6,461 research outputs found
Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels.
Voltage-gated Na+ channels exhibit two forms of inactivation, one form (fast inactivation) takes effect on the order of milliseconds and the other (slow inactivation) on the order of seconds to minutes. While previous studies have suggested that fast and slow inactivation are structurally independent gating processes, little is known about the relationship between the two. In this study, we probed this relationship by examining the effects of slow inactivation on a conformational marker for fast inactivation, the accessibility of a site on the Na+ channel III-IV linker that is believed to form a part of the fast inactivation particle. When cysteine was substituted for phenylalanine at position 1304 in the rat skeletal muscle sodium channel (microl), application of [2-(trimethylammonium)ethyl]methanethiosulfonate (MTS-ET) to the cytoplasmic face of inside-out patches from Xenopus oocytes injected with F1304C RNA dramatically disrupted fast inactivation and displayed voltage-dependent reaction kinetics that closely paralleled the steady state availability (hinfinity) curve. Based on this observation, the accessibility of cys1304 was used as a conformational marker to probe the position of the fast inactivation gate during the development of and the recovery from slow inactivation. We found that burial of cys1304 is not altered by the onset of slow inactivation, and that recovery of accessibility of cys1304 is not slowed after long (2-10 s) depolarizations. These results suggest that (a) fast and slow inactivation are structurally distinct processes that are not tightly coupled, (b) fast and slow inactivation are not mutually exclusive processes (i.e., sodium channels may be fast- and slow-inactivated simultaneously), and (c) after long depolarizations, recovery from fast inactivation precedes recovery from slow inactivation
Forest diagrams for elements of Thompson's group F
We introduce forest diagrams to represent elements of Thompson's group F.
These diagrams relate to a certain action of F on the real line in the same way
that tree diagrams relate to the standard action of F on the unit interval.
Using forest diagrams, we give a conceptually simple length formula for
elements of F with respect to the {x_0,x_1} generating set, and we discuss the
construction of minimum-length words for positive elements. Finally, we use
forest diagrams and the length formula to examine the structure of the Cayley
graph of F.Comment: 44 pages, 70 figure
Cryptanalysis of group-based key agreement protocols using subgroup distance functions
We introduce a new approach for cryptanalysis of key agreement protocols
based on noncommutative groups. This approach uses functions that estimate the
distance of a group element to a given subgroup. We test it against the
Shpilrain-Ushakov protocol, which is based on Thompson's group F
Radio Sources in the 2dF Galaxy Redshift Survey. I. Radio Source Populations
We present the first results from a study of the radio continuum properties
of galaxies in the 2dF Galaxy Redshift Survey, based on thirty 2dF fields
covering a total area of about 100 square degrees. About 1.5% of galaxies with
b(J) < 19.4 mag are detected as radio continuum sources in the NRAO VLA Sky
Survey (NVSS). Of these, roughly 40% are star-forming galaxies and 60% are
active galaxies (mostly low-power radio galaxies and a few Seyferts). The
combination of 2dFGRS and NVSS will eventually yield a homogeneous set of
around 4000 radio-galaxy spectra, which will be a powerful tool for studying
the distriibution and evolution of both AGN and starburst galaxies out to
redshift z=0.3.Comment: 14 pages, 7 figures, accepted for publication in PAS
Lesions mimicking lacrimal gland pleomorphic adenoma
Aim: To report a series of patients with lacrimal gland lesions simulating the clinicoradiological features of lacrimal gland pleomorphic adenoma (LGPA). Methods: Multicentre retrospective, interventional case series. Clinical records of all patients with lesions mimicking LGPA seen in five orbital units were reviewed. Results: The study included 14 patients (seven men and seven women) with a mean age of 50.9 years. The diagnosis of LGPA was made in all cases by experienced orbital surgeons, based on clinicoradiological features, and lacrimal gland excision was performed. Postoperative histology revealed lymphoma (four patients), chronic dacryoadenitis (three patients), adenoid cystic carcinoma (two patients), Sjogren's syndrome (two patients), cavernous haemangioma (one patient), benign lymphoid hyperplasia (one patient) and granulomatous dacryoadenitis (one patient). Comparison with the total number of histologically confirmed LGPA cases seen during the study period revealed that 22.6% of cases of suspected LGPA were misdiagnosed based on clinicoradiological criteria. Conclusions: Many different lesions may mimic the clinicoradiological features of LGPA. The accepted clinicoradiological criteria used for the diagnosis of LGPA have a high false-positive rate, even in experienced hands. Based on this study, the authors believe that fine-needle aspiration biopsy or intraoperative biopsy and frozen section diagnosis may help reduce unnecessary lacrimal gland excision.Venkatesh C Prabhakaran, Paul S Cannon, Alan McNab, Garry Davis, Brett O’Donnell, Peter J Dolman, Raf Ghabrial, Dinesh Selv
Clues on the evolution of the Carina dwarf spheroidal galaxy from the color distribution of its red giant stars
The thin red giant branch (RGB) of the Carina dwarf spheroidal galaxy appears
at first sight quite puzzling and seemingly in contrast with the presence of
several distinct bursts of star formation. In this Letter, we provide a
measurement of the color spread of red giant stars in Carina based on new BVI
wide-field observations, and model the width of the RGB by means of synthetic
color-magnitude diagrams. The measured color spread, Sigma{V-I}=0.021 +/-
0.005, is quite naturally accounted for by the star-formation history of the
galaxy. The thin RGB appears to be essentially related to the limited age range
of its dominant stellar populations, with no need for a metallicity dispersion
at a given age. This result is relatively robust with respect to changes in the
assumed age-metallicity relation, as long as the mean metallicity over the
galaxy lifetime matches the observed value ([Fe/H] = -1.91 +/- 0.12 after
correction for the age effects). This analysis of photometric data also sets
some constraints on the chemical evolution of Carina by indicating that the
chemical abundance of the interstellar medium in Carina remained low throughout
each episode of star formation even though these episodes occurred over many
Gyr.Comment: 4 pages, 3 figures, accepted for publication in the Astrophysical
Journal Letter
An inverse source problem for the heat equation and the enclosure method
An inverse source problem for the heat equation is considered. Extraction
formulae for information about the time and location when and where the unknown
source of the equation firstly appeared are given from a single lateral
boundary measurement. New roles of the plane progressive wave solutions or
their complex versions for the backward heat equation are given.Comment: 23page
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