trailers. Using the Katrina-Rita nexus as its reference point, Lifespan Perspectives on Natural Disasters takes the developmental long view on human strengths and vulnerabilities during large-scale devastation and crisis. An expert panel of behavioral scientists and first responders analyzes the psychological impact of natural disasters on--and coping faculties associated with--children, adolescents, and young, middle-aged, older, young-old and late-life oldest-old adults. This timely information is invaluable both to mental health service providers and to those tasked with developing age-appropriate disaster preparedness, intervention, and recovery programs. In addition, the book references other deadly storms as well as other major catastrophic events (e.g., the September 11 attacks, the Indian Ocean Tsunami), and includes such topics as: Young children\u27s understanding of hurricanes. Positive adjustment in youth after Katrina. How families make meaning out of disaster. Disaster recovery in the workplace. Recovery services for the frail elderly. Coping and health in late life. Preparation and training mental health personnel for disasters. Unique in the disaster literature, Lifespan Perspectives on Natural Disasters serves as a research reference and idea book for professionals and graduate-level students in psychology, social work, and disaster preparedness and services.https://repository.lsu.edu/facultybooks/1391/thumbnail.jp