8,253 research outputs found
In vitro antioxidant properties of polysaccharides from Armillaria mellea in batch fermentation
Antioxidant properties of exopolysaccharides (EPS) and intracellular polysaccharides (IPS) obtained respectively from mycelia and filtrates of submerged culture by Armillaria mellea in a 20-L stirred tank bioreactor were investigated. Effective production of EPS and IPS is available by submerged culture of A. mellea with respective number average molecular weights and protein/polysaccharide ratios as 7.68Ă106 Da and 7.68% as well as 5.65Ă106 Da and 5.26%. Both EPS and IPS exhibit powerful antioxidant activities by conjugated diene method, chelating effect on ferrous ions and scavenging effect on superoxide anion, as evidenced by their quite low EC50 values (< 5 mg/mL). Results confirmed that fermented A. mellea polysaccharides are potential antioxidant sources of both healthy medicine and food industries.Key words: Armillaria mellea, intracellular polysaccharide, exopolysaccharide, antioxidant activity
Ofatumumab and high-dose methylprednisolone for the treatment of patients with relapsed or refractory chronic lymphocytic leukemia.
Ofatumumab is a humanized anti-CD20 monoclonal antibody that has been approved by the FDA for the treatment of patients with chronic lymphocytic leukemia. We conducted a phase II single-arm study at a single center. Patients received ofatumumab (300 mg then 1000 mg weekly for 12 weeks) and methylprednisolone (1000 mg/m(2) for 3 days of each 28-day cycle). Twenty-one patients enrolled, including 29% with unfavorable cytogenetics (del17p or del11q). Ninety percent of patients received the full course without dose reductions or delays. The overall response rate was 81% (17/21) with 5% complete response, 10% nodular partial response, 67% partial response, 14% stable disease and 5% progressive disease. After a median follow-up of 31 months, the median progression-free survival was 9.9 months and the median time to next treatment was 12.1 months. The median overall survival has not yet been reached. The combination of high-dose methylprednisolone and ofatumumab is an effective and tolerable treatment regimen. This regimen may be useful for patients who are unable to tolerate more aggressive therapies, or have not responded to other treatments
Inactivation of hypoxia inducible factor (HIF) 1 alpha induces obesity-associated metabolic disorders through brown adipose tissue dysfunction
published_or_final_versionThe 14th Medical Research Conference, Hong Kong, 10 January 2009. In Hong Kong Medical Journal, 2009, v. 15, suppl. 1, p. 40, article no. 6
IDO1 (indoleamine 2,3-dioxygenase 1)
Review on IDO1 (indoleamine 2,3-dioxygenase 1), with data on DNA, on the protein encoded, and where the gene is implicated
IDO2 (indoleamine 2,3-dioxygenase 2)
Review on IDO2 (indoleamine 2,3-dioxygenase 2), with data on DNA, on the protein encoded, and where the gene is implicated
Cardiac-Specific Disruption of Bin1 in Mice Enables a Model of Stress- and Age-Associated Dilated Cardiomyopathy
Spin State Disproportionation in Insulating Ferromagnetic LaCoO3 Epitaxial Thin Films
The origin of insulating ferromagnetism in epitaxial LaCoO3 films under
tensile strain remains elusive despite extensive research efforts have been
devoted. Surprisingly, the spin state of its Co ions, the main parameter of its
ferromagnetism, is still to be determined. Here, we have systematically
investigated the spin state in epitaxial LaCoO3 thin films to clarify the
mechanism of strain induced ferromagnetism using element-specific x-ray
absorption spectroscopy and dichroism. Combining with the configuration
interaction cluster calculations, we unambiguously demonstrate that Co3+ in
LaCoO3 films under compressive strain (on LaAlO3 substrate) are practically a
low spin state, whereas Co3+ in LaCoO3 films under tensile strain (on SrTiO3
substrate) have mixed high spin and low spin states with a ratio close to 1:3.
From the identification of this spin state ratio, we infer that the dark strips
observed by high-resolution scanning transmission electron microscopy indicate
the position of Co3+ high spin state, i.e., an observation of a spin state
disproportionation in tensile-strained LaCoO3 films. This consequently explains
the nature of ferromagnetism in LaCoO3 films
6G White Paper on Machine Learning in Wireless Communication Networks
The focus of this white paper is on machine learning (ML) in wireless
communications. 6G wireless communication networks will be the backbone of the
digital transformation of societies by providing ubiquitous, reliable, and
near-instant wireless connectivity for humans and machines. Recent advances in
ML research has led enable a wide range of novel technologies such as
self-driving vehicles and voice assistants. Such innovation is possible as a
result of the availability of advanced ML models, large datasets, and high
computational power. On the other hand, the ever-increasing demand for
connectivity will require a lot of innovation in 6G wireless networks, and ML
tools will play a major role in solving problems in the wireless domain. In
this paper, we provide an overview of the vision of how ML will impact the
wireless communication systems. We first give an overview of the ML methods
that have the highest potential to be used in wireless networks. Then, we
discuss the problems that can be solved by using ML in various layers of the
network such as the physical layer, medium access layer, and application layer.
Zero-touch optimization of wireless networks using ML is another interesting
aspect that is discussed in this paper. Finally, at the end of each section,
important research questions that the section aims to answer are presented
- âŠ