13,662 research outputs found
Towards Real-Time Detection and Tracking of Spatio-Temporal Features: Blob-Filaments in Fusion Plasma
A novel algorithm and implementation of real-time identification and tracking
of blob-filaments in fusion reactor data is presented. Similar spatio-temporal
features are important in many other applications, for example, ignition
kernels in combustion and tumor cells in a medical image. This work presents an
approach for extracting these features by dividing the overall task into three
steps: local identification of feature cells, grouping feature cells into
extended feature, and tracking movement of feature through overlapping in
space. Through our extensive work in parallelization, we demonstrate that this
approach can effectively make use of a large number of compute nodes to detect
and track blob-filaments in real time in fusion plasma. On a set of 30GB fusion
simulation data, we observed linear speedup on 1024 processes and completed
blob detection in less than three milliseconds using Edison, a Cray XC30 system
at NERSC.Comment: 14 pages, 40 figure
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Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2.
Although bone morphogenetic protein-2 (BMP2) has demonstrated extraordinary potential in bone formation, its clinical applications require supraphysiological milligram-level doses that increase postoperative inflammation and inappropriate adipogenesis, resulting in well-documented life-threatening cervical swelling and cyst-like bone formation. Recent promising alternative biomolecular strategies are toward promoting pro-osteogenic activity of BMP2 while simultaneously suppressing its adverse effects. Here, we demonstrated that small molecular phenamil synergized osteogenesis and bone formation with BMP2 in a rat critical size mandibular defect model. Moreover, we successfully elicited the BMP2 adverse outcomes (i.e. adipogenesis and inflammation) in the mandibular defect by applying high dose BMP2. Phenamil treatment significantly improves the quality of newly formed bone by inhibiting BMP2 induced fatty cyst-like structure and inflammatory soft-tissue swelling. The observed positive phenamil effects were associated with upregulation of tribbles homolog 3 (Trib3) that suppressed adipogenic differentiation and inflammatory responses by negatively regulating PPARγ and NF-κB transcriptional activities. Thus, use of BMP2 along with phenamil stimulation or Trib3 augmentation may be a promising strategy to improve clinical efficacy and safety of current BMP therapeutics
Controllable Abstractive Dialogue Summarization with Sketch Supervision
In this paper, we aim to improve abstractive dialogue summarization quality and, at the same time, enable granularity control. Our model has two primary components and stages: 1) a two-stage generation strategy that generates a preliminary summary sketch serving as the basis for the final summary. This summary sketch provides a weakly supervised signal in the form of pseudo-labeled interrogative pronoun categories and key phrases extracted using a constituency parser. 2) A simple strategy to control the granularity of the final summary, in that our model can automatically determine or control the number of generated summary sentences for a given dialogue by predicting and highlighting different text spans from the source text. Our model achieves state-of-the-art performance on the largest dialogue summarization corpus SAMSum, with as high as 50.79 in ROUGE-L score. In addition, we conduct a case study and show competitive human evaluation results and controllability to human-annotated summaries
Interactive energy management for networked microgrids with risk aversion
Department of Finance and Education of Guangdong Province 2016[202]: Key Discipline Construction Programme, China; Guangdong Foshan Power Construction Corporation Group Co. Ltd., Foshan, China
Successful strategies for engaging Chinese breast cancer survivors in a randomized controlled trial
This is the author accepted manuscript. The final version is available from the American Psychological Association via the DOI in this record.Chinese immigrant breast cancer survivors face various challenges due to cultural and
socioecological factors. Research efforts to develop culturally sensitive interventions have been
limited by lack of knowledge regarding successful recruitment and implementation practices
among Chinese immigrant populations. This paper documents strategies utilized during the
development and implementation of a randomized controlled trial of a culturally sensitive
psychosocial intervention for Chinese immigrant breast cancer survivors. In partnership with a
community agency, we developed culturally and linguistically appropriate research materials,
recruited participants from community channels, and conducted longitudinal data collection. Key
strategies include building equitable research partnerships with community agencies to engage
participants; being responsive to the needs of community agencies and participants; considering
within-group diversity of the research population; utilizing recruitment as an opportunity for
relationship-building with participants; and developing key strategies to promote retention.
Successful participant engagement in cancer intervention research is the result of collaboration
among breast cancer survivors, community leaders and agencies, and academic researchers. The
engagement process for this study is novel because we have emphasized cultural factors in the
process and taken a relational approach to recruitment and retention
Characterization of the chronobiological signals based on the continuous wavelet transform
Chronobiology, which studies periodic patterns or rhythms of the living beings, often needs to characterize the observed chronobiological time series (CTS) and to study the stability and adaptability of the periodic patterns in different environmental conditions. Fourier transform (FT) based methods and complex demodulation (CD) approach have been widely used in such study. However, the former lacks temporal resolution and the later needs to extract the temporal behaviors of individual frequencies. In this paper, we proposed a new approach to characterize the CTS based on the continuous wavelet transform (CWT). It allows us to investigate the time-frequency dynamics of different rhythmic-band activities in the CTS simultaneously. Two application results have been presented to illustrate the proposed method.published_or_final_versio
Anode modification of polyfluorene-based polymer light-emitting devices
A glycerol-modified poly(3,4-ethylene dioxythiophene) (PEDOT): poly(styrene sulfonate) (PSS) layer was used as an anode buffer layer in polymer light-emitting devices using poly(9,9-dioctylfluorene) (F8) as the emitter. Devices with a configuration of indium tin oxide/PEDOT:PSS (with or without glycerol)/F8/CsF/Al were fabricated. It was found that the glycerol-modified device showed a much larger current density than the unmodified device. At an operating voltage of 6 V, the glycerol-modified device showed a luminance of 1300Cd/m 2 and a current efficiency of 1.7 Cd/A compared to the corresponding values of 500Cd/m 2 and 1.3 Cd/A in the unmodified device. Analysis by ultraviolet spectroscopy suggests that the two devices have the same energy level structure and the performance improvement should not be due to change in the PEDOT/polymer interface. It was further found that incorporating a suitable amount of glycerol into the PEDOT:PSS layer can increase its conductivity by six times. This leads to a better balance in the hole and electron currents and thus improved device efficiency. © 2002 American Institute of Physics.published_or_final_versio
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of mold and yeast cultures of Penicillium marneffei
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