9 research outputs found
The Role of AI in Drug Discovery: Challenges, Opportunities, and Strategies
Artificial intelligence (AI) has the potential to revolutionize the drug
discovery process, offering improved efficiency, accuracy, and speed. However,
the successful application of AI is dependent on the availability of
high-quality data, the addressing of ethical concerns, and the recognition of
the limitations of AI-based approaches. In this article, the benefits,
challenges and drawbacks of AI in this field are reviewed, and possible
strategies and approaches for overcoming the present obstacles are proposed.
The use of data augmentation, explainable AI, and the integration of AI with
traditional experimental methods, as well as the potential advantages of AI in
pharmaceutical research are also discussed. Overall, this review highlights the
potential of AI in drug discovery and provides insights into the challenges and
opportunities for realizing its potential in this field.
Note from the human-authors: This article was created to test the ability of
ChatGPT, a chatbot based on the GPT-3.5 language model, to assist human authors
in writing review articles. The text generated by the AI following our
instructions (see Supporting Information) was used as a starting point, and its
ability to automatically generate content was evaluated. After conducting a
thorough review, human authors practically rewrote the manuscript, striving to
maintain a balance between the original proposal and scientific criteria. The
advantages and limitations of using AI for this purpose are discussed in the
last section.Comment: 11 pages, 1 figur
The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases
The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article
Flow and wakes in complex terrain and offshore:Model development and verification in UpWind
The paper presents research conducted in the Flow workpackage of the EU funded UPWIND project which focuses on improving models for flow within and downwind of large wind farms in complex terrain and offshore. The main activity is modelling the behaviour of wind turbine wakes in order to improve power output predictions
Wind power forecasting - a review of the state of the art
International audienceThis chapter gives an overview over past and present attempts to predict wind power for single turbines, wind, farms or for whole regions, for a few minutes up to a few days ahead. It is based on a survey and report (Giebel et al., 2011) initiated in the frame of the European project ANEMOS, which brought together many groups from Europe involved in the field with long experience in short-term forecasting. It was then continued in the frame of the follow-up European projects SafeWind and ANEMOS.plus, which concentrated respectively on the forecasting of extreme events and the best possible integration of the forecasts in the work flow of end users