Optimización a la seguridad al sistema operativo gnu linux mediante nethserver

Este artículo relaciona el proceso de la instalación, configuración y puesta en marcha de la distribución Nethserver en su versión 7.8-x84_64, mostrando un desarrollo paso a paso de su instalación y configuración, seguido del despliegue de servicios como: servidor DHCP, servidor DNS y controlador de dominio, GNU. Desarrollo Linux y configuración detallada del control de acceso. El control del funcionamiento del firewall aplicando las restricciones requeridas se realiza mediante una estación de trabajo GNU/Linux, dando solución a la problemática de migración de sus sistemas operativos, servicios y seguridad de la infraestructura de red.This article relates the process of installation, configuration and commissioning of the Nethserver distribution in version 7.8-x84_64, showing a step-by-step development of its installation and configuration, followed by the deployment of services such as: DHCP server, DNS server and domain controller, GNU. Linux development and detailed configuration of access control. The control of the operation of the firewall by applying the required restrictions is carried out through a GNU/Linux workstation, providing solutions to the problems of migrating its operating systems, services and network infrastructure security

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele