Two new flavans from the trunk and leaves of <i>Horsfieldia glabra</i>

<p>Two new flavans, (2<i>R</i>, 4<i>R</i>)-4′-hydroxy-3′,5′-methyl-6,7-methylenedioxy-4-<i>O</i>-2′-cycloflavan (<b>1</b>), and (2<i>R</i>, 4<i>R</i>)-4′-hydroxy-3′-methyl-6,7-methylenedioxy-4-<i>O</i>-2′-cycloflavan (<b>2</b>), along with six known compounds were isolated from the trunk and leaves of <i>Horsfieldia glabra</i>. Their structures were elucidated by means of extensive spectroscopic analysis. Compounds <b>1</b> and <b>2</b>, together with <b>4</b>–<b>7</b> were assessed for their cytotoxicity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that they had no activity.</p

A new sesquiterpenoid from <i>Polyalthia petelotii</i>

<p>A new sesquiterpenoid (‒)-ethyl dihydrophaseate (<b>1</b>) was isolated from the stems and leaves of <i>Polyalthia petelotii</i>, together with two clerodane diterpenoids, 16<i>α</i>-hydroxycleroda-3,13(14)<i>Z</i>-dien-15,16-olide (<b>2</b>), 15-hydroxy-<i>cis</i>-<i>ent</i>-cleroda-3,13(<i>E</i>)-diene (<b>3</b>), a eudesmane sesquiterpenoid, eudesm-4(15)-ene-7<i>α</i>,11-diol (<b>4</b>), an aromatic aldehyde, vanillin (<b>5</b>), a bisisoquinolines alkaloid, spinosine (<b>6</b>) and an aporphine alkaloid, (‒)-oliveroline-<i>β</i>-<i>N</i>-oxide (<b>7</b>). Their structures were established by extensive spectroscopic analysis, including 2D-NMR techniques. Compounds <b>3</b>, <b>4</b> and <b>6</b> were isolated from the genus <i>Polyalthia</i> for the first time and the others obtained originally from <i>P. petelotii</i>. The isolates were assessed for their cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that only <b>2</b> displayed weak inhibitory activity.</p

A New 5(6→7)abeo-sterol from the twigs of <i>Podocarpus fleuryi</i>

<p>A new 5(6→7)abeo-sterol with rarely reported [6–5-6–5]-fused rings, 3<i>β</i>,5<i>β</i>,6-trihydroxyl-<i>B</i>-norsitostane (<b>1</b>), along with 10 known compounds were isolated from the twigs of <i>Podocarpus fleuryi</i>. Their structures were elucidated by means of extensive spectroscopic analysis. Compound <b>1</b> was assessed for their cytotoxicity against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that it had no activity.</p