1,142 research outputs found
Means or meaning: the logic of Paulâs rhetoric in Galatians 3:10-14
Gal. 3:10-14 is still one of the most controversial and challenging passages in Paul's letters. The logic of Paul's rhetoric is that which mainly baffles. Study of this text has been hampered by an inadequate appreciation of the ranges of possible meanings, at all semantic levels. We seek to redress this lack m chapter 2. We survey the science of logic. We discover overlooked semantic possibilities for three key word-groups in Paul's rhetoric. and could be "discourse" lexical concepts. By Paul very possibly intends "accomplishments" rather than "endeavour." Chapter 3 finds the indicated senses Paulâs. Effectively multiplying our data via sociolinguistic cognizance that identical words may denote different "realities" for speaker and hearer, we discover that Paul's usage implies a three-fold working semantic hypothesis: For Paul "faith" believes in a covenantal condition besides itself, namely obedience (endeavour to fulfil God's commands); Paul is basically denying that justification depends upon any particular amount of accomplishment of Godâs commands; and the issue Paul is addressing is not that of die true means of justification, but that of the true meaning of ("righteousness" and thereby of) "justification" in the context of Godâs covenant. The remainder of the thesis confirms and elaborates this overall meaning for Gal. 3:10-14. In verse 10 Paul points out that logically those who hold to the theory of "justification" have circumstances which contradict that theory; thus he is arguing by a "circumstantial" ad hominem type of argument. In verses 11-12 he circumstantially undermines his opponents' "accomplishments" righteousness-criterion by its incompatibility with Hab. 2:4. In verses 13-14, the "rescue" works entirely by causa cognoscendi: it is not a means of propitiation or repayment, either for man or for God. Our findings support our hypothesis
Modeling Energy Savings from Urban Shade Trees: An Assessment of the CITYgreen Energy Conservation Module
CITYgreen software has become a commonly used tool to quantify the benefits of urban shade trees. Despite its frequent use, little research has been conducted to validate results of the CITYgreen energy conservation module. The first objective of this study is to perform a familiar application of CITYgreen software to predict the potential energy savings contribution of existing tree canopies in residential neighborhoods during peak cooling summer months. Unlike previous studies utilizing CITYgreen, this study also seeks to assess the software\u27s performance by comparing model results (i.e., predicted energy savings) with actual savings (i.e., savings derived directly from energy consumption data provided by the electric utility provider). Homeowners in an older neighborhood with established trees were found to use less energy for air-conditioning than homeowners in a recently developed site. Results from the assessment of model performance indicated that CITYgreen more accurately estimated the energy savings in the highly vegetated, older neighborhood
Improving Agricultural Irrigation on the Balkhab River, Afghanistan
In Afghanistan, where 80% of the population is rural, irrigated agriculture is important for satisfying subsistence needs. While most of the irrigated agriculture is fed by diversion canal systems which tap surface flows, legal and physical water infrastructure in the region is generally poor. A math programming model is used to optimize irrigation strategies under different water-availability and policy scenarios. It is found that the construction of a reservoir could increase net revenues to a representative farming community by up to 30%. However, even greater benefits may result from increasing distribution efficiencies, depending on the initial level of conveyance losses. Further, property rights schemes may be implemented to distribute wealth more evenly through various zones at minimal cost to the agricultural community as a whole. These results may prove useful to policymakers or water authorities in reestablishing water rights.linear programming, irrigation, Afghanistan, Agricultural and Food Policy, Community/Rural/Urban Development, International Development,
An Information Economizing Approach to Capital Budgeting in Firms with Internal Capital Markets
Abstract Capital budgeters in large firm
Effects of Lab Technician Administered vs. Subject Administered Resistance on Wingate Performance
Graduate
Applie
Mobility and strength training with and without protein supplements for pre-frail or frail older adults with low protein intake: the Maximising Mobility and Strength Training (MMoST) feasibility randomised controlled trial protocol
Background Frailty is a common syndrome affecting older people and puts them at risk of hospitalisation, needing care or death. First signs of frailty include reduced muscle strength and mobility decline. A key cause of mobility decline as we age is sarcopenia (age related reduction in muscle strength and mass). Poor nutrition contributes to sarcopenia. A shortfall in protein is associated with reduced muscle mass and strength. This may be due to inadequate intake but also because older people have higher protein needs, especially those with multimorbidity. We need to develop effective treatment to reduce or slow the onset of frailty and mobility decline. Exercise is a recommended treatment. Protein supplements to address the shortfall in protein have the potential to enhance the benefit of regular exercise in frail or pre-frail older adults. This has yet to be definitively demonstrated.
Aim
To establish the feasibility of conducting an RCT evaluating mobility and strength training with or without protein supplements for people over 60 years old who are frail or pre-frail with a low protein intake.
Methods
A multicentre, parallel, 2-group, feasibility RCT. Participants (recruitment target = 50) with problems walking, low protein intake and classified as frail or pre-frail will be recruited from four NHS Physiotherapy community services. Participants will be randomised (secure computer-generated: 1:1) to receive 24 weeks of mobility and strength training (delivered in 16 group sessions plus home exercises) or 24 weeks of mobility and strength training with daily protein supplements. Primary feasibility objectives are to estimate 1) ability to screen and recruit eligible participants, 2) intervention fidelity, adherence, and tolerance and 3) retention of participants at follow up. Secondary objectives are to 1) test data collection procedures, 2) assess data completeness and 3) confirm sample size calculation for a definitive RCT.
Registration
ISRCTN Registry (ISRCTN30405954; 18/10/2022)
Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Polygenic risk; Prediction; Breast cancerRiesgo poligénico; Predicción; Cåncer de mamaRisc poligÚnic; Predicció; Cà ncer de mamaBackground:
The multifactorial risk prediction model BOADICEA enables identification of women at higher or lower risk of developing breast cancer. BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast cancer susceptibility genes and a polygenic component, decomposed into an unmeasured and a measured component - the polygenic risk score (PRS). The current version was developed using a 313 SNP PRS. Here, we evaluated approaches to incorporating this PRS and alternative PRS in BOADICEA.
Methods:
The mean, SD, and proportion of the overall polygenic component explained by the PRS (α2) need to be estimated. α was estimated using logistic regression, where the age-specific log-OR is constrained to be a function of the age-dependent polygenic relative risk in BOADICEA; and using a retrospective likelihood (RL) approach that models, in addition, the unmeasured polygenic component.
Results:
Parameters were computed for 11 PRS, including 6 variations of the 313 SNP PRS used in clinical trials and implementation studies. The logistic regression approach underestimates αâ , as compared with the RL estimates. The RL α estimates were very close to those obtained by assuming proportionality to the OR per 1 SD, with the constant of proportionality estimated using the 313 SNP PRS. Small variations in the SNPs included in the PRS can lead to large differences in the mean.
Conclusions:
BOADICEA can be readily adapted to different PRS in a manner that maintains consistency of the model.This work has been supported by grants from Cancer Research UK (PPRPGM-Nov20\100002); the European Union's Horizon 2020 Research and Innovation Programme under grant agreement numbers 633784 (B-CAST) and 634935 (BRIDGES); the PERSPECTIVE I&I project which is funded by the Government of Canada through Genome Canada (#13529) and the Canadian Institutes of Health Research (#155865), the MinistĂšre de lâĂconomie et de l'Innovation du QuĂ©bec through Genome QuĂ©bec, the Quebec Breast Cancer Foundation, the CHU de Quebec Foundation and the Ontario Research Fund; and by the NIHR Cambridge Biomedical Research Centre (BRC-1215â20014). BCAC is funded by the European Union's Horizon 2020 Research and Innovation Programme (grant numbers 634935 and 633784 for BRIDGES and B-CAST respectively), and the PERSPECTIVE I&I project. Additional funding for BCAC is provided via the Confluence project which is funded with intramural funds from the NCI Intramural Research Program, NIH. Genotyping of the OncoArray was funded by the NIH Grant U19 CA148065, and Cancer Research UK Grant C1287/A16563 and the PERSPECTIVE project supported by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research (grant GPH-129344) and, the MinistĂšre de lâĂconomie, Science et Innovation du QuĂ©bec through Genome QuĂ©bec and the PSRSIIRI-701 grant, and the Quebec Breast Cancer Foundation. MT was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215â20014) and Cancer Research UK C22770/A31523 (International Alliance for Cancer Early Detection programme). The PRISMA study has been funded by Instituto de Salud Carlos III through the project " PI19/01195âł (Co-funded by European Regional Development Fund "A way to make Europe") and it received the institutional support of CERCA Program (Generalitat de Catalunya). The publication costs of this article were defrayed in part by the payment of publication fees. Therefore, and solely to indicate this fact, this article is hereby marked âadvertisementâ in accordance with 18 USC section 1734
"The dirty hand in the latex glove": a study of hand hygiene compliance when gloves are worn.
Wearing of gloves reduces transmission of organisms by healthcare workers' hands but is not a substitute for hand hygiene. Results of previous studies have varied as to whether hand hygiene is worse when gloves are worn. Most studies have been small and used nonstandardized assessments of glove use and hand hygiene. We sought to observe whether gloves were worn when appropriate and whether hand hygiene compliance differed when gloves were worn
Glossopharyngeal Neuralgia: Epidemiology, Risk factors, Pathophysiology, Differential diagnosis, and Treatment Options
Purpose of ReviewThis is a comprehensive review of the most recent literature on glossopharyngeal neuralgia (GPN), a relatively rare form of neuropathic facial pain. It covers the epidemiology, risk factors, pathophysiology, and differential diagnosis given that glossopharyngeal neuralgia can often be confused with other facial pain syndromes. Finally, we extensively review recent findings regarding medical or conservative measures, minimally invasive, and surgical options for potentially treating and managing glossopharyngeal neuralgia.
Recent FindingsAn in-depth analysis of the recent literature indicates that glossopharyngeal neuralgia is not only rare but its etiology and pathophysiology are complex and are often secondary to other disease processes. Regardless, current management options are shown to be effective in controlling pain. Conservatively, first-line management of GPN is carbamazepine, but gabapentin and eslicarbazepine acetate are suitable alternatives. In terms of current minimally invasive pain management techniques, pulsed radiofrequency ablation, nerve blocks, or percutaneous radiofrequency thermocoagulation are effective. Finally, surgical management involves microvascular decompression and rhizotomy.
SummaryWhile there are currently many viable options for addressing glossopharyngeal neuralgia pain ranging from conservative to surgical management, the complex nature of GPN etiology, pathophysiology, and involved anatomical structures prompts further research for more effective ways to treat the disease
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