14 research outputs found
Prevalence of colonizing bacteria and their association with primary bacteremias in hemodialysis of a university hospital
to be from 2.5 to 5.5 cases per 1,000 catheter-day. the clinical impact is relevant and increases the cost of the HD Unit. Methods: The present study is the irst of 2 phases. It was conducted from January to December of 2012, and included all patients and nurses who were in the HD Unit. The prevalence of Gramnegative bacilli (GNB) and methicillin-resistant Staphylococcus aureus (MrSA) colonizing the nasal passages and the skin is described. Also, phenotypic association was sought by genus, species and sensitivities between colonizing bacterial strains and blood cultures with GNB and MRSA. Results: the study included 70 patients and 10 nurses. the prevalence of nasal colonization in patients by GNB was 9% and 6% in the pericatheter, and no nursing GNB colonization was discovered. The prevalence of MRSA nasal colonization was 19% and 6% in the pericatheter for patients and in the nurses the nasal colonization was 50% and 10% in the hands. We identiied 29 cases of primary bacteremia. The primary bacteremia rate is 1.5 per 1,000 catheter-day or 0.4 episodes per patient per year. Conclusion: We demonstrated a high prevalence of MrSA colonization in patients and nurses in the HD Unit. No relationship was found between primary bacteremia by GNB and patients and
nurses’ bacteria colonization by the phenotypic comparison
Antimicrobial Activity of a Cationic Guanidine Compound against Two Pathogenic Oral Bacteria
This study evaluated the potential antimicrobial properties of a polyguanidine (CatDex) on two oral bacteria. Chlorhexidine gluconate 1340 μmoL L−1 (CHX 0.12%) was used as control. Streptococcus mutans (S. mutans) and Porphyromonas gingivalis (P. gingivalis) were grown in BHI media. Bacterial sensitivity and antimicrobial activity were determined by the minimum inhibitory concentration (MIC) and Kirby-Bauer methods. To study side effects, that is, toxicity, dental pulp stem cells (DPSCs) were used. Fluorometric cytotoxicity and confocal microscopy assays were used in order to test cell viability. CatDex inhibited growth of S. mutans at all concentrations and growth of P. gingivalis at all concentrations except 25 μmoL L−1. The MIC of CatDex was 50 μmoL L−1 for both S. mutans and P. gingivalis. The inhibition of bacteria exposed for 8 h at 50 μmoL L−1 of CatDex exhibited increased antimicrobial activity over time, with 91% inhibition in both bacteria. The antimicrobial activities of CatDex and CHX were similar when tested on two common bacteria. CatDex was significantly less toxic to DPSCs. CatDex toxicity depended on time and not on concentration. With regard to clinical relevance, CatDex may have potential as a novel antimicrobial agent. Further studies are in progress
Prevalencia e impacto de la violencia íntima de pareja en mujres con lupus eritematoso sistémico
Objective: Stress and trauma are psychosocial factors with an impact on the course
of systemic lupus erythematosus (SLE). The influence of violence on SLE has not
been entirely explored, even though women (including patients with rheumatic
diseases) are a vulnerable population to any form of violence. This study aims to
assess the prevalence and impact of intimate partner violence (IPV) on healthrelated quality of life in women with SLE.
Methods: An observational, cross-sectional, and analytical study was conducted at
a rheumatology clinic of a university hospital from September 2022 and September
2023. We evaluated the presence of IPV in 85 women with SLE with the Hurt,
Insulted, Threatened with Harm and Screamed at (HITS) questionnaire and the
Index of Spouse Abuse (ISA), and quality of life with LupusQoL.
Results: The prevalence by HITS score of past-year IPV was 24.4% and of lifetime
IPV was 36.5%. Past-year non-physical violence was present in 17.1% of patients
by ISA, and 27.1% were victims in their lifetime. While in physical violence, 7.3% were victims in the previous year and 21.2% in their lifetime. The total quality of life
and the emotional domain by LupusQoL were diminished in victims of past-year IPV,
compared to those who weren’t exposed (p = 0.018 and p = 0.036, respectively).
Past-year HITS score correlated with the physician global assessment (PGA) (rho =
0.301, p = 0.006), while lifetime HITS score correlated with PGA (rho = 0.329, p =
0.002) and SLEDAI-2K (rho = 0.277, p = 0.010).
Conclusion: We found that 1 in 4 women suffered IPV in the previous year, and those
who were exposed had diminished quality of life. Also, the severity of the abuse
correlated with disease activity. The findings of this study highlight the relevance of
assessing psychosocial factors in these patients to achieve better comprehensive
care
Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration
Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the
upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4-
related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of the
relationship between EAF and IgG4-RD. Case Report: We report the case of a 37-year-old woman
with nasal deformity and facial pain. The lesion was surgically excised. Histological examination
revealed features of EAF with an IgG4/IgG plasma cell ratio >73% and 31 IgG4 stained cells per
high power field. No clinical or radiological recurrence was detected during follow-up. Serum
IgG4 quantification one year after surgery was within normal limits. Discussion: The relationship
between both entities may have therapeutic impact because IgG4-RD of the head and neck has a
high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this
infrequent disease are necessary to elucidate appropriate treatment and prognosis