The Value Line Enigma Extended - An Examination Of the Performance Of Option Recommendations

We extend the research on the Value Line Enigma by examining the performance of call recommendations in Value Line Options. Galai\u27s hedge decomposition procedure identifies the components of the calls\u27 returns. Abnormal call returns were most pronounced immediately following the purchase, which is consistent with studies of Value Line\u27s stock rankings. The largest and most significant abnormal performance was by calls assigned the highest rank written on stocks judged by Value Line to be correctly priced. Abnormal call return performance by joint call and stock ranks was consistent with the hypothesis that Value Line identifies underpriced call options

Knowledge of and attitudes to sports drinks of adolescents living in South Wales, UK

Background: The UK sports drinks market has a turnover in excess of £200M. Adolescents consume 15.6% of total energy as free sugars, much higher than the recommended 5%. Sugar sweetened beverages, including sports drinks, account for 30% of total free sugar intake for those aged 11-18 years. Objective: To investigate children’s knowledge and attitudes surrounding sports drinks. Method: 183 self-complete questionnaires were distributed to four schools in South Wales. Children aged 12 - 14 were recruited to take part. Questions focussed on knowledge of who sports drinks are aimed at; the role of sports drinks in physical activity and the possible detrimental effects to oral health. Recognition of brand logo and sports ambassadors and the relationship of knowledge to respondent’s consumption of sports drinks were assessed. Results: There was an 87% (160) response rate. 89.4% (143) claimed to drink sports drinks. 45.9% thought that sports drinks were aimed at everyone; approximately a third (50) viewed teenagers as the target group. Over 2/3rds recognised the brand logos, yet less than a 1/3rd could identify brand ambassadors. About half were aware that dental erosion may result from consumption and approximately 2/3rds knew that they were linked to dental caries and energy provision. Despite this the majority claimed to drink them. As previously reported most of those drinking sports drinks did so because of the taste. Conclusion: Whilst most of the respondents had some understanding of the detrimental effects on health the majority of them were drinking them regularly despite this knowledge. Work is therefore needed at a macro level, with soft drink manufacturers, to consider marketing and reformulation of products for adolescent consumers who appear to enjoy them

Evaluating the Written Work of Others: One Way Economics Students Can Learn to Write

The authors present a series of writing assignments that teaches students how to evaluate and critique the written economic work of others. The foundation text is McCloskey’s (2000) Economical Writing. The students’ dialogues with McCloskey, with each other, and with the authors of the pieces they evaluate sharpen their understanding of, and ability to use, language as an instrument of economic thought. Interviews with former students identify specific benefits from the student perspective of this approach. The authors show how the assignment series can be modified in several ways and how the general approach, as well as the foundation text, can be used in different economics courses

Environmental Site Characterization and Risk-Based Evaluation of a Site Contaminated with Tetrachloroethene (PCE) and Trichloroethene (TCE)

A healthcare company purchased property in eastern Iowa for a facility expansion. Before the purchase, a Phase I environmental site assessment (ESA) revealed that the property was the site of a former dry cleaning business. Phase II sampling and testing indicated that tetrachloroethene (PCE) and trichloroethene (TCE) had affected site soil and groundwater. Maximum concentrations of PCE and TCE in groundwater were 538 and 209 µg/L, respectively, and 105 and 1.51 mg/kg in soil. Additional sampling delineated the vertical and horizontal extent of contamination in the soil. The concentrations of the chlorinated solvents in both the soil and groundwater were below levels of regulatory concern. However, the company was concerned that the Iowa statewide standard for PCE in soil (780 mg/kg) might not provide adequate protection for several exposure pathways and wanted to assess the risk to the public from the contamination at the site. The results of a receptor survey were used to develop site-specific target levels (SSTLs) for contamination, using accepted human health exposure factors, models, and chemical-specific toxicity values. The recommended remedial options allowed the company to minimize the human health risks posed by contamination at the site

Relative age in the school year and risk of mental health problems in childhood, adolescence, and young adulthood

Purpose Relative age within the school year (‘relative age’) is associated with increased rates of symptoms and diagnoses of mental health disorders, including ADHD. We aimed to investigate how relative age influences mental health and behaviour before, during and after school (age range: 4–25 years). Method We used a regression discontinuity design to examine the effect of relative age on risk of mental health problems using data from a large UK population-based cohort (Avon Longitudinal Study of Parents and Children (ALSPAC); N = 14,643). We compared risk of mental health problems between ages 4 and 25 years using the parent-rated Strengths and Difficulties Questionnaire (SDQ), and depression using self-rated and parent-rated Short Mood and Feelings Questionnaire (SMFQ) by relative age. Results The youngest children in the school year have greater parent-rated risk of mental health problems, measured using parent-rated SDQ total difficulties scores. We found no evidence of differences before school entry [estimated standardised mean difference (SMD) between those born on 31 August and 1 September: .02 (−.05, .08)]. We found that estimates of effect size for a 1-year difference in relative age were greatest at 11 years [SMD: .22 (.15, .29)], but attenuated to the null at 25 years [SMD: −.02 (−.11, .07)]. We did not find consistent evidence of differences in self-rated and parent-rated depression by relative age. Conclusions Younger relative age is associated with poorer parent-rated general mental health, but not symptoms of depression

Expression of c-myc is not critical for cell proliferation in established human leukemia lines

BACKGROUND: A study was undertaken to resolve preliminary conflicting results on the proliferation of leukemia cells observed with different c-myc antisense oligonucleotides. RESULTS: RNase H-active, chimeric methylphosphonodiester / phosphodiester antisense oligodeoxynucleotides targeting bases 1147–1166 of c-myc mRNA downregulated c-Myc protein and induced apoptosis and cell cycle arrest respectively in cultures of MOLT-4 and KYO1 human leukemia cells. In contrast, an RNase H-inactive, morpholino antisense oligonucleotide analogue 28-mer, simultaneously targeting the exon 2 splice acceptor site and initiation codon, reduced c-Myc protein to barely detectable levels but did not affect cell proliferation in these or other leukemia lines. The RNase H-active oligodeoxynucleotide 20-mers contained the phosphodiester linked motif CGTTG, which as an apoptosis inducing CpG oligodeoxynucleotide 5-mer of sequence type CGNNN (N = A, G, C, or T) had potent activity against MOLT-4 cells. The 5-mer mimicked the antiproliferative effects of the 20-mer in the absence of any antisense activity against c-myc mRNA, while the latter still reduced expression of c-myc in a subline of MOLT-4 cells that had been selected for resistance to CGTTA, but in this case the oligodeoxynucleotide failed to induce apoptosis or cell cycle arrest. CONCLUSIONS: We conclude that the biological activity of the chimeric c-myc antisense 20-mers resulted from a non-antisense mechanism related to the CGTTG motif contained within the sequence, and not through downregulation of c-myc. Although the oncogene may have been implicated in the etiology of the original leukemias, expression of c-myc is apparently no longer required to sustain continuous cell proliferation in these culture lines

Identification of a Lotus viral pathogen

A virus collection was used to identify a pathogen suitable for laboratory use with the model legume Lotus japonicus. Several Lotus species or L. japonicus accessions were tested and various degrees of susceptibility to the Arabis mosaic virus derived from barley (ArMV-ba) were found. Virus multiplication and persistence in Lotus tissue were examined, as well as plant responses to it. Sensitivity to the virus among the accessions and species is discussed in light of their geographical origi