<p>Two new flavans, (2<i>R</i>, 4<i>R</i>)-4′-hydroxy-3′,5′-methyl-6,7-methylenedioxy-4-<i>O</i>-2′-cycloflavan (<b>1</b>), and (2<i>R</i>, 4<i>R</i>)-4′-hydroxy-3′-methyl-6,7-methylenedioxy-4-<i>O</i>-2′-cycloflavan (<b>2</b>), along with six known compounds were isolated from the trunk and leaves of <i>Horsfieldia glabra</i>. Their structures were elucidated by means of extensive spectroscopic analysis. Compounds <b>1</b> and <b>2</b>, together with <b>4</b>–<b>7</b> were assessed for their cytotoxicity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that they had no activity.</p
