Colon adenocarcinoma diagnosis in human samples by multicontrast nonlinear optical microscopy of hematoxylin and eosin stained histological sections

Combined multimodal nonlinear optical (NLO) microscopies were used to detect and quantify morphological changes associated with stroma and epithelial transformation in colon cancer. Our findings provide complementary information about tissue microstructure, displaying distinctive patterns between normal and malignant human colon. Additionally, we have demonstrated the usefulness of using fixed tissues for the disease diagnostic and prognostic. The present work provides a framework for using NLO techniques as a clinical diagnostic tool for human colon cancer. NLO metrics could be applied to other disorders, which are characterized by abnormal cell proliferation and collagen assembly.Fil: Adur, Javier Fernando. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina. National Institute of Science and Technology on Photonics Applied to Cell Biology; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Entre Ríos. Universidad Nacional de Entre Ríos. Centro de Investigaciones y Transferencia de Entre Ríos; ArgentinaFil: Bianchi, Mariana. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pelegati, Vitor B.. National Institute of Science and Technology on Photonics Applied to Cell Biology; BrasilFil: Viale, Silvia. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Izaguirre, María Fernanda. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Carvalho, Hernandes Faustino. Universidade Estadual de Campinas; BrasilFil: Cesar, Carlos L.. Universidade Estadual de Campinas; BrasilFil: Casco, Victor Hugo. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentin

Um método proativo para gerenciamento da segurança em instalações nucleares

Em razão da abordagem moderna para tratar a segurança em instalações nucleares que destaca que estas organizações devem ser capazes de avaliar e gerenciar de forma proativa suas atividades torna-se cada vez mais importante a necessidade de instrumentos de avaliação das condições de trabalho. Nesse contexto, este trabalho apresenta um método proativo de gerenciamento da segurança organizacional, o qual apresenta três características inovadoras: 1) a utilização de indicadores preditivos que fornecem informações atuais sobre o desempenho das atividades, permitindo ações preventivas e não somente reativas na gestão da segurança, diferente dos indicadores de segurança tradicionalmente utilizados (indicadores reativos) que são obtidos após a ocorrência de eventos indesejados; 2) a adoção do enfoque da engenharia de resiliência no desenvolvimento dos indicadores – os indicadores são baseados em seis princípios da engenharia de resiliência: comprometimento da alta direção, aprendizagem, flexibilidade, consciência, cultura de justiça e preparação para os problemas; 3) a adoção dos conceitos e propriedades da teoria dos conjuntos fuzzy para lidar com a subjetividade e a consistência dos julgamentos humanos na avaliação dos indicadores. A teoria fuzzy é usada essencialmente para mapear modelos qualitativos de tomada de decisão, e para métodos de representação imprecisa. Os resultados deste trabalho objetivam uma melhoria no desempenho e na segurança nas organizações. O método foi aplicado no setor de expedição de radiofármacos de uma instalação nuclear. Os resultados mostraram que o método é uma boa ferramenta de monitoramento de forma objetiva e proativa das condições de trabalho de um domínio organizacional

A soil classification for seismic hazard assessment and mitigation of the Algarve

The Algarve province of Portugal is located near the E-W Eurasia-Africa plate boundary. It is characterized by a moderate seismicity, with some important historical earthquakes causing important damage and economical losses. Not only has it suffered the effects of large plate boundary events but also the impact of local onshore moderate-sized earthquake sources. The seismic hazard evaluation and mitigation of the area is therefore of great importance to the local populations and the large number of tourists that frequent the region. This paper focuses the evaluation of the most interesting and useful geotechnical near-surface parameters and a soil classification. The classification based upon the European Code 8 for civil engineering and SPT bedrock data, was carried out for land use planning and design of critical facilities. P-wave and S-wave seismic velocities were obtained through the acquisition, processing and interpretation refraction profiles. Hundreds of SPT parameters from available boreholes drilled for engineering and water supply were used and subsoil classification based on geophysical and geotechnical parameters is presented. Other parameters, such as Vp/Vs ratios and the Poisson coefficient were estimated and were computed to provide information for future site effect studies. The experimental procedure tested here is relatively fast, economical and easy to perform and can be useful to estimate soil microzoning and seismic hazard mapping in the absence of local earthquake records

Applying human factors to the design of control centre and workstation of a nuclear reactor

Human factors is a body of scientific factors about human characteristics, covering biomedical, psychological and psychosocial considerations, including principles and applications in the personnel selection areas, training, job performance aid tools and human performance evaluation. Control Centre is a combination of control rooms, control suites and local control stations which are functionally related and all on the same site. Digital control room includes an arrangement of systems, equipment such as computers and communication terminals and workstations at which control and monitoring functions are conducted by operators. Inadequate integration between control room and operators reduces safety, increases the operation complexity, complicates operator training and increases the likelihood of human errors occurrence. The objective of this paper is to present a specific approach for the conceptual and basic design of the control centre and workstation of a nuclear reactor used to produce radioisotope. The approach is based on human factors standards, guidelines and the participation of a multidisciplinary team in the conceptual and basic phases of the design. Using the information gathered from standards and from the multidisciplinary team, an initial sketch 3D of the control centre and workstation are being developed

Repro Money: An Extension Program to Improve Dairy Farm Reproductive Performance

A farmer-directed, team-based Extension program (Repro Money) was developed and executed by the University of Wisconsin–Madison Department of Dairy Science in collaboration with University of Wisconsin–Extension. The goal of the Repro Money program was to help Wisconsin dairy farmers increase reproductive performance and profitability through identification of areas for improvement and implementation of action plans. For the 40 Wisconsin dairy farms that completed the Repro Money program, mean 21-day pregnancy rate increased by 2 percentage points, which was estimated to result in an economic net gain of $31 per cow per year. Extension professionals can apply similar team-based programs to tackle multifaceted, interrelated problems that may be only partially addressed by other, more traditional programming