Herodotus, Xerxes en de Babylonische opstanden van 484 v. Chr.

Horizon 2020(H2020)682241Middle Eastern Studie

De wilde jeugd der assyriologie

Oratie uitgesproken door Prof.dr. C. Waerzeggers bij de aanvaarding van het ambt van hoogleraar in de Assyriologie aan de Universiteit Leiden op vrijdag 1 december 2017Middle Eastern Studie

Babylonian entrepreneurs

Horizon 2020(H2020)682241Middle Eastern Studie

Digital prosopography of Babylonia: new horizons

Horizon 2020(H2020)682241Middle Eastern Studie

The day before Cyrus entered Babylon

Horizon 2020(H2020)682241Middle Eastern Studie

An unfinished duplicate of a marriage contract from the reign of Darius I

Horizon 2020(H2020)682241Middle Eastern Studie

Collations of CUSAS 28

Horizon 2020(H2020)682241Middle Eastern Studie

Super-resolution track-density imaging studies of mouse brain: Comparison to histology

The recently proposed track-density imaging (TDI) technique was introduced as a means to achieve superresolution using diffusion MRI. This technique is able to increase the spatial resolution of the reconstructed images beyond the acquired MRI resolution by incorporating information from whole-brain fibre-tracking results. It not only achieves super-resolution, but also provides very high anatomical contrast with a new MRI contrast mechanism. However, the anatomical information-content of this novel contrast mechanism has not yet been assessed. In this work, we perform such a study using diffusion MRI of ex vivo mouse brains acquired at 16.4T, to compare the results of the super-resolution TDI technique with histological staining (myelin and Nissl stains) in the same brains. Furthermore, a modified version of the directionally-encoded colour TDI map using short-tracks is introduced, which reduces the TDI intensity dynamic range, and therefore enhances the directionality colour-contrast. Good agreement was observed between structures visualised in the superresolution TDI maps and in the histological sections, supporting the anatomical information-content of the images generated using the TDI technique. The results therefore show that the TDI methodology does provide meaningful and rich anatomical contrast, in addition to achieving super-resolution. Furthermore, this study is the first to show the application of TDI to mouse brain imaging: the high-resolution, high-quality images demonstrate the useful complementary information that can be achieved using super-resolution TDI

Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease

peer reviewedMolecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it allows the non-invasive determination of the dynamics of changes on the molecular level. IMAGING OF AD CHARACTERISTIC CHANGES BY microPET: The imaging technology being employed includes magnetic resonance imaging (MRI) and nuclear imaging as well as optical-based imaging technologies. These imaging modalities are employed together or alone for disease phenotyping, development of imaging-guided therapeutic strategies and in basic and translational research. In this study, we review recent investigations employing positron emission tomography and MRI for phenotyping mouse models of Alzheimer's disease by imaging. We demonstrate that imaging has an important role in the characterization of mouse models of neurodegenerative diseases