Assessment of in vitro antitumoral and antimicrobial activities of marine algae harvested from the eastern Mediterranean sea

Antitumoral activities of five algal extracts obtained from the marine algae Scytosiphon lomentaria, Padina pavonica, Cystoseira mediterranea (Phaeophyceae), Hypnea musciformis and Spyridia filamentosa (Rhodophyta) were assessed against the human breast adenocarcinoma cell line MCF–7 and the human prostate carcinoma epithelium like cell lines DU 145, LNCaP, PC3 using the cytotoxic assay, in vitro. The crude extract of S. filamentosa showed strong cytotoxic activity against the DU-145 cell line, and it showed less than 10% cell viability after treatment. Antimicrobial activities of the crude extracts of algae (with the exception of H. musciformis) were also tested by disc diffusion assay against three Gram positive and five Gram negative bacterial strains and against the yeast pathogen Candida albicans. Among the extraxts, S. lomentaria extract (prepared with methanol) inhibited highly Gram negative bacterium Salmonella typhimurium growth while C. albicans growth was only inhibited by C.mediterrranea extract

FRESENIUS ENVIRONMENTAL BULLETIN

In the present study the antioxidant activities exhibited by the crude extracts of six marine algae collected from the Aegean Sea shores of Turkey were examined: Padina pavonica, Cystoseira barbata, and Sargassum acinarium of the Phaeophyceae (brown algae), Caulerpa racemosa var. cylindracea of the Bryopsidophyceae (green algae), and Jania longifurca and Laurencia obtusa belonging to the Rhodophyceae (red algae). Antioxidant activities were assessed by measurement of glutathion peroxidase activity spectrophotometrically and malondialdehyde measurement for lipid peroxidation by HPLC. Among the species examined, the highest antioxidative capacity according to specific glutathion peroxidase activity was measured from the extract of the brown alga Sargassum acinarium (124 U/mg protein) followed by another brown alga Padina pavonica (16.20 U/mg protein). Malondialdehyde contents of extracts as an indicator of lipid peroxidation were compared, and S. acinarium extract had the lowest MDA level (0.229 mu mol/l). Antimicrobial activities of the methanolic extracts of P. pavonica, Cy. barbata, S. acinarium and J. longifurca were also evaluated against eight microorganisms (7 bacteria and a yeast strain). The extracts showed moderate inhibitory activity

Evaluation of risk factors and outcomes of invasive fungal infections in the first six months after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia: A Turkish multicenter study

41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- MAR 22-25, 2015 -- Istanbul, TURKEYWOS: 000351632903148European Soc Blood & Marrow Transplanta

Risks and outcomes of invasive fungal infections in the first six months after allogeneic hematopoietic stem cell transplantation in pediatric patients: a Multicenter Cohort Study by the Turkish Pediatric Bone Marrow Transplantation Study Group (TPBMT-SG)

41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation -- MAR 22-25, 2015 -- Istanbul, TURKEYWOS: 000351632902206European Soc Blood & Marrow Transplanta