913 research outputs found

    The Optical Polarization and Warm Absorber in IRAS 17020+4544

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    We report the detection of ionized absorption in the ASCA spectrum of the narrow-line Seyfert 1 galaxy IRAS 17020+4544. Subsequent optical spectropolarimetry revealed high polarization increasing from 3% in the red to 5% in the blue, indicating electron or dust scattering as a likely origin. The broad emission line HĪ±\alpha is somewhat less polarized than the continuum, supporting a location of the polarizing material within the AGN. The Balmer line decrement and reddened optical spectrum support the presence of a dusty warm absorber in this object. We compared the broad band optical polarization and ionized X-ray absorption of a collection of Seyfert 1 and 1.5 galaxies, excluding classes of objects that are likely to have significant neutral X-ray absorption. Warm absorber objects are generally more likely to have high optical polarization than objects with no detected ionized absorption. This result lends additional support to the idea that the warm absorber is associated with dust and implies either that dust transmission is responsible for at least part of the polarization or that the polarization is revealed because of the dimming of the optical spectrum. Spectropolarimetry of Seyfert 1s generally locates the scattering material inside the narrow-line region and often close to or within the broad line region, consistent with estimates of the location of the dusty warm absorber.Comment: 11 pages using (AASTeX) aaspp4.sty and 3 Postscript figures. Accepted for publication in Astrophysical Journal Letter

    Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.

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    Transnationalism and Social Work Education

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    Transnational movements, networks, and relationships are everywhere in this ā€œworld on the moveā€ (Williams & Graham, 2014, p. i1). Transnational peoples maintain relationships of interdependence and support with families and communities in their places of origin, often returning regularly, while starting new lives and making new connections. Transnationalism is characterized by mobilities and networks, by social integration, and by extended and extensive relationship ties of family, neighborhood, religious faith, or combinations thereof (Valtonen, 2008). While disciplines across the world including sociology, human geography, and cultural anthropology engage with the implications of transnationalism (Baubƶck & Faist, 2010), social work in England and mainland Europe has not achieved similar levels of engagement. As Cox and Geisen state: ā€œthe social world is being transformed by migration and social work is playing catch-upā€ (2014, p. i162)

    Is it Round? Spectropolarimetry of the Type II-P Supernova 1999em

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    We present the first multi-epoch spectropolarimetry of a type II plateau supernova (SN II-P), with optical observations of SN 1999em on days 7, 40, 49, 159, and 163 after discovery. These data are used to probe the geometry of the electron-scattering atmosphere before, during, and after the plateau phase, which ended roughly 90 days after discovery. Weak continuum polarization with an unchanging polarization angle (theta ~ 160 deg) is detected at all epochs, with p ~ 0.2% on day 7, p ~ 0.3% on days 40 and 49, and p ~ 0.5% in the final observations. Distinct polarization modulations across strong line features are present on days 40, 49, 159, and 163. Uncorrected for interstellar polarization (which is believed to be quite small), polarization peaks are associated with strong P Cygni absorption troughs and nearly complete depolarization is seen across the H-alpha emission profile. The temporal evolution of the continuum polarization and sharp changes across lines indicate polarization intrinsic to SN 1999em. When modeled in terms of the oblate, electron-scattering atmospheres of Hoeflich, the observed polarization implies anasphericity of at least 7% during the period studied. The temporal polarization increase may indicate greater asphericity deeper into the ejecta. We discuss the implications of asphericity on the use of type II-P supernovae as primary extragalactic distance indicators through the expanding photosphere method (EPM). If asphericity produces directionally dependant flux and peculiar galaxy motions are characterized by sigma_v_rec = 300 km/s, it is shown that the agreement between previous EPM measurements of SNe II and distances to the host galaxies predicted by a linear Hubble law restrict mean SN II asphericity to values less than 30% (3-sigma) during the photospheric phase.Comment: 65 pages (29 Figures, 4 Tables), Accepted for publication in the June 1, 2001 edition of ApJ. Revised statistical analysis of scatter in Hubble diagram of previous EPM distances and the implications for mean SN II asphericit

    Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

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    BackgroundIn fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but increase at metamorphosis; the larger number and higher levels of editing suggest editing is most required when the brain is most complex. This idea is consistent with the fact that Adar mutations affect the adult brain most dramatically. However, it is unknown whether Drosophila Adar RNA editing events mediate some coherent physiological effect. To address this question, we performed a genetic screen for suppressors of Adar mutant defects. Adar5G1 null mutant flies are partially viable, severely locomotion defective, aberrantly accumulate axonal neurotransmitter pre-synaptic vesicles and associated proteins, and develop an age-dependent vacuolar brain neurodegeneration.ResultsA genetic screen revealed suppression of all Adar5G1 mutant phenotypes tested by reduced dosage of the Tor gene, which encodes a pro-growth kinase that increases translation and reduces autophagy in well-fed conditions. Suppression of Adar5G1 phenotypes by reduced Tor is due to increased autophagy; overexpression of Atg5, which increases canonical autophagy initiation, reduces aberrant accumulation of synaptic vesicle proteins and suppresses all Adar mutant phenotypes tested. Endosomal microautophagy (eMI) is another Tor-inhibited autophagy pathway involved in synaptic homeostasis in Drosophila. Increased expression of the key eMI protein Hsc70-4 also reduces aberrant accumulation of synaptic vesicle proteins and suppresses all Adar5G1 mutant phenotypes tested.ConclusionsThese findings link Drosophila Adar mutant synaptic and neurotransmission defects to more general cellular defects in autophagy; presumably, edited isoforms of CNS proteins are required for optimum synaptic response capabilities in the brain during the behaviorally complex adult life stage

    Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects

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    Flies with mutations in the single Drosophila Adar gene encoding an RNA editing enzyme involved in editing 4% of all transcripts have severe locomotion defects and develop age-dependent neurodegeneration. Vertebrates have two ADAR-editing enzymes that are catalytically active; ADAR1 and ADAR2. We show that human ADAR2 rescues Drosophila Adar mutant phenotypes. Neither the short nuclear ADAR1p110 isoform nor the longer interferon-inducible cytoplasmic ADAR1p150 isoform rescue walking defects efficiently, nor do they correctly edit specific sites in Drosophila transcripts. Surprisingly, human ADAR1p110 does suppress age-dependent neurodegeneration in Drosophila Adar mutants whereas ADAR1p150 does not. The single Drosophila Adar gene was previously assumed to represent an evolutionary ancestor of the multiple vertebrate ADARs. The strong functional similarity of human ADAR2 and Drosophila Adar suggests rather that these are true orthologs. By a combination of direct cloning and searching new invertebrate genome sequences we show that distinct ADAR1 and ADAR2 genes were present very early in the Metazoan lineage, both occurring before the split between the Bilateria and Cnidarians. The ADAR1 gene has been lost several times, including during the evolution of insects and crustacea. These data complement our rescue results, supporting the idea that ADAR1 and ADAR2 have evolved highly conserved, distinct functions
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